| PAŘENICA, Jiří, Petr KALA, Alexandre MEBAZAA, Simona LITTNEROVÁ, Klára BENEŠOVÁ, Josef TOMANDL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jiří JARKOVSKÝ, Jindřich ŠPINAR, Marie TOMANDLOVÁ, Milan DASTYCH, Can INCE, Kateřina HELÁNOVÁ, Martin TESÁK, Martin HELÁN, Petr LOKAJ a Matthieu LEGRAND. Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury. CARDIORENAL MEDICINE. BASEL: KARGER, 2020, roč. 10, č. 2, s. 85-96. ISSN 1664-3828. Dostupné z: https://dx.doi.org/10.1159/000503718. |
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@article{1662576,
author = {Pařenica, Jiří and Kala, Petr and Mebazaa, Alexandre and Littnerová, Simona and Benešová, Klára and Tomandl, Josef and Pávková Goldbergová, Monika and Jarkovský, Jiří and Špinar, Jindřich and Tomandlová, Marie and Dastych, Milan and Ince, Can and Helánová, Kateřina and Tesák, Martin and Helán, Martin and Lokaj, Petr and Legrand, Matthieu},
article_location = {BASEL},
article_number = {2},
doi = {http://dx.doi.org/10.1159/000503718},
keywords = {Acute kidney injury; Nitric oxide; Myocardial infarction; Oxidative stress; Cardio renal},
language = {eng},
issn = {1664-3828},
journal = {CARDIORENAL MEDICINE},
title = {Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury},
url = {https://www.karger.com/Article/FullText/503718},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1662576
AU - Pařenica, Jiří - Kala, Petr - Mebazaa, Alexandre - Littnerová, Simona - Benešová, Klára - Tomandl, Josef - Pávková Goldbergová, Monika - Jarkovský, Jiří - Špinar, Jindřich - Tomandlová, Marie - Dastych, Milan - Ince, Can - Helánová, Kateřina - Tesák, Martin - Helán, Martin - Lokaj, Petr - Legrand, Matthieu
PY - 2020
TI - Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury
JF - CARDIORENAL MEDICINE
VL - 10
IS - 2
SP - 85-96
EP - 85-96
PB - KARGER
SN - 16643828
KW - Acute kidney injury
KW - Nitric oxide
KW - Myocardial infarction
KW - Oxidative stress
KW - Cardio renal
UR - https://www.karger.com/Article/FullText/503718
L2 - https://www.karger.com/Article/FullText/503718
N2 - Background/Aims: The pathophysiology of acute kidney injury (AKI) in ST-elevation myocardial infarction (STEMI) patients remains poorly explored. The involvement of the nitric oxide (NO) pathway has been demonstrated in experimental ischemic AKI. The aim of this study was to assess the predictive value of circulating biomarkers of the NO pathway for AKI in STEMI patients. Methods: Four hundred and twenty-seven STEMI patients treated with primary percutaneous coronary intervention were included. The primary end point was AKI. Biomarkers of the NO pathway (plasma superoxide dismutase [SOD], uric acid, nitrite/nitrate [NOx], neopterin) as well as cardiac biomarkers (B-type natriuretic peptide [BNP] and troponin) were sampled 12 h after admission. The predictive value of circulating biomarkers was evaluated in addition to the multivariate clinical model. Results: AKI developed in 8.9% of patients. The 3-month mortality was significantly higher in patients with AKI (34.2 vs. 4.1%; p < 0.001). SOD, uric acid, NOx, neopterin, BNP and troponin were significantly associated with the development of AKI (area under curve [AUC]-receiver operating curve [ROC] ranging between 0.70 and 0.81). In multivariate analysis cardiogenic shock, neopterin, NOx and troponin were independent predictors of AKI. AUC-ROC of the association of multibiomarkers and clinical model was 0.90 and outperformed the predictive value of the clinical model alone. OR of NOx >= 45 mu mol/L was 8.0 (95% CI 3.1-20.6) for AKI. Conclusion: Biomarkers of the NO pathway are associated with the development of AKI in STEMI patients. These results provide insights into the pathophysiology of AKI and may serve at developing preventing strategies for AKI targeting this pathway.
ER -
PAŘENICA, Jiří, Petr KALA, Alexandre MEBAZAA, Simona LITTNEROVÁ, Klára BENEŠOVÁ, Josef TOMANDL, Monika PÁVKOVÁ GOLDBERGOVÁ, Jiří JARKOVSKÝ, Jindřich ŠPINAR, Marie TOMANDLOVÁ, Milan DASTYCH, Can INCE, Kateřina HELÁNOVÁ, Martin TESÁK, Martin HELÁN, Petr LOKAJ a Matthieu LEGRAND. Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury. \textit{CARDIORENAL MEDICINE}. BASEL: KARGER, 2020, roč.~10, č.~2, s.~85-96. ISSN~1664-3828. Dostupné z: https://dx.doi.org/10.1159/000503718.
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