Intertumoral Heterogeneity within Medulloblastoma Subgroups
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CAVALLI, F.M.G.; M. REMKE; L. RAMPASEK; J. PEACOCK; D.J.H. SHIH; B. LUU; L. GARZIA; J. TORCHIA; C. NOR; A.S. MORRISSY; S. AGNIHOTRI; Y.Y. THOMPSON; C.M. KUZAN-FISCHER; H. FAROOQ; K. ISAEV; C. DANIELS; B.K. CHO; S.K. KIM; K.C. WANG; J.Y. LEE; W.A. GRAJKOWSKA; M. PEREK-POLNIK; A. VASILJEVIC; C. FAURE-CONTER; A. JOUVET; C. GIANNINI; A.A.N. RAO; K.K.W. LI; H.K. NG; C.G. EBERHART; I.F. POLLACK; R.L. HAMILTON; G.Y. GILLESPIE; J.M. OLSON; S. LEARY; W.A. WEISS; B. LACH; L.B. CHAMBLESS; R.C. THOMPSON; M.K. COOPER; R. VIBHAKAR; P. HAUSER; M.L.C. van VEELEN; J.M. KROS; P.J. FRENCH; Y.S. RA; T. KUMABE; E. LOPEZ-AGUILAR; Karel ZITTERBART; Jaroslav ŠTĚRBA; G. FINOCCHIARO; M. MASSIMINO; E.G. VAN MEIR; S. OSUKA; T. SHOFUDA; A. KLEKNER; M. ZOLLO; J.R. LEONARD; J.B. RUBIN; N. JABADO; S. ALBRECHT; J. MORA; T.E. VAN METER; S. JUNG; A.S. MOORE; A.R. HALLAHAN; J.A. CHAN; D.C. TIRAPELI; C.G. CARLOTTO; M. FOULADI; J. PIMENTEL; C.C. FARIA; A.G. SAAD; L. MASSIMI; L.M. LIAU; H. WHEELER; H. NAKAMURA; S.K. ELBABAA; M. PEREZPENA DIAZCONTI; F.C. PONCE DE LEÓN; S. ROBINSON; M. ZAPOTOCKY; A. LASSALETTA; A. HUANG; C.E. HAWKINS; U. TABORI; E. BOUFFET; U. BARTELS; P.B. DIRKS; J.T. RUTKA; G.D. BADER; J. REIMAND; A. GOLDENBERG; V. RAMASWAMY a M.D. TAYLOR
Vydání
Cancer Cell, Cambridge, Cell Press, 2017, 1535-6108
While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.
CAVALLI, F.M.G.; M. REMKE; L. RAMPASEK; J. PEACOCK; D.J.H. SHIH; B. LUU; L. GARZIA; J. TORCHIA; C. NOR; A.S. MORRISSY; S. AGNIHOTRI; Y.Y. THOMPSON; C.M. KUZAN-FISCHER; H. FAROOQ; K. ISAEV; C. DANIELS; B.K. CHO; S.K. KIM; K.C. WANG; J.Y. LEE; W.A. GRAJKOWSKA; M. PEREK-POLNIK; A. VASILJEVIC; C. FAURE-CONTER; A. JOUVET; C. GIANNINI; A.A.N. RAO; K.K.W. LI; H.K. NG; C.G. EBERHART; I.F. POLLACK; R.L. HAMILTON; G.Y. GILLESPIE; J.M. OLSON; S. LEARY; W.A. WEISS; B. LACH; L.B. CHAMBLESS; R.C. THOMPSON; M.K. COOPER; R. VIBHAKAR; P. HAUSER; M.L.C. van VEELEN; J.M. KROS; P.J. FRENCH; Y.S. RA; T. KUMABE; E. LOPEZ-AGUILAR; Karel ZITTERBART; Jaroslav ŠTĚRBA; G. FINOCCHIARO; M. MASSIMINO; E.G. VAN MEIR; S. OSUKA; T. SHOFUDA; A. KLEKNER; M. ZOLLO; J.R. LEONARD; J.B. RUBIN; N. JABADO; S. ALBRECHT; J. MORA; T.E. VAN METER; S. JUNG; A.S. MOORE; A.R. HALLAHAN; J.A. CHAN; D.C. TIRAPELI; C.G. CARLOTTO; M. FOULADI; J. PIMENTEL; C.C. FARIA; A.G. SAAD; L. MASSIMI; L.M. LIAU; H. WHEELER; H. NAKAMURA; S.K. ELBABAA; M. PEREZPENA DIAZCONTI; F.C. PONCE DE LEÓN; S. ROBINSON; M. ZAPOTOCKY; A. LASSALETTA; A. HUANG; C.E. HAWKINS; U. TABORI; E. BOUFFET; U. BARTELS; P.B. DIRKS; J.T. RUTKA; G.D. BADER; J. REIMAND; A. GOLDENBERG; V. RAMASWAMY a M.D. TAYLOR. Intertumoral Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. Cambridge: Cell Press, 2017, roč. 31, č. 6, s. "737"-"+", 24 s. ISSN 1535-6108. Dostupné z: https://doi.org/10.1016/j.ccell.2017.05.005.
@article{1399418, author = {Cavalli, F.M.G. and Remke, M. and Rampasek, L. and Peacock, J. and Shih, D.J.H. and Luu, B. and Garzia, L. and Torchia, J. and Nor, C. and Morrissy, A.S. and Agnihotri, S. and Thompson, Y.Y. and KuzanandFischer, C.M. and Farooq, H. and Isaev, K. and Daniels, C. and Cho, B.K. and Kim, S.K. and Wang, K.C. and Lee, J.Y. and Grajkowska, W.A. and PerekandPolnik, M. and Vasiljevic, A. and FaureandConter, C. and Jouvet, A. and Giannini, C. and Rao, A.A.N. and Li, K.K.W. and Ng, H.K. and Eberhart, C.G. and Pollack, I.F. and Hamilton, R.L. and Gillespie, G.Y. and Olson, J.M. and Leary, S. and Weiss, W.A. and Lach, B. and Chambless, L.B. and Thompson, R.C. and Cooper, M.K. and Vibhakar, R. and Hauser, P. and Veelen, M.L.C. van and Kros, J.M. and French, P.J. and Ra, Y.S. and Kumabe, T. and LopezandAguilar, E. and Zitterbart, Karel and Štěrba, Jaroslav and Finocchiaro, G. and Massimino, M. and Van Meir, E.G. and Osuka, S. and Shofuda, T. and Klekner, A. and Zollo, M. and Leonard, J.R. and Rubin, J.B. and Jabado, N. and Albrecht, S. and Mora, J. and Van Meter, T.E. and Jung, S. and Moore, A.S. and Hallahan, A.R. and Chan, J.A. and Tirapeli, D.C. and Carlotto, C.G. and Fouladi, M. and Pimentel, J. and Faria, C.C. and Saad, A.G. and Massimi, L. and Liau, L.M. and Wheeler, H. and Nakamura, H. and Elbabaa, S.K. and Perezpena Diazconti, M. and Ponce de León, F.C. and Robinson, S. and Zapotocky, M. and Lassaletta, A. and Huang, A. and Hawkins, C.E. and Tabori, U. and Bouffet, E. and Bartels, U. and Dirks, P.B. and Rutka, J.T. and Bader, G.D. and Reimand, J. and Goldenberg, A. and Ramaswamy, V. and Taylor, M.D.}, article_location = {Cambridge}, article_number = {6}, doi = {https://doi.org/10.1016/j.ccell.2017.05.005}, keywords = {Intertumoral Heterogeneity}, language = {eng}, issn = {1535-6108}, journal = {Cancer Cell}, title = {Intertumoral Heterogeneity within Medulloblastoma Subgroups}, volume = {31}, year = {2017} }
TY - JOUR ID - 1399418 AU - Cavalli, F.M.G. - Remke, M. - Rampasek, L. - Peacock, J. - Shih, D.J.H. - Luu, B. - Garzia, L. - Torchia, J. - Nor, C. - Morrissy, A.S. - Agnihotri, S. - Thompson, Y.Y. - Kuzan-Fischer, C.M. - Farooq, H. - Isaev, K. - Daniels, C. - Cho, B.K. - Kim, S.K. - Wang, K.C. - Lee, J.Y. - Grajkowska, W.A. - Perek-Polnik, M. - Vasiljevic, A. - Faure-Conter, C. - Jouvet, A. - Giannini, C. - Rao, A.A.N. - Li, K.K.W. - Ng, H.K. - Eberhart, C.G. - Pollack, I.F. - Hamilton, R.L. - Gillespie, G.Y. - Olson, J.M. - Leary, S. - Weiss, W.A. - Lach, B. - Chambless, L.B. - Thompson, R.C. - Cooper, M.K. - Vibhakar, R. - Hauser, P. - Veelen, M.L.C. van - Kros, J.M. - French, P.J. - Ra, Y.S. - Kumabe, T. - Lopez-Aguilar, E. - Zitterbart, Karel - Štěrba, Jaroslav - Finocchiaro, G. - Massimino, M. - Van Meir, E.G. - Osuka, S. - Shofuda, T. - Klekner, A. - Zollo, M. - Leonard, J.R. - Rubin, J.B. - Jabado, N. - Albrecht, S. - Mora, J. - Van Meter, T.E. - Jung, S. - Moore, A.S. - Hallahan, A.R. - Chan, J.A. - Tirapeli, D.C. - Carlotto, C.G. - Fouladi, M. - Pimentel, J. - Faria, C.C. - Saad, A.G. - Massimi, L. - Liau, L.M. - Wheeler, H. - Nakamura, H. - Elbabaa, S.K. - Perezpena Diazconti, M. - Ponce de León, F.C. - Robinson, S. - Zapotocky, M. - Lassaletta, A. - Huang, A. - Hawkins, C.E. - Tabori, U. - Bouffet, E. - Bartels, U. - Dirks, P.B. - Rutka, J.T. - Bader, G.D. - Reimand, J. - Goldenberg, A. - Ramaswamy, V. - Taylor, M.D. PY - 2017 TI - Intertumoral Heterogeneity within Medulloblastoma Subgroups JF - Cancer Cell VL - 31 IS - 6 SP - "737"-"+" EP - "737"-"+" PB - Cell Press SN - 15356108 KW - Intertumoral Heterogeneity N2 - While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials. ER -
CAVALLI, F.M.G.; M. REMKE; L. RAMPASEK; J. PEACOCK; D.J.H. SHIH; B. LUU; L. GARZIA; J. TORCHIA; C. NOR; A.S. MORRISSY; S. AGNIHOTRI; Y.Y. THOMPSON; C.M. KUZAN-FISCHER; H. FAROOQ; K. ISAEV; C. DANIELS; B.K. CHO; S.K. KIM; K.C. WANG; J.Y. LEE; W.A. GRAJKOWSKA; M. PEREK-POLNIK; A. VASILJEVIC; C. FAURE-CONTER; A. JOUVET; C. GIANNINI; A.A.N. RAO; K.K.W. LI; H.K. NG; C.G. EBERHART; I.F. POLLACK; R.L. HAMILTON; G.Y. GILLESPIE; J.M. OLSON; S. LEARY; W.A. WEISS; B. LACH; L.B. CHAMBLESS; R.C. THOMPSON; M.K. COOPER; R. VIBHAKAR; P. HAUSER; M.L.C. van VEELEN; J.M. KROS; P.J. FRENCH; Y.S. RA; T. KUMABE; E. LOPEZ-AGUILAR; Karel ZITTERBART; Jaroslav ŠTĚRBA; G. FINOCCHIARO; M. MASSIMINO; E.G. VAN MEIR; S. OSUKA; T. SHOFUDA; A. KLEKNER; M. ZOLLO; J.R. LEONARD; J.B. RUBIN; N. JABADO; S. ALBRECHT; J. MORA; T.E. VAN METER; S. JUNG; A.S. MOORE; A.R. HALLAHAN; J.A. CHAN; D.C. TIRAPELI; C.G. CARLOTTO; M. FOULADI; J. PIMENTEL; C.C. FARIA; A.G. SAAD; L. MASSIMI; L.M. LIAU; H. WHEELER; H. NAKAMURA; S.K. ELBABAA; M. PEREZPENA DIAZCONTI; F.C. PONCE DE LEÓN; S. ROBINSON; M. ZAPOTOCKY; A. LASSALETTA; A. HUANG; C.E. HAWKINS; U. TABORI; E. BOUFFET; U. BARTELS; P.B. DIRKS; J.T. RUTKA; G.D. BADER; J. REIMAND; A. GOLDENBERG; V. RAMASWAMY a M.D. TAYLOR. Intertumoral Heterogeneity within Medulloblastoma Subgroups. \textit{Cancer Cell}. Cambridge: Cell Press, 2017, roč.~31, č.~6, s.~''737''-''+'', 24 s. ISSN~1535-6108. Dostupné z: https://doi.org/10.1016/j.ccell.2017.05.005.