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@article{1484323,
author = {Filip, Pavel and Linhartová, Pavla and Hlavatá, Pavlína and Šumec, Rastislav and Baláž, Marek and Bareš, Martin and Kašpárek, Tomáš},
article_location = {Lausanne},
article_number = {462},
doi = {http://dx.doi.org/10.3389/fnhum.2018.00462},
keywords = {impulse control disorder; Parkinson's disease; fMRI; functional connectivity; Go/No Go task; delay discounting task},
language = {eng},
issn = {1662-5161},
journal = {Frontiers in Human Neuroscience},
title = {Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson's Disease},
volume = {12},
year = {2018}
}
TY - JOUR
ID - 1484323
AU - Filip, Pavel - Linhartová, Pavla - Hlavatá, Pavlína - Šumec, Rastislav - Baláž, Marek - Bareš, Martin - Kašpárek, Tomáš
PY - 2018
TI - Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson's Disease
JF - Frontiers in Human Neuroscience
VL - 12
IS - 462
SP - 1-13
EP - 1-13
PB - Frontiers Research Foundation
SN - 16625161
KW - impulse control disorder
KW - Parkinson's disease
KW - fMRI
KW - functional connectivity
KW - Go/No Go task
KW - delay discounting task
N2 - The phenomenon of impulsivity in Parkinson's disease appears as an arduous side effect of dopaminergic therapy with potentially detrimental consequences for the life of the patients. Although conceptualized as a result of non-physiologic chronic dopaminergic stimulation, recent advances speculate on combined disruption of other networks as well. In the search for neuroanatomical correlates of this multifaceted disturbance, this study employs two distinct, well-defined tasks of close association tomotor inhibition and decision-making impulsivity, Go/ No Go and Delay discounting. The fMRI and functional connectivity analysis in 21 Parkinson's disease patients, including 8 patients suffering from severe impulse control disorder, and 28 healthy controls, revealed in impulsive Parkinson's disease patients not only decreased fMRI activation in the dorsolateral prefrontal cortex and bilateral striatum, but also vast functional connectivity changes of both caudate nuclei as decreased connectivity to the superior parietal cortex and increased connectivity to the insular area, clearly beyond the commonly stated areas, which indicates that orbitofronto-striatal and mesolimbic functional disruptions are not the sole mechanisms underlying impulse control disorder in Parkinson's disease. Ergo, our results present a refinement and synthesis of gradually developing ideas about the nature of impulsive control disorder in Parkinson's disease-an umbrella term encompassing various behavioral deviations related to distinct neuronal networks and presumably neurotransmitter systems, which greatly exceed the previously envisioned dopaminergic pathways as the only culprit.
ER -
FILIP, Pavel, Pavla LINHARTOVÁ, Pavlína HLAVATÁ, Rastislav ŠUMEC, Marek BALÁŽ, Martin BAREŠ a Tomáš KAŠPÁREK. Disruption of Multiple Distinctive Neural Networks Associated With Impulse Control Disorder in Parkinson's Disease. \textit{Frontiers in Human Neuroscience}. Lausanne: Frontiers Research Foundation, 2018, roč.~12, č.~462, s.~1-13. ISSN~1662-5161. Dostupné z: https://dx.doi.org/10.3389/fnhum.2018.00462.
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