Recurrent aphthous stomatitis and gene variability in selected
interleukins

a 2018

Recurrent aphthous stomatitis and gene variability in selected interleukins

BOŘILOVÁ LINHARTOVÁ, Petra; Július JÁNOŠ; Simona SLEZÁKOVÁ; Jiřina BÁRTOVÁ; Jitka PETANOVÁ et. al.

Základní údaje

Originální název

Recurrent aphthous stomatitis and gene variability in selected interleukins

Autoři

BOŘILOVÁ LINHARTOVÁ, Petra; Július JÁNOŠ; Simona SLEZÁKOVÁ; Jiřina BÁRTOVÁ; Jitka PETANOVÁ; Pavel KUKLÍNEK; Antonín FASSMANN; Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ

Vydání

FDI 2018 World Dental Congress 2018, Buenos Aires, 2018

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.628

Kód RIV

RIV/00216224:14110/18:00101193

Organizační jednotka

Lékařská fakulta

ISSN

Klíčová slova anglicky

association studies; candidate gene; genetic; immunity; oral ulcer; polymorphisms

Změněno: 15. 1. 2019 15:46, Mgr. et Mgr. Simona Slezáková, Ph.D.

Anotace

V originále

Genetic factors, especially those related to the immune system functioning, have been intensively studied for their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukins (ILs): IL-2, IL-4 and its receptor alpha (IL-4R alpha), IL-10 and IL-13, which were selected based on the literature review and/or their functional relevance, in Czech patients with RAS and healthy controls. Generally, 252 subjects were enrolled in this case-control study (178 controls and 74 patients with RAS) and their detail anamnestic, clinical and laboratory data were obtained. Nine polymorphisms in the genes encoding ILs were determined by PCR techniques. There were no significant differences in allele or genotype frequencies of the studied polymorphisms IL-2 (rs2069762 and rs2069763), IL-4 (rs2243250 and rs79071878), IL-4R alpha (rs1801275), IL-10 (rs1800896), and IL-13 (rs1800925) between the controls and RAS patients. The minority alleles of the IL-10 (rs1800871 and rs1800872) variants were associated with a higher risk of RAS , as confirmed by the results of genotype and haplotype analysis. We suggest that variability in the IL-10 gene may play an important role in the RAS development in the Czech population.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

MUNI/A/1008/2017, interní kód MU

Název: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní

Investor: Masarykova univerzita, Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

NV15-29336A, projekt VaV

Název: Změny imunologické reaktivity u pacientů s recidivujícími aftami

ROZV/24/LF/2018, interní kód MU

Název: LF - Příspěvek na IP 2108

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek na IP 2108, Interní rozvojové projekty

Citovat

BOŘILOVÁ LINHARTOVÁ, Petra; Július JÁNOŠ; Simona SLEZÁKOVÁ; Jiřina BÁRTOVÁ; Jitka PETANOVÁ; Pavel KUKLÍNEK; Antonín FASSMANN; Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Recurrent aphthous stomatitis and gene variability in selected interleukins. In FDI 2018 World Dental Congress 2018, Buenos Aires. 2018. ISSN 0020-6539.

@proceedings{1439478,
   author = {Bořilová Linhartová, Petra and Jánoš, Július and Slezáková, Simona and Bártová, Jiřina and Petanová, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Dušek, Ladislav and Izakovičová Hollá, Lydie},
   booktitle = {FDI 2018 World Dental Congress 2018, Buenos Aires},
   keywords = {association studies; candidate gene; genetic; immunity; oral ulcer; polymorphisms},
   language = {eng},
   title = {Recurrent aphthous stomatitis and gene variability in selected interleukins},
   year = {2018}
}

TY  - CONF
ID  - 1439478
AU  - Bořilová Linhartová, Petra - Jánoš, Július - Slezáková, Simona - Bártová, Jiřina - Petanová, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY  - 2018
TI  - Recurrent aphthous stomatitis and gene variability in selected interleukins
KW  - association studies
KW  - candidate gene
KW  - genetic
KW  - immunity
KW  - oral ulcer
KW  - polymorphisms
N2  - Genetic factors, especially those related to the immune system functioning, have been intensively studied for their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukins (ILs): IL-2, IL-4 and its receptor alpha (IL-4R alpha), IL-10 and IL-13, which were selected based on the literature review and/or their functional relevance, in Czech patients with RAS and healthy controls. Generally, 252 subjects were enrolled in this case-control study (178 controls and 74 patients with RAS) and their detail anamnestic, clinical and laboratory data were obtained. Nine polymorphisms in the genes encoding ILs were determined by PCR techniques. There were no significant differences in allele or genotype frequencies of the studied polymorphisms IL-2 (rs2069762 and rs2069763), IL-4 (rs2243250 and rs79071878), IL-4R alpha (rs1801275), IL-10 (rs1800896), and IL-13 (rs1800925) between the controls and RAS patients. The minority alleles of the IL-10 (rs1800871 and rs1800872) variants were associated with a higher risk of RAS , as confirmed by the results of genotype and haplotype analysis. We suggest that variability in the IL-10 gene may play an important role in the RAS development in the Czech population.
ER  -

BOŘILOVÁ LINHARTOVÁ, Petra; Július JÁNOŠ; Simona SLEZÁKOVÁ; Jiřina BÁRTOVÁ; Jitka PETANOVÁ; Pavel KUKLÍNEK; Antonín FASSMANN; Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Recurrent aphthous stomatitis and gene variability in selected interleukins. In \textit{FDI 2018 World Dental Congress 2018, Buenos Aires}. 2018. ISSN~0020-6539.

Přehled o publikaci