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@article{1450356,
author = {Minář, Luboš and Felsinger, Michal and Číhalová, Marta and Zlámal, Filip and Bienertová Vašků, Julie},
article_location = {GDANSK},
article_number = {8},
doi = {http://dx.doi.org/10.5603/GP.a2018.0073},
keywords = {squamous cell vulvar cancer; surgical treatment; tumour-free pathological margins; local recurrence},
language = {eng},
issn = {0017-0011},
journal = {GINEKOLOGIA POLSKA},
title = {Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group},
volume = {89},
year = {2018}
}
TY - JOUR
ID - 1450356
AU - Minář, Luboš - Felsinger, Michal - Číhalová, Marta - Zlámal, Filip - Bienertová Vašků, Julie
PY - 2018
TI - Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group
JF - GINEKOLOGIA POLSKA
VL - 89
IS - 8
SP - 424-431
EP - 424-431
PB - VIA MEDICA
SN - 00170011
KW - squamous cell vulvar cancer
KW - surgical treatment
KW - tumour-free pathological margins
KW - local recurrence
N2 - Objectives:To evaluate risk factors associated with the local recurrence of invasive squamous cell vulvar cancer in patient group with tumor-free pathological margins. Material and methods: This is a retrospective analysis of 47 patients who underwent surgical treatment at University Hospital Brno, the Czech Republic between 2007 and 2014. 24 patients were classified as IB stage and three as II stage. A further 20 patients representing stage III showed the metastatic involvement of regional lymph nodes. Seven prognostic factors were analyzed in relation to local tumour recurrence: tumour size, margin distance, depth of invasion, lymphovascular space involvement (LVSI), midline involvement, metastatic lymph nodes and FIGO stage. Results: All prognostic factors were found to be statistically significant with respect to the risk of local recurrence. The highest risk of local recurrence was observed for the depth of invasion > 5 mm (HR, 12.42 [95% CI; 3.44-44.841) and for the presence of LVSI (HR, 10.83 [95% CI; 3.87-30.28]).The study also established a clear difference in the risk of local recurrence between patient groups with resection margin < 8 vs. >= 8 mm (HR, 4.91 [95% CI; 1.73-13.93; p = 0.003]. Conclusions: Tumour-free pathological margin of >= 8 mm is a major prognostic factor of local recurrence which can be influenced by the surgeon. A perfect knowledge of the extent of the disease prior to surgery supports adequately radical surgical trends. The emphasis is given on adequate radicality as well as on the reduction of overtreatment without worsening prognosis by simultaneously preserving the quality of life.
ER -
MINÁŘ, Luboš, Michal FELSINGER, Marta ČÍHALOVÁ, Filip ZLÁMAL a Julie BIENERTOVÁ VAŠKŮ. Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group. \textit{GINEKOLOGIA POLSKA}. GDANSK: VIA MEDICA, roč.~89, č.~8, s.~424-431. ISSN~0017-0011. doi:10.5603/GP.a2018.0073. 2018.
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