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@article{1419293,
author = {Wangmo, Chimi and Jarque Ortiz, Sergio and Hilscherová, Klára and Bláha, Luděk and Bittner, Michal},
article_location = {CAMBRIDGE},
article_number = {2},
doi = {http://dx.doi.org/10.1039/c7em00458c},
keywords = {MUNICIPAL WASTE-WATER; TREATMENT-PLANT EFFLUENTS; SEWAGE-TREATMENT PLANT; ENDOCRINE DISRUPTING CHEMICALS; MULTIPLE HORMONAL ACTIVITIES; HYDRAULIC FRACTURING CHEMICALS; DISSOLVED ORGANIC-MATTER},
language = {eng},
issn = {2050-7887},
journal = {ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS},
title = {In vitro assessment of sex steroids and related compounds in water and sediments - a critical review},
url = {http://pubs.rsc.org/en/Content/ArticleLanding/2018/EM/C7EM00458C#!divAbstract},
volume = {20},
year = {2018}
}
TY - JOUR
ID - 1419293
AU - Wangmo, Chimi - Jarque Ortiz, Sergio - Hilscherová, Klára - Bláha, Luděk - Bittner, Michal
PY - 2018
TI - In vitro assessment of sex steroids and related compounds in water and sediments - a critical review
JF - ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
VL - 20
IS - 2
SP - 270-287
EP - 270-287
PB - ROYAL SOC CHEMISTRY
SN - 20507887
KW - MUNICIPAL WASTE-WATER
KW - TREATMENT-PLANT EFFLUENTS
KW - SEWAGE-TREATMENT PLANT
KW - ENDOCRINE DISRUPTING CHEMICALS
KW - MULTIPLE HORMONAL ACTIVITIES
KW - HYDRAULIC FRACTURING CHEMICALS
KW - DISSOLVED ORGANIC-MATTER
UR - http://pubs.rsc.org/en/Content/ArticleLanding/2018/EM/C7EM00458C#!divAbstract
L2 - http://pubs.rsc.org/en/Content/ArticleLanding/2018/EM/C7EM00458C#!divAbstract
N2 - Detection of endocrine disrupting compounds in water and sediment samples has gained much importance since the evidence of their effects was reported in aquatic ecosystems in the 1990s. The aim of this review is to highlight the advances made in the field of in vitro analysis for the detection of hormonally active compounds with estrogenic, androgenic and progestogenic effects in water and sediment samples. In vitro assays have been developed from yeast, mammalian and in a few cases from fish cells. These assays are based either on the hormone-mediated proliferation of sensitive cell lines or on the hormone-mediated expression of reporter genes. In vitro assays in combination with various sample enrichment methods have been used with limits of detection as low as 0.0027 ng L (1) in water, and 0.0026 ng g(-1) in sediments for estrogenicity, 0.1 ng L-1 in water, and 0.5 ng g(-1) in sediments for androgenicity, and 5 ng L-1 in water for progestogenicity expressed as equivalent concentrations of standard reference compounds of 17 beta-estradiol, dihydrotestosterone and progesterone, respectively. The experimental results and limits of quantification, however, are influenced by the methods of sample collection, preparation, and individual laboratory practices.
ER -
WANGMO, Chimi, Sergio JARQUE ORTIZ, Klára HILSCHEROVÁ, Luděk BLÁHA a Michal BITTNER. In vitro assessment of sex steroids and related compounds in water and sediments - a critical review. \textit{ENVIRONMENTAL SCIENCE-PROCESSES \&{}amp; IMPACTS}. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2018, roč.~20, č.~2, s.~270-287. ISSN~2050-7887. Dostupné z: https://dx.doi.org/10.1039/c7em00458c.
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