Prioritization of hazards of novel flame retardants using the
mechanistic toxicology information from ToxCast and Adverse
Outcome Pathways

J 2019

Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

BAJARD ÉP.ESNER, Lola Murielle, Lisa Emily MELYMUK a Luděk BLÁHA

Základní údaje

Originální název

Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

Autoři

BAJARD ÉP.ESNER, Lola Murielle (250 Francie, domácí), Lisa Emily MELYMUK (124 Kanada, domácí) a Luděk BLÁHA (203 Česká republika, garant, domácí)

Vydání

Environmental Sciences Europe, HEIDELBERG, GERMANY, Springer-Verlag, GmbH, Environmental Sciences Europe, 2019, 2190-4715

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Full Text

Impakt faktor

Impact factor: 5.394

Kód RIV

RIV/00216224:14310/19:00110362

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1186/s12302-019-0195-z

UT WoS

000459786300001

Klíčová slova anglicky

Flame retardants; ToxCast; AOP; Prioritization; Hazard; Mechanisms of toxicity

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 5. 2020 09:09, RNDr. Kateřina Nováková, Ph.D.

Anotace

V originále

BackgroundFlame retardants (FRs) are used in most consumer products and textiles to comply with current flammability standards. After the restriction of polybrominated diphenyl ethers, a large number of chemically diverse replacement FRs are increasingly used, but the risk they represent is not yet properly evaluated and their toxicity pathways are still poorly understood.ApproachWe collected in vivo toxicological information on 62 (including 52 non-regulated) FRs and established five prioritization categories (Cat I to V) based on data availability and toxicological concern. We then considered available in vitro toxicological data from ToxCast, as a complement to in vivo information. By combining these information sources, we then explored relevant toxicity mechanisms for nine selected FRs (Cat I) using the AOP (Adverse Outcome Pathway) framework.ResultsFor 20 FRs (Cat V), toxicological data on mammals were absent. Data available were scarce for another 22 FRs, of which 14 FRs (Cat II) may be of toxicological concern. We found substantial information for only ten replacement FRs, of which nine (Cat I) present some toxicological concern: tris-2-chloroethyl phosphate (TCEP), tris(1,3-dichloropropyl)phosphate (TDCIPP), triphenyl phosphate (TPhP), tricresyl phosphate (TMPP), tetrabromobisphenol A (TBBPA), tri-n-butyl phosphate (TNBP), tri(2-butoxyethyl) phosphate (TBOEP), tris(1-chloro-2-propyl) phosphate (TCIPP), 2-ethylhexyl diphenyl phosphate (EHDPP). ToxCast results confirmed in vivo based categorization for several FRs and identified potential molecular targets. For the nine Cat I FRs, we identified several molecular targets, health outcomes and some potential AOPs. However, the complete toxicity pathways leading from molecular targets to adverse health outcomes are still unknown, with the exception of TBBPA-induced neurotoxicity.ConclusionsThe approach presented in this study was particularly useful for the categorization of a large group of replacement FRs with relatively low data availability. We highlight priority compounds that critically need more toxicological studies or FRs for which regulatory measures could be envisaged. Our research also suggests that high toxicity indicated by ToxCast is particularly relevant for predicting higher hazard in vivo. Finally, we indicate several gaps and directions for future research, such as molecular targets that could be tested in vitro and health outcomes for cohort studies.

Návaznosti

EF16_013/0001761, projekt VaV

Název: RECETOX RI

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

733032, interní kód MU

Název: European Human Biomonitoring Initiative (Akronym: HBM4EU)

Investor: Evropská unie, European Human Biomonitoring Initiative, Health, demographic change and wellbeing (Societal Challenges)

Citovat

BAJARD ÉP.ESNER, Lola Murielle, Lisa Emily MELYMUK a Luděk BLÁHA. Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways. Environmental Sciences Europe. HEIDELBERG, GERMANY: Springer-Verlag, GmbH, Environmental Sciences Europe, 2019, roč. 31, February, s. 1-19. ISSN 2190-4715. Dostupné z: https://dx.doi.org/10.1186/s12302-019-0195-z.

@article{1548905,
   author = {Bajard ép.Esner, Lola Murielle and Melymuk, Lisa Emily and Bláha, Luděk},
   article_location = {HEIDELBERG, GERMANY},
   article_number = {February},
   doi = {http://dx.doi.org/10.1186/s12302-019-0195-z},
   keywords = {Flame retardants; ToxCast; AOP; Prioritization; Hazard; Mechanisms of toxicity},
   language = {eng},
   issn = {2190-4715},
   journal = {Environmental Sciences Europe},
   title = {Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways},
   url = {https://enveurope.springeropen.com/articles/10.1186/s12302-019-0195-z},
   volume = {31},
   year = {2019}
}

TY  - JOUR
ID  - 1548905
AU  - Bajard ép.Esner, Lola Murielle - Melymuk, Lisa Emily - Bláha, Luděk
PY  - 2019
TI  - Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways
JF  - Environmental Sciences Europe
VL  - 31
IS  - February
SP  - 1-19
EP  - 1-19
PB  - Springer-Verlag, GmbH, Environmental Sciences Europe
SN  - 21904715
KW  - Flame retardants
KW  - ToxCast
KW  - AOP
KW  - Prioritization
KW  - Hazard
KW  - Mechanisms of toxicity
UR  - https://enveurope.springeropen.com/articles/10.1186/s12302-019-0195-z
L2  - https://enveurope.springeropen.com/articles/10.1186/s12302-019-0195-z
N2  - BackgroundFlame retardants (FRs) are used in most consumer products and textiles to comply with current flammability standards. After the restriction of polybrominated diphenyl ethers, a large number of chemically diverse replacement FRs are increasingly used, but the risk they represent is not yet properly evaluated and their toxicity pathways are still poorly understood.ApproachWe collected in vivo toxicological information on 62 (including 52 non-regulated) FRs and established five prioritization categories (Cat I to V) based on data availability and toxicological concern. We then considered available in vitro toxicological data from ToxCast, as a complement to in vivo information. By combining these information sources, we then explored relevant toxicity mechanisms for nine selected FRs (Cat I) using the AOP (Adverse Outcome Pathway) framework.ResultsFor 20 FRs (Cat V), toxicological data on mammals were absent. Data available were scarce for another 22 FRs, of which 14 FRs (Cat II) may be of toxicological concern. We found substantial information for only ten replacement FRs, of which nine (Cat I) present some toxicological concern: tris-2-chloroethyl phosphate (TCEP), tris(1,3-dichloropropyl)phosphate (TDCIPP), triphenyl phosphate (TPhP), tricresyl phosphate (TMPP), tetrabromobisphenol A (TBBPA), tri-n-butyl phosphate (TNBP), tri(2-butoxyethyl) phosphate (TBOEP), tris(1-chloro-2-propyl) phosphate (TCIPP), 2-ethylhexyl diphenyl phosphate (EHDPP). ToxCast results confirmed in vivo based categorization for several FRs and identified potential molecular targets. For the nine Cat I FRs, we identified several molecular targets, health outcomes and some potential AOPs. However, the complete toxicity pathways leading from molecular targets to adverse health outcomes are still unknown, with the exception of TBBPA-induced neurotoxicity.ConclusionsThe approach presented in this study was particularly useful for the categorization of a large group of replacement FRs with relatively low data availability. We highlight priority compounds that critically need more toxicological studies or FRs for which regulatory measures could be envisaged. Our research also suggests that high toxicity indicated by ToxCast is particularly relevant for predicting higher hazard in vivo. Finally, we indicate several gaps and directions for future research, such as molecular targets that could be tested in vitro and health outcomes for cohort studies.
ER  -

BAJARD ÉP.ESNER, Lola Murielle, Lisa Emily MELYMUK a Luděk BLÁHA. Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways. \textit{Environmental Sciences Europe}. HEIDELBERG, GERMANY: Springer-Verlag, GmbH, Environmental Sciences Europe, 2019, roč.~31, February, s.~1-19. ISSN~2190-4715. Dostupné z: https://dx.doi.org/10.1186/s12302-019-0195-z.

Podrobný výpis o publikaci