Synthetic Biomimetic Polymethacrylates: Promising Platform for
the Design of Anti-Cyanobacterial and Anti-Algal Agents

J 2021

Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents

MIKULA, Přemysl; Marie MLNAŘÍKOVÁ; Enrico T. NADRES; Haruko TAKAHASHI; Pavel BABICA et al.

Základní údaje

Originální název

Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents

Autoři

MIKULA, Přemysl; Marie MLNAŘÍKOVÁ; Enrico T. NADRES; Haruko TAKAHASHI; Pavel BABICA; Kenichi KURODA; Luděk BLÁHA a Iva SOVADINOVÁ

Vydání

Polymers, BASEL, MDPI, 2021, 2073-4360

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10404 Polymer science

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.967

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00122093

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

algae; antimicrobials; biomimetic polymers; cyanobacteria; polymethacrylates; water treatment

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 6. 2025 12:41, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Extensive, uncontrolled growth of algae and cyanobacteria is an environmental, public health, economic, and technical issue in managing natural and engineered water systems. Synthetic biomimetic polymers have been almost exclusively considered antimicrobial alternatives to conventional antibiotics to treat human bacterial infections. Very little is known about their applicability in an aquatic environment. Here, we introduce synthetic biomimetic polymethacrylates (SBPs) as a cost-effective and chemically facile, flexible platform for designing a new type of agent suitable for controlling and mitigating photosynthetic microorganisms. Since SBPs are cationic and membranolytic in heterotrophic bacteria, we hypothesized they could also interact with negatively charged cyanobacterial or algal cell walls and membranes. We demonstrated that SBPs inhibited the growth of aquatic photosynthetic organisms of concern, i.e., cyanobacteria (Microcystis aeruginosa and Synechococcus elongatus) and green algae (Chlamydomonas reinhardtii and Desmodesmus quadricauda), with 50% effective growth-inhibiting concentrations ranging between 95 nM and 6.5 mu M. Additionally, SBPs exhibited algicidal effects on C. reinhardtii and cyanocidal effects on picocyanobacterium S. elongatus and microcystin-producing cyanobacterium M. aeruginosa. SBP copolymers, particularly those with moderate hydrophobic content, induced more potent cyanostatic and cyanocidal effects than homopolymers. Thus, biomimetic polymers are a promising platform for the design of anti-cyanobacterial and anti-algal agents for water treatment.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

MIKULA, Přemysl; Marie MLNAŘÍKOVÁ; Enrico T. NADRES; Haruko TAKAHASHI; Pavel BABICA; Kenichi KURODA; Luděk BLÁHA a Iva SOVADINOVÁ. Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents. Polymers. BASEL: MDPI, 2021, roč. 13, č. 7, s. 1-16. ISSN 2073-4360. Dostupné z: https://doi.org/10.3390/polym13071025.

@article{1786146,
   author = {Mikula, Přemysl and Mlnaříková, Marie and Nadres, Enrico T. and Takahashi, Haruko and Babica, Pavel and Kuroda, Kenichi and Bláha, Luděk and Sovadinová, Iva},
   article_location = {BASEL},
   article_number = {7},
   doi = {https://doi.org/10.3390/polym13071025},
   keywords = {algae; antimicrobials; biomimetic polymers; cyanobacteria; polymethacrylates; water treatment},
   language = {eng},
   issn = {2073-4360},
   journal = {Polymers},
   title = {Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents},
   url = {https://www.mdpi.com/2073-4360/13/7/1025},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1786146
AU  - Mikula, Přemysl - Mlnaříková, Marie - Nadres, Enrico T. - Takahashi, Haruko - Babica, Pavel - Kuroda, Kenichi - Bláha, Luděk - Sovadinová, Iva
PY  - 2021
TI  - Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents
JF  - Polymers
VL  - 13
IS  - 7
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 20734360
KW  - algae
KW  - antimicrobials
KW  - biomimetic polymers
KW  - cyanobacteria
KW  - polymethacrylates
KW  - water treatment
UR  - https://www.mdpi.com/2073-4360/13/7/1025
N2  - Extensive, uncontrolled growth of algae and cyanobacteria is an environmental, public health, economic, and technical issue in managing natural and engineered water systems. Synthetic biomimetic polymers have been almost exclusively considered antimicrobial alternatives to conventional antibiotics to treat human bacterial infections. Very little is known about their applicability in an aquatic environment. Here, we introduce synthetic biomimetic polymethacrylates (SBPs) as a cost-effective and chemically facile, flexible platform for designing a new type of agent suitable for controlling and mitigating photosynthetic microorganisms. Since SBPs are cationic and membranolytic in heterotrophic bacteria, we hypothesized they could also interact with negatively charged cyanobacterial or algal cell walls and membranes. We demonstrated that SBPs inhibited the growth of aquatic photosynthetic organisms of concern, i.e., cyanobacteria (Microcystis aeruginosa and Synechococcus elongatus) and green algae (Chlamydomonas reinhardtii and Desmodesmus quadricauda), with 50% effective growth-inhibiting concentrations ranging between 95 nM and 6.5 mu M. Additionally, SBPs exhibited algicidal effects on C. reinhardtii and cyanocidal effects on picocyanobacterium S. elongatus and microcystin-producing cyanobacterium M. aeruginosa. SBP copolymers, particularly those with moderate hydrophobic content, induced more potent cyanostatic and cyanocidal effects than homopolymers. Thus, biomimetic polymers are a promising platform for the design of anti-cyanobacterial and anti-algal agents for water treatment.
ER  -

MIKULA, Přemysl; Marie MLNAŘÍKOVÁ; Enrico T. NADRES; Haruko TAKAHASHI; Pavel BABICA; Kenichi KURODA; Luděk BLÁHA a Iva SOVADINOVÁ. Synthetic Biomimetic Polymethacrylates: Promising Platform for the Design of Anti-Cyanobacterial and Anti-Algal Agents. \textit{Polymers}. BASEL: MDPI, 2021, roč.~13, č.~7, s.~1-16. ISSN~2073-4360. Dostupné z: https://doi.org/10.3390/polym13071025.

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