Serotonin transporter gene (SLC6A4) variability in patients
with recurrent aphthous stomatitis

J 2020

Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

SLEZÁKOVÁ, Simona; Petra BOŘILOVÁ LINHARTOVÁ; Jirina BARTOVA; Jitka PETANOVA; Pavel KUKLÍNEK et al.

Základní údaje

Originální název

Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

Autoři

SLEZÁKOVÁ, Simona; Petra BOŘILOVÁ LINHARTOVÁ; Jirina BARTOVA; Jitka PETANOVA; Pavel KUKLÍNEK; Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ

Vydání

Archives of Oral Biology, Oxford, Pergamon-Elsevier, 2020, 0003-9969

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.635

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/20:00115613

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Serotonin transporter gene; SLC6A4; Recurrent aphthous stomatitis; Polymorphism

Štítky

14110114, 14110130, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 1. 2021 18:27, doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA

Anotace

V originále

Objective: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Design: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. Results: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). Conclusions: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.

Návaznosti

MUNI/A/1546/2018, interní kód MU

Název: Etiopatogeneze, diagnostika a léčba vybraných onemocnění dutiny ústní a jejich souvislost s celkovým zdravotním stavem

Investor: Masarykova univerzita, Etiopatogeneze, diagnostika a léčba vybraných onemocnění dutiny ústní a jejich souvislost s celkovým zdravotním stavem, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

ROZV/23/LF1/2019, interní kód MU

Název: Studium genetické predispozice hostitele a jeho mikrobiomu ve vztahu k chorobám dutiny ústní na jícnu

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Studium genetické predispozice hostitele a jeho mikrobiomu ve vztahu k chorobám dutiny ústní na jícnu, Interní rozvojové projekty

Citovat

SLEZÁKOVÁ, Simona; Petra BOŘILOVÁ LINHARTOVÁ; Jirina BARTOVA; Jitka PETANOVA; Pavel KUKLÍNEK; Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ. Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. Archives of Oral Biology. Oxford: Pergamon-Elsevier, 2020, roč. 110, FEB 2020, s. 1-6. ISSN 0003-9969. Dostupné z: https://doi.org/10.1016/j.archoralbio.2019.104628.

@article{1653758,
   author = {Slezáková, Simona and Bořilová Linhartová, Petra and Bartova, Jirina and Petanova, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Izakovičová Hollá, Lydie},
   article_location = {Oxford},
   article_number = {FEB 2020},
   doi = {https://doi.org/10.1016/j.archoralbio.2019.104628},
   keywords = {Serotonin transporter gene; SLC6A4; Recurrent aphthous stomatitis; Polymorphism},
   language = {eng},
   issn = {0003-9969},
   journal = {Archives of Oral Biology},
   title = {Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis},
   url = {https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub},
   volume = {110},
   year = {2020}
}

TY  - JOUR
ID  - 1653758
AU  - Slezáková, Simona - Bořilová Linhartová, Petra - Bartova, Jirina - Petanova, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Izakovičová Hollá, Lydie
PY  - 2020
TI  - Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis
JF  - Archives of Oral Biology
VL  - 110
IS  - FEB 2020
SP  - 1-6
EP  - 1-6
PB  - Pergamon-Elsevier
SN  - 00039969
KW  - Serotonin transporter gene
KW  - SLC6A4
KW  - Recurrent aphthous stomatitis
KW  - Polymorphism
UR  - https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub
N2  - Objective: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Design: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. Results: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). Conclusions: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.
ER  -

SLEZÁKOVÁ, Simona; Petra BOŘILOVÁ LINHARTOVÁ; Jirina BARTOVA; Jitka PETANOVA; Pavel KUKLÍNEK; Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ. Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. \textit{Archives of Oral Biology}. Oxford: Pergamon-Elsevier, 2020, roč.~110, FEB 2020, s.~1-6. ISSN~0003-9969. Dostupné z: https://doi.org/10.1016/j.archoralbio.2019.104628.

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