Flame Retardants-Mediated Interferon Signaling in the
Pathogenesis of Nonalcoholic Fatty Liver Disease

J 2021

Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease

NEGI, Chander Kant; Sabbir KHAN; Hubert DIRVEN; Lola Murielle BAJARD ÉP.ESNER; Luděk BLÁHA et al.

Základní údaje

Originální název

Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Autoři

NEGI, Chander Kant; Sabbir KHAN; Hubert DIRVEN; Lola Murielle BAJARD ÉP.ESNER a Luděk BLÁHA

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2021, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00122095

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

flame retardants; nonalcoholic fatty liver disease; metabolism-disrupting chemicals; cytokines; interferon; metabolic disruption

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 6. 2025 11:34, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Nonalcoholic fatty liver disease (NAFLD) is a growing concern worldwide, affecting 25% of the global population. NAFLD is a multifactorial disease with a broad spectrum of pathology includes steatosis, which gradually progresses to a more severe condition such as nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and eventually leads to hepatic cancer. Several risk factors, including exposure to environmental toxicants, are involved in the development and progression of NAFLD. Environmental factors may promote the development and progression of NAFLD by various biological alterations, including mitochondrial dysfunction, reactive oxygen species production, nuclear receptors dysregulation, and interference in inflammatory and immune-mediated signaling. Moreover, environmental contaminants can influence immune responses by impairing the immune system's components and, ultimately, disease susceptibility. Flame retardants (FRs) are anthropogenic chemicals or mixtures that are being used to inhibit or delay the spread of fire. FRs have been employed in several household and outdoor products; therefore, human exposure is unavoidable. In this review, we summarized the potential mechanisms of FRs-associated immune and inflammatory signaling and their possible contribution to the development and progression of NAFLD, with an emphasis on FRs-mediated interferon signaling. Knowledge gaps are identified, and emerging pharmacotherapeutic molecules targeting the immune and inflammatory signaling for NAFLD are also discussed.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

733032, interní kód MU

Název: European Human Biomonitoring Initiative (Akronym: HBM4EU)

Investor: Evropská unie, European Human Biomonitoring Initiative, Health, demographic change and wellbeing (Societal Challenges)

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

859891, interní kód MU

Název: Best chemical risk assessment professionals for maximum Ecosystem Services benefit (Akronym: PRORISK)

Investor: Evropská unie, Best chemical risk assessment professionals for maximum Ecosystem Services benefit, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Přiložené soubory

1786148.pdf

Citovat

NEGI, Chander Kant; Sabbir KHAN; Hubert DIRVEN; Lola Murielle BAJARD ÉP.ESNER a Luděk BLÁHA. Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2021, roč. 22, č. 8, s. 1-29. ISSN 1422-0067. Dostupné z: https://doi.org/10.3390/ijms22084282.

@article{1786148,
   author = {Negi, Chander Kant and Khan, Sabbir and Dirven, Hubert and Bajard ép.Esner, Lola Murielle and Bláha, Luděk},
   article_location = {Basel},
   article_number = {8},
   doi = {https://doi.org/10.3390/ijms22084282},
   keywords = {flame retardants; nonalcoholic fatty liver disease; metabolism-disrupting chemicals; cytokines; interferon; metabolic disruption},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease},
   url = {https://www.mdpi.com/1422-0067/22/8/4282},
   volume = {22},
   year = {2021}
}

TY  - JOUR
ID  - 1786148
AU  - Negi, Chander Kant - Khan, Sabbir - Dirven, Hubert - Bajard ép.Esner, Lola Murielle - Bláha, Luděk
PY  - 2021
TI  - Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease
JF  - International Journal of Molecular Sciences
VL  - 22
IS  - 8
SP  - 1-29
EP  - 1-29
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - flame retardants
KW  - nonalcoholic fatty liver disease
KW  - metabolism-disrupting chemicals
KW  - cytokines
KW  - interferon
KW  - metabolic disruption
UR  - https://www.mdpi.com/1422-0067/22/8/4282
N2  - Nonalcoholic fatty liver disease (NAFLD) is a growing concern worldwide, affecting 25% of the global population. NAFLD is a multifactorial disease with a broad spectrum of pathology includes steatosis, which gradually progresses to a more severe condition such as nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and eventually leads to hepatic cancer. Several risk factors, including exposure to environmental toxicants, are involved in the development and progression of NAFLD. Environmental factors may promote the development and progression of NAFLD by various biological alterations, including mitochondrial dysfunction, reactive oxygen species production, nuclear receptors dysregulation, and interference in inflammatory and immune-mediated signaling. Moreover, environmental contaminants can influence immune responses by impairing the immune system's components and, ultimately, disease susceptibility. Flame retardants (FRs) are anthropogenic chemicals or mixtures that are being used to inhibit or delay the spread of fire. FRs have been employed in several household and outdoor products; therefore, human exposure is unavoidable. In this review, we summarized the potential mechanisms of FRs-associated immune and inflammatory signaling and their possible contribution to the development and progression of NAFLD, with an emphasis on FRs-mediated interferon signaling. Knowledge gaps are identified, and emerging pharmacotherapeutic molecules targeting the immune and inflammatory signaling for NAFLD are also discussed.
ER  -

NEGI, Chander Kant; Sabbir KHAN; Hubert DIRVEN; Lola Murielle BAJARD ÉP.ESNER a Luděk BLÁHA. Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2021, roč.~22, č.~8, s.~1-29. ISSN~1422-0067. Dostupné z: https://doi.org/10.3390/ijms22084282.

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