Erythropoetins in Therapy from the Point of View of a Medicinal Chemist

FARSA, Oldřich a Peter ZUBÁČ. Erythropoetins in Therapy from the Point of View of a Medicinal Chemist. CHEMICKÉ LISTY. Praha: Česká společnost chemická, 2019, roč. 113, č. 9, s. 540-544. ISSN 0009-2770.

Základní údaje

• Originální název: Erythropoetins in Therapy from the Point of View of a Medicinal Chemist
• Název anglicky: Erythropoetins in Therapy from the Point of View of a Medicinal Chemist
• Autoři: FARSA, Oldřich (203 Česká republika, garant, domácí) a Peter ZUBÁČ (703 Slovensko, domácí).
• Vydání: CHEMICKÉ LISTY, Praha, Česká společnost chemická, 2019, 0009-2770.

Další údaje

• Originální jazyk: čeština
• Typ výsledku: Článek v odborném periodiku
• Obor: 30104 Pharmacology and pharmacy
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• WWW: Stránky časopisu Chemické listy
• Impakt faktor: Impact factor: 0.390
• Kód RIV: RIV/00216224:14160/19:00120954
• Organizační jednotka: Farmaceutická fakulta
• UT WoS: 000485833300004
• Klíčová slova anglicky: biological therapeutics; haematopoietic factors; erythropoietin
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

Hematopoietic growth factors are cytokines which stimulate growth of hematopoietic pluripotent stem cells and their differentiation and maturation into fully functional blood cells, either erythrocytes or various types of white blood cells. Erythropoietin is a glycosylated peptide hormone which stimulates production of red blood cells. It is used for treatment of anaemia caused by a chronic kidney failure. For therapeutic purposes, it is produced by recombinant technologies predominantly using modified mammalian cells. This procedure leads, however, to peptides of the same sequence of 165 amino acids but with different glycosylation patterns. These different mixtures of erythropoietin glycoforms have been designated with different INN names epoetin alfa - omega. Peginesatid (Omontys (R)) is a synthetic erythropoietin receptor agonist, the structure of which does not match that of erythropoietin. It is a pegylated covalent dimer of two identical peptide chains. It has been abandoned due to an increased mortality from cardiovascular reasons and due to dangerous allergies.

Anotace anglicky

Hematopoietic growth factors are cytokines which stimulate growth of hematopoietic pluripotent stem cells and their differentiation and maturation into fully functional blood cells, either erythrocytes or various types of white blood cells. Erythropoietin is a glycosylated peptide hormone which stimulates production of red blood cells. It is used for treatment of anaemia caused by a chronic kidney failure. For therapeutic purposes, it is produced by recombinant technologies predominantly using modified mammalian cells. This procedure leads, however, to peptides of the same sequence of 165 amino acids but with different glycosylation patterns. These different mixtures of erythropoietin glycoforms have been designated with different INN names epoetin alfa - omega. Peginesatid (Omontys (R)) is a synthetic erythropoietin receptor agonist, the structure of which does not match that of erythropoietin. It is a pegylated covalent dimer of two identical peptide chains. It has been abandoned due to an increased mortality from cardiovascular reasons and due to dangerous allergies.