Predictive value of preoperative statistical parametric mapping
of regional glucose metabolism in mesial temporal lobe epilepsy
with hippocampal sclerosis

J 2018

Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis

KOJAN, Martin, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Radek MAREČEK, Zdeněk ŘEHÁK et. al.

Základní údaje

Originální název

Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis

Autoři

KOJAN, Martin (703 Slovensko, domácí), Irena DOLEŽALOVÁ (203 Česká republika, domácí), Eva KORIŤÁKOVÁ (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Zdeněk ŘEHÁK (203 Česká republika, domácí), Markéta HERMANOVÁ (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, garant, domácí)

Vydání

EPILEPSY & BEHAVIOR, Elsevier, 2018, 1525-5050

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.378

Kód RIV

RIV/00216224:14740/18:00102189

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.yebeh.2017.11.014

UT WoS

000426435800009

Klíčová slova anglicky

positron emission tomography; FDG-PET; mesial temporal lobe epilepsy; hippocampal sclerosis

Štítky

14110112, 14110127, 14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2019 16:39, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

OBJECTIVE: This study was designed to use statistical parametric mapping of interictal positron-emission tomography using [18F]Fluorodeoxyglucose (FDG-PET) to compare the brain metabolisms of patients with mesial temporal lobe epilepsy (MTLE)/hippocampal sclerosis and controls. Another aim of this study was to analyze the potential differences among patients in terms of epilepsy duration, side of hippocampal sclerosis, histopathological findings, insult in their history, and postoperative outcomes. METHODS: We analyzed FDG-PET scans from 49 patients with MTLE/hippocampal sclerosis and 24 control subjects. We analyzed the differences in regional glucose metabolism between the patients and the control group and within the patient group using multiple variables. RESULTS: We observed widespread hypometabolism in the patient group in comparison with the control group in temporal and extratemporal areas on the epileptogenic side (ES). On the nonepileptogenic side (NES), we observed the most hypometabolism in the thalamus and the anterior and middle cingulate gyrus. In the group of patients with more severe hippocampal sclerosis, we observed statistically significant hypometabolism in the insula on the ES. In patients with poor postoperative outcomes, we found statistically significant hypometabolism in the insula on the ES and the temporal pole (TP) on the NES. Patients with any insult in their history showed hypermetabolism in the TP on both sides. CONCLUSION: Our study showed that there are widespread changes in metabolism in patients with MTLE in comparison to controls, either inside or outside the temporal lobe. There are significant differences among these patients in terms of postoperative outcomes, degree of hippocampal sclerosis, and insults in their history.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

KOJAN, Martin, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Radek MAREČEK, Zdeněk ŘEHÁK, Markéta HERMANOVÁ, Milan BRÁZDIL a Ivan REKTOR. Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. EPILEPSY & BEHAVIOR. Elsevier, 2018, roč. 79, DEC, s. 46-52. ISSN 1525-5050. Dostupné z: https://dx.doi.org/10.1016/j.yebeh.2017.11.014.

@article{1403104,
   author = {Kojan, Martin and Doležalová, Irena and Koriťáková, Eva and Mareček, Radek and Řehák, Zdeněk and Hermanová, Markéta and Brázdil, Milan and Rektor, Ivan},
   article_number = {DEC},
   doi = {http://dx.doi.org/10.1016/j.yebeh.2017.11.014},
   keywords = {positron emission tomography; FDG-PET; mesial temporal lobe epilepsy; hippocampal sclerosis},
   language = {eng},
   issn = {1525-5050},
   journal = {EPILEPSY & BEHAVIOR},
   title = {Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis},
   url = {http://www.sciencedirect.com/science/article/pii/S1525505017305267?via%3Dihub},
   volume = {79},
   year = {2018}
}

TY  - JOUR
ID  - 1403104
AU  - Kojan, Martin - Doležalová, Irena - Koriťáková, Eva - Mareček, Radek - Řehák, Zdeněk - Hermanová, Markéta - Brázdil, Milan - Rektor, Ivan
PY  - 2018
TI  - Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis
JF  - EPILEPSY & BEHAVIOR
VL  - 79
IS  - DEC
SP  - 46-52
EP  - 46-52
PB  - Elsevier
SN  - 15255050
KW  - positron emission tomography
KW  - FDG-PET
KW  - mesial temporal lobe epilepsy
KW  - hippocampal sclerosis
UR  - http://www.sciencedirect.com/science/article/pii/S1525505017305267?via%3Dihub
N2  - OBJECTIVE: This study was designed to use statistical parametric mapping of interictal positron-emission tomography using [18F]Fluorodeoxyglucose (FDG-PET) to compare the brain metabolisms of patients with mesial temporal lobe epilepsy (MTLE)/hippocampal sclerosis and controls. Another aim of this study was to analyze the potential differences among patients in terms of epilepsy duration, side of hippocampal sclerosis, histopathological findings, insult in their history, and postoperative outcomes. METHODS: We analyzed FDG-PET scans from 49 patients with MTLE/hippocampal sclerosis and 24 control subjects. We analyzed the differences in regional glucose metabolism between the patients and the control group and within the patient group using multiple variables. RESULTS: We observed widespread hypometabolism in the patient group in comparison with the control group in temporal and extratemporal areas on the epileptogenic side (ES). On the nonepileptogenic side (NES), we observed the most hypometabolism in the thalamus and the anterior and middle cingulate gyrus. In the group of patients with more severe hippocampal sclerosis, we observed statistically significant hypometabolism in the insula on the ES. In patients with poor postoperative outcomes, we found statistically significant hypometabolism in the insula on the ES and the temporal pole (TP) on the NES. Patients with any insult in their history showed hypermetabolism in the TP on both sides. CONCLUSION: Our study showed that there are widespread changes in metabolism in patients with MTLE in comparison to controls, either inside or outside the temporal lobe. There are significant differences among these patients in terms of postoperative outcomes, degree of hippocampal sclerosis, and insults in their history.
ER  -

KOJAN, Martin, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Radek MAREČEK, Zdeněk ŘEHÁK, Markéta HERMANOVÁ, Milan BRÁZDIL a Ivan REKTOR. Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. \textit{EPILEPSY \&{} BEHAVIOR}. Elsevier, 2018, roč.~79, DEC, s.~46-52. ISSN~1525-5050. Dostupné z: https://dx.doi.org/10.1016/j.yebeh.2017.11.014.

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