FILIP, Pavel, Pavla LINHARTOVÁ, Pavlína HLAVATÁ, Rastislav ŠUMEC, Marek BALÁŽ, Martin BAREŠ a Tomáš KAŠPÁREK. Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson's Disease. Frontiers in Human Neuroscience. Lausanne: Frontiers Research Foundation, 2018, roč. 12, č. 462, s. 1-13. ISSN 1662-5161. doi:10.3389/fnhum.2018.00462.
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Základní údaje
Originální název Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson's Disease
Autoři FILIP, Pavel (703 Slovensko, garant, domácí), Pavla LINHARTOVÁ (203 Česká republika, domácí), Pavlína HLAVATÁ (203 Česká republika, domácí), Rastislav ŠUMEC (703 Slovensko, domácí), Marek BALÁŽ (703 Slovensko, domácí), Martin BAREŠ (203 Česká republika, domácí) a Tomáš KAŠPÁREK (203 Česká republika, domácí).
Vydání Frontiers in Human Neuroscience, Lausanne, Frontiers Research Foundation, 2018, 1662-5161.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 50101 Psychology
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 2.870
Kód RIV RIV/00216224:14110/18:00106960
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.3389/fnhum.2018.00462
UT WoS 000450959000001
Klíčová slova anglicky impulse control disorder; Parkinson's disease; fMRI; functional connectivity; Go/No Go task; delay discounting task
Štítky 14110127, 14110222, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 9. 2. 2019 22:15.
Anotace
The phenomenon of impulsivity in Parkinson's disease appears as an arduous side effect of dopaminergic therapy with potentially detrimental consequences for the life of the patients. Although conceptualized as a result of non-physiologic chronic dopaminergic stimulation, recent advances speculate on combined disruption of other networks as well. In the search for neuroanatomical correlates of this multifaceted disturbance, this study employs two distinct, well-defined tasks of close association tomotor inhibition and decision-making impulsivity, Go/ No Go and Delay discounting. The fMRI and functional connectivity analysis in 21 Parkinson's disease patients, including 8 patients suffering from severe impulse control disorder, and 28 healthy controls, revealed in impulsive Parkinson's disease patients not only decreased fMRI activation in the dorsolateral prefrontal cortex and bilateral striatum, but also vast functional connectivity changes of both caudate nuclei as decreased connectivity to the superior parietal cortex and increased connectivity to the insular area, clearly beyond the commonly stated areas, which indicates that orbitofronto-striatal and mesolimbic functional disruptions are not the sole mechanisms underlying impulse control disorder in Parkinson's disease. Ergo, our results present a refinement and synthesis of gradually developing ideas about the nature of impulsive control disorder in Parkinson's disease-an umbrella term encompassing various behavioral deviations related to distinct neuronal networks and presumably neurotransmitter systems, which greatly exceed the previously envisioned dopaminergic pathways as the only culprit.
Návaznosti
NV15-30062A, projekt VaVNázev: Fenotypy impulzivity u neuropsychiatrických poruch a jejich klinický význam
VytisknoutZobrazeno: 8. 5. 2021 07:03