A to I editing in disease is not fake news

J 2017

A to I editing in disease is not fake news

BAJAD, P.; MF JANTSCH; Liam KEEGAN a Mary Anne O'CONNELL

Základní údaje

Originální název

A to I editing in disease is not fake news

Autoři

BAJAD, P.; MF JANTSCH; Liam KEEGAN a Mary Anne O'CONNELL

Vydání

RNA BIOLOGY, PHILADELPHIA, TAYLOR & FRANCIS INC, 2017, 1547-6286

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.216

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/17:00100305

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

Adenosine deaminases acting on RNA; Aicardi Guitieres Syndrome; RNA-editing; self versus non-self; target editing

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2018 10:56, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Adenosine deaminases acting on RNA (ADARs) are zinc-containing enzymes that deaminate adenosine bases to inosines within dsRNA regions in transcripts. In short, structured dsRNA hairpins individual adenosine bases may be targeted specifically and edited with up to one hundred percent efficiency, leading to the production of alternative protein variants. However, the majority of editing events occur within longer stretches of dsRNA formed by pairing of repetitive sequences. Here, many different adenosine bases are potential targets but editing efficiency is usually much lower. Recent work shows that ADAR-mediated RNA editing is also required to prevent aberrant activation of antiviral innate immune sensors that detect viral dsRNA in the cytoplasm. Missense mutations in the ADAR1 RNA editing enzyme cause a fatal auto-inflammatory disease, Aicardi-Goutieres syndrome (AGS) in affected children. In addition RNA editing by ADARs has been observed to increase in many cancers and also can contribute to vascular disease. Thus the role of RNA editing in the progression of various diseases can no longer be ignored. The ability of ADARs to alter the sequence of RNAs has also been used to artificially target model RNAs in vitro and in cells for RNA editing. Potentially this approach may be used to repair genetic defects and to alter genetic information at the RNA level. In this review we focus on the role of ADARs in disease development and progression and on their potential use to artificially modify RNAs in a targeted manner.

Návaznosti

621368, interní kód MU

Název: The ERA Chair Culture as a Catalyst to Maximize the Potential of CEITEC (Akronym: CEITEC_ERA)

Investor: Evropská unie, The ERA Chair Culture as a Catalyst to Maximize the Potential of CEITEC, Kapacity

Citovat

BAJAD, P.; MF JANTSCH; Liam KEEGAN a Mary Anne O'CONNELL. A to I editing in disease is not fake news. RNA BIOLOGY. PHILADELPHIA: TAYLOR & FRANCIS INC, 2017, roč. 14, č. 9, s. 1223-1231. ISSN 1547-6286. Dostupné z: https://doi.org/10.1080/15476286.2017.1306173.

@article{1410891,
   author = {Bajad, P. and Jantsch, MF and Keegan, Liam and O'Connell, Mary Anne},
   article_location = {PHILADELPHIA},
   article_number = {9},
   doi = {https://doi.org/10.1080/15476286.2017.1306173},
   keywords = {Adenosine deaminases acting on RNA; Aicardi Guitieres Syndrome; RNA-editing; self versus non-self; target editing},
   language = {eng},
   issn = {1547-6286},
   journal = {RNA BIOLOGY},
   title = {A to I editing in disease is not fake news},
   url = {http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5699539&blobtype=pdf},
   volume = {14},
   year = {2017}
}

TY  - JOUR
ID  - 1410891
AU  - Bajad, P. - Jantsch, MF - Keegan, Liam - O'Connell, Mary Anne
PY  - 2017
TI  - A to I editing in disease is not fake news
JF  - RNA BIOLOGY
VL  - 14
IS  - 9
SP  - 1223-1231
EP  - 1223-1231
PB  - TAYLOR & FRANCIS INC
SN  - 15476286
KW  - Adenosine deaminases acting on RNA
KW  - Aicardi Guitieres Syndrome
KW  - RNA-editing
KW  - self versus non-self
KW  - target editing
UR  - http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5699539&blobtype=pdf
L2  - http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5699539&blobtype=pdf
N2  - Adenosine deaminases acting on RNA (ADARs) are zinc-containing enzymes that deaminate adenosine bases to inosines within dsRNA regions in transcripts. In short, structured dsRNA hairpins individual adenosine bases may be targeted specifically and edited with up to one hundred percent efficiency, leading to the production of alternative protein variants. However, the majority of editing events occur within longer stretches of dsRNA formed by pairing of repetitive sequences. Here, many different adenosine bases are potential targets but editing efficiency is usually much lower. Recent work shows that ADAR-mediated RNA editing is also required to prevent aberrant activation of antiviral innate immune sensors that detect viral dsRNA in the cytoplasm. Missense mutations in the ADAR1 RNA editing enzyme cause a fatal auto-inflammatory disease, Aicardi-Goutieres syndrome (AGS) in affected children. In addition RNA editing by ADARs has been observed to increase in many cancers and also can contribute to vascular disease. Thus the role of RNA editing in the progression of various diseases can no longer be ignored. The ability of ADARs to alter the sequence of RNAs has also been used to artificially target model RNAs in vitro and in cells for RNA editing. Potentially this approach may be used to repair genetic defects and to alter genetic information at the RNA level. In this review we focus on the role of ADARs in disease development and progression and on their potential use to artificially modify RNAs in a targeted manner.
ER  -

BAJAD, P.; MF JANTSCH; Liam KEEGAN a Mary Anne O'CONNELL. A to I editing in disease is not fake news. \textit{RNA BIOLOGY}. PHILADELPHIA: TAYLOR \&{}amp; FRANCIS INC, 2017, roč.~14, č.~9, s.~1223-1231. ISSN~1547-6286. Dostupné z: https://doi.org/10.1080/15476286.2017.1306173.

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