Platelet-rich plasma, platelet-rich fibrin, and enamel matrix
derivative for oral mucosal wound healing

J 2020

Platelet-rich plasma, platelet-rich fibrin, and enamel matrix derivative for oral mucosal wound healing

VOKURKA, Jan; Filip HROMČÍK; Martin FALDYNA; Eduard GÖPFERT; Monika VICENOVÁ et al.

Základní údaje

Originální název

Platelet-rich plasma, platelet-rich fibrin, and enamel matrix derivative for oral mucosal wound healing

Autoři

VOKURKA, Jan; Filip HROMČÍK ; Martin FALDYNA; Eduard GÖPFERT; Monika VICENOVÁ; Lucie POŽÁROVÁ a Lydie IZAKOVIČOVÁ HOLLÁ

Vydání

Polish Journal of Veterinary Sciences, Olsztyn, Polish Academy of Sciences Committee of Veterinary Sciences, University of Warmia and Mazury in Olsztyn, 2020, 1505-1773

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Norsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

záznam na stráce vydavatele

Impakt faktor

Impact factor: 0.821

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/20:00115955

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

plasma bohatá na trombocyty; fibrin bohatý na trombocyty; destičkové koncentráty; hojení ran; orální sliznice; derivát sklovinné matrix

Klíčová slova anglicky

platelet-rich plasma; platelet-rich fibrin; wound healing; dental enamel proteins; artificial membranes

Štítky

14110130, EMD, fibrin bohatý na trombocyty, hojení, plazma bohatá na trombocyty, PRP, PřF, rivok, sliznice

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 8. 2020 08:20, Mgr. Tereza Miškechová

Anotace

V originále

Different approaches to enhance healing of hard or soft tissues include the use of cytokines and growth factors to modify cellular behaviour. Numerous growth factors are found in autologous blood concentrates – platelet rich plasma (PRP) and platelet rich fibrin (PRF). Enamel matrix derivative (EMD) may improve tissue healing via amelogenins. Bilayered collagen matrix (CM) is used for soft tissue augmentation. The aim of the present study was to assess potential benefits of PRP, PRF and EMD in combination with bilayered collagen matrix or CM alone in treatment of oral mucosal defects in rabbits. Twenty-seven New Zealand white rabbits were included in this randomized controlled trial. Artificial oral mucosal defects were treated with one of these five approaches: PRP+CM, PRF+CM, EMD+CM, CM alone, or left untreated as a negative control (CO). The animals were euthanized 1 day, 7 days, or 28 days after surgery and necropsies were harvested. Histological and molecular biological analyses were performed. All defects were healed by day 28. No differences between PRP+CM, PRF+CM, CM alone and CO groups were recorded at any time point. Slower angiogenesis and a higher presence of inflammatory infiltrate were observed in the EMD+CM group 28 days after surgery. Molecular biological analyses did not reveal any statistically significant changes. In conclusion, no improvement in mucosal healing of wounds covered with a collagen membrane and PRP, PRF, or EMD was observed, compared with CM alone or untreated controls.

Návaznosti

MUNI/A/1428/2019, interní kód MU

Název: Onemocnění dutiny ústní – etiopatogeneze, diagnostika a léčba

Investor: Masarykova univerzita, Onemocnění dutiny ústní – etiopatogeneze, diagnostika a léčba, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Přiložené soubory

Vokurka_-_PRP_PRF_EMD_for_soft_tissue_healing.pdf

Citovat

VOKURKA, Jan; Filip HROMČÍK; Martin FALDYNA; Eduard GÖPFERT; Monika VICENOVÁ; Lucie POŽÁROVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. Platelet-rich plasma, platelet-rich fibrin, and enamel matrix derivative for oral mucosal wound healing. Polish Journal of Veterinary Sciences. Olsztyn: Polish Academy of Sciences Committee of Veterinary Sciences, University of Warmia and Mazury in Olsztyn, 2020, roč. 23, č. 2, s. 169-176. ISSN 1505-1773. Dostupné z: https://doi.org/10.24425/pjvs.2020.132762.

@article{1669896,
   author = {Vokurka, Jan and Hromčík, Filip and Faldyna, Martin and Göpfert, Eduard and Vicenová, Monika and Požárová, Lucie and Izakovičová Hollá, Lydie},
   article_location = {Olsztyn},
   article_number = {2},
   doi = {https://doi.org/10.24425/pjvs.2020.132762},
   keywords = {platelet-rich plasma; platelet-rich fibrin; wound healing; dental enamel proteins; artificial membranes},
   language = {eng},
   issn = {1505-1773},
   journal = {Polish Journal of Veterinary Sciences},
   title = {Platelet-rich plasma, platelet-rich fibrin, and enamel matrix derivative for oral mucosal wound healing},
   url = {http://journals.pan.pl/dlibra/publication/132762/edition/116002/content},
   volume = {23},
   year = {2020}
}

TY  - JOUR
ID  - 1669896
AU  - Vokurka, Jan - Hromčík, Filip - Faldyna, Martin - Göpfert, Eduard - Vicenová, Monika - Požárová, Lucie - Izakovičová Hollá, Lydie
PY  - 2020
TI  - Platelet-rich plasma, platelet-rich fibrin, and enamel matrix derivative for oral mucosal wound healing
JF  - Polish Journal of Veterinary Sciences
VL  - 23
IS  - 2
SP  - 169-176
EP  - 169-176
PB  - Polish Academy of Sciences Committee of Veterinary Sciences, University of Warmia and Mazury in Olsztyn
SN  - 15051773
KW  - platelet-rich plasma
KW  - platelet-rich fibrin
KW  - wound healing
KW  - dental enamel proteins
KW  - artificial membranes
UR  - http://journals.pan.pl/dlibra/publication/132762/edition/116002/content
L2  - http://journals.pan.pl/dlibra/publication/132762/edition/116002/content
N2  - Different approaches to enhance healing of hard or soft tissues include the use of cytokines and growth factors to modify cellular behaviour. Numerous growth factors are found in autologous blood concentrates – platelet rich plasma (PRP) and platelet rich fibrin (PRF). Enamel matrix derivative (EMD) may improve tissue healing via amelogenins. Bilayered collagen matrix (CM) is used for soft tissue augmentation. The aim of the present study was to assess potential benefits of PRP, PRF and EMD in combination with bilayered collagen matrix or CM alone in treatment of oral mucosal defects in rabbits. Twenty-seven New Zealand white rabbits were included in this randomized controlled trial. Artificial oral mucosal defects were treated with one of these five approaches: PRP+CM, PRF+CM, EMD+CM, CM alone, or left untreated as a negative control (CO). The animals were euthanized 1 day, 7 days, or 28 days after surgery and necropsies were harvested. Histological and molecular biological analyses were performed. All defects were healed by day 28. No differences between PRP+CM, PRF+CM, CM alone and CO groups were recorded at any time point. Slower angiogenesis and a higher presence of inflammatory infiltrate were observed in the EMD+CM group 28 days after surgery. Molecular biological analyses did not reveal any statistically significant changes. In conclusion, no improvement in mucosal healing of wounds covered with a collagen membrane and PRP, PRF, or EMD was observed, compared with CM alone or untreated controls.
ER  -

VOKURKA, Jan; Filip HROMČÍK; Martin FALDYNA; Eduard GÖPFERT; Monika VICENOVÁ; Lucie POŽÁROVÁ a Lydie IZAKOVIČOVÁ HOLLÁ. Platelet-rich plasma, platelet-rich fibrin, and enamel matrix derivative for oral mucosal wound healing. \textit{Polish Journal of Veterinary Sciences}. Olsztyn: Polish Academy of Sciences Committee of Veterinary Sciences, University of Warmia and Mazury in Olsztyn, 2020, roč.~23, č.~2, s.~169-176. ISSN~1505-1773. Dostupné z: https://doi.org/10.24425/pjvs.2020.132762.

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