TREML, Jakub, Veronika LELÁKOVÁ, Karel ŠMEJKAL, T PAULICKOVA, S LABUDA, S GRANICA, J HAVLIK, Dagmar JANKOVSKÁ, Tereza PADRTOVÁ a J HOSEK. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. Biomolecules. BASEL: MDPI, 2019, roč. 9, č. 9, 16 s. ISSN 0066-605X. doi:10.3390/biom9090468.
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Základní údaje
Originální název Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
Autoři TREML, Jakub, Veronika LELÁKOVÁ, Karel ŠMEJKAL, T PAULICKOVA, S LABUDA, S GRANICA, J HAVLIK, Dagmar JANKOVSKÁ, Tereza PADRTOVÁ a J HOSEK.
Vydání Biomolecules, BASEL, MDPI, 2019, 0066-605X.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30104 Pharmacology and pharmacy
Utajení není předmětem státního či obchodního tajemství
Organizační jednotka Farmaceutická fakulta
Doi http://dx.doi.org/10.3390/biom9090468
UT WoS 000489102800080
Klíčová slova anglicky stilbenoid; antioxidant; pro-oxidant; pyocyanin; Nrf2; macrophages
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: PharmDr. Jitka Michlíčková, učo 151288. Změněno: 17. 2. 2021 13:44.
Anotace
The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo.
VytisknoutZobrazeno: 18. 5. 2021 15:41