Erythropoetins in Therapy from the Point of View of a Medicinal Chemist

FARSA, Oldřich a Peter ZUBÁČ. Erythropoetins in Therapy from the Point of View of a Medicinal Chemist. CHEMICKÉ LISTY. Praha: Česká společnost chemická, 2019, roč. 113, č. 9, s. 540-544. ISSN 0009-2770.

Základní údaje

Originální název

Erythropoetins in Therapy from the Point of View of a Medicinal Chemist

Název anglicky

Erythropoetins in Therapy from the Point of View of a Medicinal Chemist

Autoři

FARSA, Oldřich ORCID a Peter ZUBÁČ

Vydání

CHEMICKÉ LISTY, Praha, Česká společnost chemická, 2019, 0009-2770

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Další údaje

Jazyk

čeština

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Stránky časopisu Chemické listy

Impakt faktor

Impact factor: 0.390

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/19:00120954

Organizační jednotka

Farmaceutická fakulta

UT WoS

000485833300004

Klíčová slova anglicky

biological therapeutics; haematopoietic factors; erythropoietin

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Hematopoietic growth factors are cytokines which stimulate growth of hematopoietic pluripotent stem cells and their differentiation and maturation into fully functional blood cells, either erythrocytes or various types of white blood cells. Erythropoietin is a glycosylated peptide hormone which stimulates production of red blood cells. It is used for treatment of anaemia caused by a chronic kidney failure. For therapeutic purposes, it is produced by recombinant technologies predominantly using modified mammalian cells. This procedure leads, however, to peptides of the same sequence of 165 amino acids but with different glycosylation patterns. These different mixtures of erythropoietin glycoforms have been designated with different INN names epoetin alfa - omega. Peginesatid (Omontys (R)) is a synthetic erythropoietin receptor agonist, the structure of which does not match that of erythropoietin. It is a pegylated covalent dimer of two identical peptide chains. It has been abandoned due to an increased mortality from cardiovascular reasons and due to dangerous allergies.

Anglicky

Hematopoietic growth factors are cytokines which stimulate growth of hematopoietic pluripotent stem cells and their differentiation and maturation into fully functional blood cells, either erythrocytes or various types of white blood cells. Erythropoietin is a glycosylated peptide hormone which stimulates production of red blood cells. It is used for treatment of anaemia caused by a chronic kidney failure. For therapeutic purposes, it is produced by recombinant technologies predominantly using modified mammalian cells. This procedure leads, however, to peptides of the same sequence of 165 amino acids but with different glycosylation patterns. These different mixtures of erythropoietin glycoforms have been designated with different INN names epoetin alfa - omega. Peginesatid (Omontys (R)) is a synthetic erythropoietin receptor agonist, the structure of which does not match that of erythropoietin. It is a pegylated covalent dimer of two identical peptide chains. It has been abandoned due to an increased mortality from cardiovascular reasons and due to dangerous allergies.