2020
C-peptide affects glyoxalase 1 level in proximal tubular cells in vitro
KROČKA, Erik; David GALUŠKA; Katarína CHALÁSOVÁ; Lukáš PÁCAL; Kateřina KAŇKOVÁ et al.Základní údaje
Originální název
C-peptide affects glyoxalase 1 level in proximal tubular cells in vitro
Vydání
56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), 2020
Další údaje
Jazyk
angličtina
Typ výsledku
Konferenční abstrakt
Obor
30202 Endocrinology and metabolism
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 10.122
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/20:00120126
Organizační jednotka
Lékařská fakulta
ISSN
UT WoS
Klíčová slova anglicky
C-peptide; glyoxalase 1 level; proximal tubular cells; in vitro
Štítky
Změněno: 23. 8. 2021 13:01, Mgr. Tereza Miškechová
Anotace
V originále
Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease. Therapeutic strategy to prevent DKD progression involves compensation of diabetes and control of blood pressure, lipids and other metabolic parameters. However, even strict control does not have to be efficient enough. Glyoxalase system with enzyme glyoxalase I (GLO-1) is considered a protective pathway as it eliminates reactive aldehyde methylglyoxal that is involved in the development of DKD. C-peptide which has been long considered as an inert molecule, gained attention recently as it shows favourable effect on molecular and organ level in diabetes. It was shown to increase activity and expression of several antioxidants and it improved renal parameters in animal experiments. The aim of the in vitro experiment was to study the effect of C-peptide on GLO-1.
Návaznosti
| NV18-01-00046, projekt VaV |
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