Is centrifugal ultrafiltration a robust method for determining
encapsulation efficiency of pesticide nanoformulations?

J 2021

Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations?

LÓPEZ CABEZA, María del Rocío; Mélanie Marie KAH; Renato GRILLO; Zuzana BÍLKOVÁ; Jakub HOFMAN et al.

Základní údaje

Originální název

Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations?

Autoři

LÓPEZ CABEZA, María del Rocío; Mélanie Marie KAH; Renato GRILLO; Zuzana BÍLKOVÁ a Jakub HOFMAN

Vydání

Nanoscale, Cambridge, Royal Society of Chemistry, 2021, 2040-3364

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.307

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00119168

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Pesticides; nanoparticles; ultrafiltration

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 6. 2025 21:35, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Loading active ingredients on nanocarrier systems is becoming a common strategy for improving pesticide formulations. One of the most important properties of these nanoformulations is the proportion of pesticide associated with the nanocarriers (encapsulation efficiency, EE). EE is often determined by centrifugal ultrafiltration. However, the losses of active ingredient in the centrifugal ultrafiltration devices are typically not assessed, potentially leading to erroneous results. In this work, the losses of three pesticides (tebuconazole, terbuthylazine and chlorpyrifos) during centrifugal ultrafiltration have been systematically evaluated for nine different devices. Results suggest that centrifugal ultrafiltration is not suitable for determining the EE of compounds such as chlorpyrifos as 100% losses were observed on all the devices tested. Losses of tebuconazole and terbuthylazine were highly variable according to the type of membrane and the lowest losses were observed in the devices with hydrophilic regenerated cellulose membranes. Based on these results, we propose a correction factor and demonstrate its application to calculate the EE of two nanoformulations based on poly(epsilon-caprolactone) nanocarriers. The approach extends the applicability of centrifugal ultrafiltration to a wider range of pesticide nanoformulations. We also discuss the effect of dilution on EE and make recommendations to improve the characterisation of nanoparticles-based pesticide nanoformulations in the future.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

GA18-19324S, projekt VaV

Název: Nanopesticidy v životním prostředí – porozumění jejich osudu, biodostupnosti, účinkům a rizikům v půdě a vodě

Investor: Grantová agentura ČR, Nanopesticides in the environment – understanding their fate, bioavailability, effects and risks in soil and water

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

LÓPEZ CABEZA, María del Rocío; Mélanie Marie KAH; Renato GRILLO; Zuzana BÍLKOVÁ a Jakub HOFMAN. Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? Nanoscale. Cambridge: Royal Society of Chemistry, 2021, roč. 13, č. 10, s. 5410-5418. ISSN 2040-3364. Dostupné z: https://doi.org/10.1039/d0nr08693b.

@article{1789119,
   author = {López Cabeza, María del Rocío and Kah, Mélanie Marie and Grillo, Renato and Bílková, Zuzana and Hofman, Jakub},
   article_location = {Cambridge},
   article_number = {10},
   doi = {https://doi.org/10.1039/d0nr08693b},
   keywords = {Pesticides; nanoparticles; ultrafiltration},
   language = {eng},
   issn = {2040-3364},
   journal = {Nanoscale},
   title = {Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations?},
   url = {https://pubs.rsc.org/en/content/articlelanding/2021/NR/D0NR08693B},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1789119
AU  - López Cabeza, María del Rocío - Kah, Mélanie Marie - Grillo, Renato - Bílková, Zuzana - Hofman, Jakub
PY  - 2021
TI  - Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations?
JF  - Nanoscale
VL  - 13
IS  - 10
SP  - 5410-5418
EP  - 5410-5418
PB  - Royal Society of Chemistry
SN  - 20403364
KW  - Pesticides
KW  - nanoparticles
KW  - ultrafiltration
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/NR/D0NR08693B
N2  - Loading active ingredients on nanocarrier systems is becoming a common strategy for improving pesticide formulations. One of the most important properties of these nanoformulations is the proportion of pesticide associated with the nanocarriers (encapsulation efficiency, EE). EE is often determined by centrifugal ultrafiltration. However, the losses of active ingredient in the centrifugal ultrafiltration devices are typically not assessed, potentially leading to erroneous results. In this work, the losses of three pesticides (tebuconazole, terbuthylazine and chlorpyrifos) during centrifugal ultrafiltration have been systematically evaluated for nine different devices. Results suggest that centrifugal ultrafiltration is not suitable for determining the EE of compounds such as chlorpyrifos as 100% losses were observed on all the devices tested. Losses of tebuconazole and terbuthylazine were highly variable according to the type of membrane and the lowest losses were observed in the devices with hydrophilic regenerated cellulose membranes. Based on these results, we propose a correction factor and demonstrate its application to calculate the EE of two nanoformulations based on poly(epsilon-caprolactone) nanocarriers. The approach extends the applicability of centrifugal ultrafiltration to a wider range of pesticide nanoformulations. We also discuss the effect of dilution on EE and make recommendations to improve the characterisation of nanoparticles-based pesticide nanoformulations in the future.
ER  -

LÓPEZ CABEZA, María del Rocío; Mélanie Marie KAH; Renato GRILLO; Zuzana BÍLKOVÁ a Jakub HOFMAN. Is centrifugal ultrafiltration a robust method for determining encapsulation efficiency of pesticide nanoformulations? \textit{Nanoscale}. Cambridge: Royal Society of Chemistry, 2021, roč.~13, č.~10, s.~5410-5418. ISSN~2040-3364. Dostupné z: https://doi.org/10.1039/d0nr08693b.

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