Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18–30 Years Old): An Independent Post-Marketing Study

RIAD, Abanoub; Andrea POKORNÁ; Jitka KLUGAROVÁ; Natália ANTALOVÁ; Lucia KANTOROVÁ; Michal KOŠČÍK a Miloslav KLUGAR. Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18–30 Years Old): An Independent Post-Marketing Study. Pharmaceuticals. Basel: MDPI, 2021, roč. 14, č. 10, s. 1-16. ISSN 1424-8247. Dostupné z: https://doi.org/10.3390/ph14101049.

Základní údaje

Originální název

Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18–30 Years Old): An Independent Post-Marketing Study

Autoři

RIAD, Abanoub; Andrea POKORNÁ; Jitka KLUGAROVÁ; Natália ANTALOVÁ; Lucia KANTOROVÁ; Michal KOŠČÍK a Miloslav KLUGAR

Vydání

Pharmaceuticals, Basel, MDPI, 2021, 1424-8247

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.215

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/21:00122615

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.3390/ph14101049

UT WoS

000715120800001

EID Scopus

2-s2.0-85117941885

Klíčová slova anglicky

BNT162 vaccine; COVID-19; Czech Republic; drug-related side effects and adverse reactions; mass vaccination; mRNA-1273 vaccine; phase IV; prevalence; young adult

Štítky

14110525, 14110611, 14119612, 14119613, rivok

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Young adults had been widely perceived as a low-risk group for COVID-19 severity; therefore, they were deprioritised within the mass vaccination strategies as their prognosis of COVID-19 infection is relatively more favourable than older age groups. On the other hand, vaccination of this demographic group is indispensable to achieve herd immunity. A cross-sectional survey-based study was used to evaluate the side effects of mRNA-based COVID-19 vaccines among university students in the Czech Republic. The validated questionnaire was delivered in a digital form, and it consisted of demographic data; COVID-19 vaccine-related anamnesis; and local, systemic, orofacial, and skin-related side effects’ prevalence, onset, and duration. Out of the 539 included participants, 70.1% were females and 45.8% were <23 years old. The vast majority (95.2%) reported at least one side effect. The most common side effect was injection site pain (91.8%), followed by fatigue (62.5%), headache (36.4%), and muscle pain (34.9%). The majority of local side effects occurred after both doses (74.4%), while most systemic side effects occurred after the second dose only (56.2%). Most local (94.2%) and systemic (93.3%) side effects resolved within three days after vaccination. Females participants’ adjusted odds ratio (AOR) showed they were 2.566 (CI 95%: 1.103–5.970) times more likely to experience post-vaccination side effects, and the participants who received two doses reported an increased AOR of 1.896 (0.708–5.077) for experiencing side effects. The results of this study imply that mRNA-based COVID-19 vaccines are highly probably safe for young adults, and further studies are required to investigate the role of medical anamnesis, prior COVID-19 infection, and gender in side effects incidence.

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Návaznosti

LTC20031, projekt VaV	Název: Towards an International Network for Evidence-based Research in Clinical Health Research in the Czech Republic Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Towards an International Network for Evidence-based Research in Clinical Health Research in the Czech Republic, INTER-COST
MUNI/A/1608/2020, interní kód MU	Název: Prohlubování znalostí v oblasti zdravotních rizik a benefitů výživy, prostředí a životního stylu III Investor: Masarykova univerzita, Prohlubování znalostí v oblasti zdravotních rizik a benefitů výživy, prostředí a životního stylu III
MUNI/IGA/1068/2020, interní kód MU	Název: Methodological and practical aspects of the development of guidelines and rapid guidelines in public health (Akronym: RAPguidelines-public-health) Investor: Masarykova univerzita, Methodological and practical aspects of the development of guidelines and rapid guidelines in public health
MUNI/IGA/1543/2020, interní kód MU	Název: Evidence-based Practice of Healthcare Professionals and Students in the Czech Republic (Akronym: Evidence-Based Practice in Czechia) Investor: Masarykova univerzita, Evidence-based Practice of Healthcare Professionals and Students in the Czech Republic