| VOLODKO, Nataliya, Taras GUTOR, Orest PETRONCHAK, Roman HULEY, Monika DÚCKA, Jan ŠMARDA, Lubor BORSIG, Petr BENEŠ a Lucia KNOPFOVÁ. Low infiltration of tumor-associated macrophages in high c-Myb-expressing breast tumors. Scientific reports. London: Nature Publishing Group, 2019, roč. 9, AUG 12 2019, s. 1-9. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-48051-1. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1600063,
author = {Volodko, Nataliya and Gutor, Taras and Petronchak, Orest and Huley, Roman and Dúcka, Monika and Šmarda, Jan and Borsig, Lubor and Beneš, Petr and Knopfová, Lucia},
article_location = {London},
article_number = {AUG 12 2019},
doi = {http://dx.doi.org/10.1038/s41598-019-48051-1},
keywords = {c-Myb; breast cancer; metastasis; survival},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Low infiltration of tumor-associated macrophages in high c-Myb-expressing breast tumors},
url = {https://www.nature.com/articles/s41598-019-48051-1},
volume = {9},
year = {2019}
}
TY - JOUR
ID - 1600063
AU - Volodko, Nataliya - Gutor, Taras - Petronchak, Orest - Huley, Roman - Dúcka, Monika - Šmarda, Jan - Borsig, Lubor - Beneš, Petr - Knopfová, Lucia
PY - 2019
TI - Low infiltration of tumor-associated macrophages in high c-Myb-expressing breast tumors
JF - Scientific reports
VL - 9
IS - AUG 12 2019
SP - 1-9
EP - 1-9
PB - Nature Publishing Group
SN - 20452322
KW - c-Myb
KW - breast cancer
KW - metastasis
KW - survival
UR - https://www.nature.com/articles/s41598-019-48051-1
L2 - https://www.nature.com/articles/s41598-019-48051-1
N2 - Tumor-associated macrophages (TAMs) are prominent components of tumor stroma that promotes tumorigenesis. Many soluble factors participate in the deleterious cross-talk between TAMs and transformed cells; however mechanisms how tumors orchestrate their production remain relatively unexplored. c-Myb is a transcription factor recently described as a negative regulator of a specific immune signature involved in breast cancer (BC) metastasis. Here we studied whether c-Myb expression is associated with an increased presence of TAMs in human breast tumors. Tumors with high frequency of c-Myb-positive cells have lower density of CD68-positive macrophages. The negative association is reflected by inverse correlation between MYB and CD68/CD163 markers at the mRNA levels in evaluated cohorts of BC patients from public databases, which was found also within the molecular subtypes. In addition, we identified potential MYB-regulated TAMs recruiting factors that in combination with MYB and CD163 provided a valuable clinical multigene predictor for BC relapse. We propose that identified transcription program running in tumor cells with high MYB expression and preventing macrophage accumulation may open new venues towards TAMs targeting and BC therapy.
ER -
VOLODKO, Nataliya, Taras GUTOR, Orest PETRONCHAK, Roman HULEY, Monika DÚCKA, Jan ŠMARDA, Lubor BORSIG, Petr BENEŠ a Lucia KNOPFOVÁ. Low infiltration of tumor-associated macrophages in high c-Myb-expressing breast tumors. \textit{Scientific reports}. London: Nature Publishing Group, 2019, roč.~9, AUG 12 2019, s.~1-9. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-48051-1.
|
