ADAR RNA editing in innate immune response phasing, in
circadian clocks and in sleep

J 2019

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep

SINIGAGLIA, Ketty; Dagmara WIATREK; Anzer KHAN; David MICHALÍK; Nagraj SAMBRANI et al.

Základní údaje

Originální název

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep

Autoři

SINIGAGLIA, Ketty; Dagmara WIATREK; Anzer KHAN; David MICHALÍK; Nagraj SAMBRANI; Jiří SEDMÍK ; Dragana VUKIĆ; Mary Anne O'CONNELL a Liam KEEGAN

Vydání

Biochimica et biophysica acta - Gene regulatory mechanisms, Amsterdam, Elsevier, 2019, 1874-9399

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Full Text

Impakt faktor

Impact factor: 3.510

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/19:00108913

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

ADAR; RNA editing; dsRNA; microRNA; Epitranscriptome; Innate immunity; Circadian rhythm; Sleep

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2020 19:58, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in dsRNA. ADAR editing in premRNAs recodes open reading frames and alters splicing, mRNA structure and interactions with miRNAs. Here, we review ADAR gene expression, splice forms, posttranslational modifications, subcellular localizations and functions of ADAR protein isoforms. ADAR1 edits cellular dsRNA to prevent aberrant activation of cytoplasmic antiviral dsRNA sensors; ADAR1 mutations lead to aberrant expression of interferon in Aicardi Goutieres syndrome (AGS), a human congenital encephalopathy. We review related studies on mouse Adarl mutant phenotypes, their rescues by preventing signaling from the antiviral RIG-I-like Sensors (RLRs), as well as Marl mechanisms in innate immune suppression and other roles of Adarl, including editing-independent effects. ADAR2, expressed primarily in CNS, edits glutamate receptor transcripts; regulation of ADAR2 activity in response to neuronal activity mediates homeostatic synaptic plasticity of vertebrate AMPA and kainite receptors. In Drosophila, synapses and synaptic proteins show dramatic decreases at night during sleep; Drosophila Adar, an orthologue of ADAR2, edits hundreds of mRNAs; the most conserved editing events occur in transcripts encoding synapse-associated proteins. Adar mutant flies exhibit locomotion defects associated with very increased sleep pressure resulting from a failure of homeostatic synaptic processes. A study on Adcir2 mutant mice identifies a new role in circadian rhythms, acting indirectly through miRNAs such as let-7 to modulate levels of let-7 target mRNAs; ADAR1 also regulates let-7 miRNA processing. Drosophila ADAR, an orthologue of vertebrate ADAR2, also regulates let-7 miRNA levels and Adar mutant flies have a circadian mutant phenotype.

Návaznosti

LTC18052, projekt VaV

Název: Integrativní studium molekulárních mechanismů epitranskriptomu savčích buněk

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Integrativní studium molekulárních mechanismů epitranskriptomu savčích buněk, INTER-COST

621368, interní kód MU

Název: The ERA Chair Culture as a Catalyst to Maximize the Potential of CEITEC (Akronym: CEITEC_ERA)

Investor: Evropská unie, The ERA Chair Culture as a Catalyst to Maximize the Potential of CEITEC, Kapacity

Citovat

SINIGAGLIA, Ketty; Dagmara WIATREK; Anzer KHAN; David MICHALÍK; Nagraj SAMBRANI; Jiří SEDMÍK; Dragana VUKIĆ; Mary Anne O'CONNELL a Liam KEEGAN. ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep. Biochimica et biophysica acta - Gene regulatory mechanisms. Amsterdam: Elsevier, 2019, roč. 1862, č. 3, s. 356-369. ISSN 1874-9399. Dostupné z: https://doi.org/10.1016/j.bbagrm.2018.10.011.

@article{1463776,
   author = {Sinigaglia, Ketty and Wiatrek, Dagmara and Khan, Anzer and Michalík, David and Sambrani, Nagraj and Sedmík, Jiří and Vukić, Dragana and O'Connell, Mary Anne and Keegan, Liam},
   article_location = {Amsterdam},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.bbagrm.2018.10.011},
   keywords = {ADAR; RNA editing; dsRNA; microRNA; Epitranscriptome; Innate immunity; Circadian rhythm; Sleep},
   language = {eng},
   issn = {1874-9399},
   journal = {Biochimica et biophysica acta - Gene regulatory mechanisms},
   title = {ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep},
   url = {https://www.sciencedirect.com/science/article/pii/S1874939918302323},
   volume = {1862},
   year = {2019}
}

TY  - JOUR
ID  - 1463776
AU  - Sinigaglia, Ketty - Wiatrek, Dagmara - Khan, Anzer - Michalík, David - Sambrani, Nagraj - Sedmík, Jiří - Vukić, Dragana - O'Connell, Mary Anne - Keegan, Liam
PY  - 2019
TI  - ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep
JF  - Biochimica et biophysica acta - Gene regulatory mechanisms
VL  - 1862
IS  - 3
SP  - 356-369
EP  - 356-369
PB  - Elsevier
SN  - 18749399
KW  - ADAR
KW  - RNA editing
KW  - dsRNA
KW  - microRNA
KW  - Epitranscriptome
KW  - Innate immunity
KW  - Circadian rhythm
KW  - Sleep
UR  - https://www.sciencedirect.com/science/article/pii/S1874939918302323
L2  - https://www.sciencedirect.com/science/article/pii/S1874939918302323
N2  - Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in dsRNA. ADAR editing in premRNAs recodes open reading frames and alters splicing, mRNA structure and interactions with miRNAs. Here, we review ADAR gene expression, splice forms, posttranslational modifications, subcellular localizations and functions of ADAR protein isoforms. ADAR1 edits cellular dsRNA to prevent aberrant activation of cytoplasmic antiviral dsRNA sensors; ADAR1 mutations lead to aberrant expression of interferon in Aicardi Goutieres syndrome (AGS), a human congenital encephalopathy. We review related studies on mouse Adarl mutant phenotypes, their rescues by preventing signaling from the antiviral RIG-I-like Sensors (RLRs), as well as Marl mechanisms in innate immune suppression and other roles of Adarl, including editing-independent effects. ADAR2, expressed primarily in CNS, edits glutamate receptor transcripts; regulation of ADAR2 activity in response to neuronal activity mediates homeostatic synaptic plasticity of vertebrate AMPA and kainite receptors. In Drosophila, synapses and synaptic proteins show dramatic decreases at night during sleep; Drosophila Adar, an orthologue of ADAR2, edits hundreds of mRNAs; the most conserved editing events occur in transcripts encoding synapse-associated proteins. Adar mutant flies exhibit locomotion defects associated with very increased sleep pressure resulting from a failure of homeostatic synaptic processes. A study on Adcir2 mutant mice identifies a new role in circadian rhythms, acting indirectly through miRNAs such as let-7 to modulate levels of let-7 target mRNAs; ADAR1 also regulates let-7 miRNA processing. Drosophila ADAR, an orthologue of vertebrate ADAR2, also regulates let-7 miRNA levels and Adar mutant flies have a circadian mutant phenotype.
ER  -

SINIGAGLIA, Ketty; Dagmara WIATREK; Anzer KHAN; David MICHALÍK; Nagraj SAMBRANI; Jiří SEDMÍK; Dragana VUKI$\backslash$'C; Mary Anne O'CONNELL a Liam KEEGAN. ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep. \textit{Biochimica et biophysica acta - Gene regulatory mechanisms}. Amsterdam: Elsevier, 2019, roč.~1862, č.~3, s.~356-369. ISSN~1874-9399. Dostupné z: https://doi.org/10.1016/j.bbagrm.2018.10.011.

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