Simulation of the biliary metal stent recanalisation using
endoluminal irreversible electroporation on porcine liver - in
vivo experiment

a 2019

Simulation of the biliary metal stent recanalisation using endoluminal irreversible electroporation on porcine liver - in vivo experiment

ROHAN, Tomáš; Tomáš ANDRAŠINA; Peter MATKULČÍK; Tomáš JŮZA; Jan ZAVADIL et al.

Základní údaje

Originální název

Simulation of the biliary metal stent recanalisation using endoluminal irreversible electroporation on porcine liver - in vivo experiment

Autoři

ROHAN, Tomáš; Tomáš ANDRAŠINA; Peter MATKULČÍK; Tomáš JŮZA; Jan ZAVADIL; Iva SVOBODOVÁ; Dalibor ČERVINKA a Vlastimil VÁLEK

Vydání

CIRSE 2019, 2019

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/19:00110835

Organizační jednotka

Lékařská fakulta

ISSN

DOI

https://doi.org/10.1007/s00270-019-02282-x

Klíčová slova anglicky

biliary intervention; stent recanalisation; irreversible electroporation

Štítky

rivok

Příznaky

Mezinárodní význam

Změněno: 21. 4. 2020 11:08, Mgr. Tereza Miškechová

Anotace

V originále

Purpose: To demonstrate feasibility of endoluminal irreversible electroporation using tubular catheter in biliary metal stent for recanalisation. Material and methods: 25 simulations of metal stent obstruction on porcine liver in vivo were performed by liver lower edge incision and its insertion in the biliary metal stent. In 14 cases endoluminal irreversible electroporation with tubular catheter prototype were performed, others were set as controls. Three diferent scenarios of IRE were simulated (one, two or zero electrodes in contact with metal stent). Ninety 100 us pulses with 300,650,1000 and 1300 Volts were used in each scenario. Electrical parameters, macroscopical changes, side efects were monitored during the procedure. Early complications were evaluated by CT immediately and 72 hours after the procedure, followed by samples harvesting. Results: There were no complications detected during the procedure and on following CTs, enduluminal IRE was succesful in all cases. Signifcant diference in impedance was observed between all scenario settings (p=0,02, Mann-Whitey). Short circuit occured immediately in 1300 V in all scenarios, in both cases of 1000 V with one electrode in contact with stent and in case where both electrodes were in contact with stent. The highest observed safe voltage for IRE in metal stent was 850 V/cm. Histopathological analysis showed signs of tissue necrosis which were not present in control samples. Conclusion: Endoluminal irreversible electroporation using tubular catheter seems safe and feasible method and has potential for non-thermal metal stent ingrowth treatment.

Návaznosti

MUNI/A/0996/2018, interní kód MU

Název: Infrared thermal imaging – neinvazivní zobrazovací metoda s využitím v klinickém prostředí (Akronym: IRT)

Investor: Masarykova univerzita, Infrared thermal imaging – neinvazivní zobrazovací metoda s využitím v klinickém prostředí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1574/2018, interní kód MU

Název: Onkologické radiologické intervence a jejich přínos v rámci komplexní onkologické léčby, srovnání s celorepublikovými výsledky onkologické léčby vybraných diagnóz II

Investor: Masarykova univerzita, Onkologické radiologické intervence a jejich přínos v rámci komplexní onkologické léčby, srovnání s celorepublikovými výsledky onkologické léčby vybraných diagnóz II, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

ROHAN, Tomáš; Tomáš ANDRAŠINA; Peter MATKULČÍK; Tomáš JŮZA; Jan ZAVADIL; Iva SVOBODOVÁ; Dalibor ČERVINKA a Vlastimil VÁLEK. Simulation of the biliary metal stent recanalisation using endoluminal irreversible electroporation on porcine liver - in vivo experiment. In CIRSE 2019. 2019. ISSN 1432-086X. Dostupné z: https://doi.org/10.1007/s00270-019-02282-x.

@proceedings{1564637,
   author = {Rohan, Tomáš and Andrašina, Tomáš and Matkulčík, Peter and Jůza, Tomáš and Zavadil, Jan and Svobodová, Iva and Červinka, Dalibor and Válek, Vlastimil},
   booktitle = {CIRSE 2019},
   doi = {https://doi.org/10.1007/s00270-019-02282-x},
   keywords = {biliary intervention; stent recanalisation; irreversible electroporation},
   language = {eng},
   title = {Simulation of the biliary metal stent recanalisation using endoluminal irreversible electroporation on porcine liver - in vivo experiment},
   url = {http://dx.doi.org/10.1007/s00270-019-02282-x},
   year = {2019}
}

TY  - CONF
ID  - 1564637
AU  - Rohan, Tomáš - Andrašina, Tomáš - Matkulčík, Peter - Jůza, Tomáš - Zavadil, Jan - Svobodová, Iva - Červinka, Dalibor - Válek, Vlastimil
PY  - 2019
TI  - Simulation of the biliary metal stent recanalisation using endoluminal irreversible electroporation on porcine liver - in vivo experiment
KW  - biliary intervention
KW  - stent recanalisation
KW  - irreversible electroporation
UR  - http://dx.doi.org/10.1007/s00270-019-02282-x
L2  - http://dx.doi.org/10.1007/s00270-019-02282-x
N2  - Purpose: To demonstrate feasibility of endoluminal irreversible electroporation using tubular catheter in biliary metal stent for recanalisation. Material and methods: 25 simulations of metal stent obstruction on porcine liver in vivo were performed by liver lower edge incision and its insertion in the biliary metal stent. In 14 cases endoluminal irreversible electroporation with tubular catheter prototype were performed, others were set as controls. Three diferent scenarios of IRE were simulated (one, two or zero electrodes in contact with metal stent). Ninety 100 us pulses with 300,650,1000 and 1300 Volts were used in each scenario. Electrical parameters, macroscopical changes, side efects were monitored during the procedure. Early complications were evaluated by CT immediately and 72 hours after the procedure, followed by samples harvesting. Results: There were no complications detected during the procedure and on following CTs, enduluminal IRE was succesful in all cases. Signifcant diference in impedance was observed between all scenario settings (p=0,02, Mann-Whitey). Short circuit occured immediately in 1300 V in all scenarios, in both cases of 1000 V with one electrode in contact with stent and in case where both electrodes were in contact with stent. The highest observed safe voltage for IRE in metal stent was 850 V/cm. Histopathological analysis showed signs of tissue necrosis which were not present in control samples. Conclusion: Endoluminal irreversible electroporation using tubular catheter seems safe and feasible method and has potential for non-thermal metal stent ingrowth treatment.
ER  -

ROHAN, Tomáš; Tomáš ANDRAŠINA; Peter MATKULČÍK; Tomáš JŮZA; Jan ZAVADIL; Iva SVOBODOVÁ; Dalibor ČERVINKA a Vlastimil VÁLEK. Simulation of the biliary metal stent recanalisation using endoluminal irreversible electroporation on porcine liver - in vivo experiment. In \textit{CIRSE 2019}. 2019. ISSN~1432-086X. Dostupné z: https://doi.org/10.1007/s00270-019-02282-x.

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