Antimicrobial and enzyme inhibitory activities of the
constituents of Plectranthus madagascariensis (Pers.) Benth

J 2014

Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth

KUBÍNOVÁ, Renata; R. PORIZKOVA; Alice SYCHROVÁ; Oldřich FARSA; Zuzana HANÁKOVÁ et al.

Základní údaje

Originální název

Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth

Autoři

KUBÍNOVÁ, Renata; R. PORIZKOVA; Alice SYCHROVÁ; Oldřich FARSA ; Zuzana HANÁKOVÁ; A. BACINSKA; Alois ČÍŽEK a Marie VALENTOVÁ

Vydání

Journal of Enzyme Inhibition and Medicinal Chemistry, UK, Taylor & Francis, 2014, 1475-6366

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.332

Označené pro přenos do RIV

Organizační jednotka

Farmaceutická fakulta

DOI

https://doi.org/10.3109/14756366.2013.848204

UT WoS

000342056900020

Klíčová slova anglicky

alpha-glucosidase; antibacterial activity; cholinesterase; diterpenoids; rosmarinic acid

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 7. 2021 08:31, Mgr. Hana Hurtová

Anotace

V originále

Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7 beta, 6 beta-dihydroxyroyleanone (2), 7 beta-acetoxy-6 beta-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and alpha-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alpha-glucosidase with IC50 values from 33 to 275 mu M. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.

Citovat

KUBÍNOVÁ, Renata; R. PORIZKOVA; Alice SYCHROVÁ; Oldřich FARSA; Zuzana HANÁKOVÁ; A. BACINSKA; Alois ČÍŽEK a Marie VALENTOVÁ. Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth. Journal of Enzyme Inhibition and Medicinal Chemistry. UK: Taylor & Francis, 2014, roč. 29, č. 5, s. 749-752. ISSN 1475-6366. Dostupné z: https://doi.org/10.3109/14756366.2013.848204.

@article{1781680,
   author = {Kubínová, Renata and Porizkova, R. and Sychrová, Alice and Farsa, Oldřich and Hanáková, Zuzana and Bacinska, A. and Čížek, Alois and Valentová, Marie},
   article_location = {UK},
   article_number = {5},
   doi = {https://doi.org/10.3109/14756366.2013.848204},
   keywords = {alpha-glucosidase; antibacterial activity; cholinesterase; diterpenoids; rosmarinic acid},
   language = {eng},
   issn = {1475-6366},
   journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
   title = {Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth},
   url = {https://pubmed.ncbi.nlm.nih.gov/24506206/},
   volume = {29},
   year = {2014}
}

TY  - JOUR
ID  - 1781680
AU  - Kubínová, Renata - Porizkova, R. - Sychrová, Alice - Farsa, Oldřich - Hanáková, Zuzana - Bacinska, A. - Čížek, Alois - Valentová, Marie
PY  - 2014
TI  - Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
JF  - Journal of Enzyme Inhibition and Medicinal Chemistry
VL  - 29
IS  - 5
SP  - 749-752
EP  - 749-752
PB  - Taylor & Francis
SN  - 14756366
KW  - alpha-glucosidase
KW  - antibacterial activity
KW  - cholinesterase
KW  - diterpenoids
KW  - rosmarinic acid
UR  - https://pubmed.ncbi.nlm.nih.gov/24506206/
N2  - Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7 beta, 6 beta-dihydroxyroyleanone (2), 7 beta-acetoxy-6 beta-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and alpha-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alpha-glucosidase with IC50 values from 33 to 275 mu M. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
ER  -

KUBÍNOVÁ, Renata; R. PORIZKOVA; Alice SYCHROVÁ; Oldřich FARSA; Zuzana HANÁKOVÁ; A. BACINSKA; Alois ČÍŽEK a Marie VALENTOVÁ. Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth. \textit{Journal of Enzyme Inhibition and Medicinal Chemistry}. UK: Taylor \&{} Francis, 2014, roč.~29, č.~5, s.~749-752. ISSN~1475-6366. Dostupné z: https://doi.org/10.3109/14756366.2013.848204.

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