Toxicity to bronchial cells and endocrine disruptive potentials
of indoor air and dust extracts and their association with
multiple chemical classes

J 2022

Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes

NOVÁKOVÁ, Zuzana, Jiří NOVÁK, Michal BITTNER, Pavel ČUPR, Petra PŘIBYLOVÁ et. al.

Basic information

Original name

Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes

Authors

NOVÁKOVÁ, Zuzana (203 Czech Republic, belonging to the institution), Jiří NOVÁK (203 Czech Republic, belonging to the institution), Michal BITTNER (203 Czech Republic, belonging to the institution), Pavel ČUPR (203 Czech Republic, belonging to the institution), Petra PŘIBYLOVÁ (203 Czech Republic, belonging to the institution), Petr KUKUČKA (203 Czech Republic, belonging to the institution), Marie SMUTNÁ (203 Czech Republic, belonging to the institution), Beate I. ESCHER (276 Germany), Hale DEMIRTEPE (792 Turkey), Ana Maria MIRALLES MARCO (724 Spain, belonging to the institution) and Klára HILSCHEROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Hazardous Materials, Amsterdam, Elsevier Science BV. 2022, 0304-3894

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 13.600

RIV identification code

RIV/00216224:14310/22:00119688

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.jhazmat.2021.127306

UT WoS

000711820200003

Keywords in English

Indoor air; Dust; Endocrine disruption; Bioassay; Mixture

Abstract

V originále

Pollution of indoor environment, where people spend much of their time, comprises complex mixtures of compounds with vastly understudied hazard potential. This study examined several important specific toxic effects and pollutant levels (177 compounds) of indoor samples (air gas phase, PM10 and dust) from different microenvironments after two extractions with focus on their gas/particle/dust distribution and polarity. The endocrine disruptive (ED) potential was assessed by human cell-based in vitro bioassays addressing anti-/ estrogenicity, anti-/androgenicity, aryl hydrocarbon, thyroid and peroxisome proliferator-activated receptormediated activities. Potential toxicity to respiratory tract tissue was assessed using human bronchial cell line. The toxicological analyses pointed out the relevance of both inhalation and ingestion exposure, with significant effects detected after exposure to extracts from all three studied matrices with distinct gas/particle distribution patterns. Chemical analyses document the high complexity of indoor pollutant mixtures with greatest levels of phthalates, their emerging alternatives, and PAHs in dust. Despite the detection of up to 108 chemicals, effects were explained only to low extent. This emphasizes data gaps regarding ED potencies of many detected abundant indoor contaminants, but also potential presence of other unidentified ED compounds. The omnipresent ED potentials in indoor environment rise concern regarding associated human health risk.

Links

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

GA19-20479S, research and development project

Name: Prach jako významný zdroj expozice člověka endokrinním disruptorům ve vnitřním protředí

Investor: Czech Science Foundation

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

857560, interní kód MU
(CEP code: EF17_043/0009632)

Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation

Citovat

NOVÁKOVÁ, Zuzana, Jiří NOVÁK, Michal BITTNER, Pavel ČUPR, Petra PŘIBYLOVÁ, Petr KUKUČKA, Marie SMUTNÁ, Beate I. ESCHER, Hale DEMIRTEPE, Ana Maria MIRALLES MARCO and Klára HILSCHEROVÁ. Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes. Journal of Hazardous Materials. Amsterdam: Elsevier Science BV., 2022, vol. 424, February 2022, p. 1-14. ISSN 0304-3894. Available from: https://dx.doi.org/10.1016/j.jhazmat.2021.127306.

@article{1838519,
   author = {Nováková, Zuzana and Novák, Jiří and Bittner, Michal and Čupr, Pavel and Přibylová, Petra and Kukučka, Petr and Smutná, Marie and Escher, Beate I. and Demirtepe, Hale and Miralles Marco, Ana Maria and Hilscherová, Klára},
   article_location = {Amsterdam},
   article_number = {February 2022},
   doi = {http://dx.doi.org/10.1016/j.jhazmat.2021.127306},
   keywords = {Indoor air; Dust; Endocrine disruption; Bioassay; Mixture},
   language = {eng},
   issn = {0304-3894},
   journal = {Journal of Hazardous Materials},
   title = {Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes},
   url = {https://www.sciencedirect.com/science/article/pii/S0304389421022743?via%3Dihub},
   volume = {424},
   year = {2022}
}

TY  - JOUR
ID  - 1838519
AU  - Nováková, Zuzana - Novák, Jiří - Bittner, Michal - Čupr, Pavel - Přibylová, Petra - Kukučka, Petr - Smutná, Marie - Escher, Beate I. - Demirtepe, Hale - Miralles Marco, Ana Maria - Hilscherová, Klára
PY  - 2022
TI  - Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes
JF  - Journal of Hazardous Materials
VL  - 424
IS  - February 2022
SP  - 1-14
EP  - 1-14
PB  - Elsevier Science BV.
SN  - 03043894
KW  - Indoor air
KW  - Dust
KW  - Endocrine disruption
KW  - Bioassay
KW  - Mixture
UR  - https://www.sciencedirect.com/science/article/pii/S0304389421022743?via%3Dihub
N2  - Pollution of indoor environment, where people spend much of their time, comprises complex mixtures of compounds with vastly understudied hazard potential. This study examined several important specific toxic effects and pollutant levels (177 compounds) of indoor samples (air gas phase, PM10 and dust) from different microenvironments after two extractions with focus on their gas/particle/dust distribution and polarity. The endocrine disruptive (ED) potential was assessed by human cell-based in vitro bioassays addressing anti-/ estrogenicity, anti-/androgenicity, aryl hydrocarbon, thyroid and peroxisome proliferator-activated receptormediated activities. Potential toxicity to respiratory tract tissue was assessed using human bronchial cell line. The toxicological analyses pointed out the relevance of both inhalation and ingestion exposure, with significant effects detected after exposure to extracts from all three studied matrices with distinct gas/particle distribution patterns. Chemical analyses document the high complexity of indoor pollutant mixtures with greatest levels of phthalates, their emerging alternatives, and PAHs in dust. Despite the detection of up to 108 chemicals, effects were explained only to low extent. This emphasizes data gaps regarding ED potencies of many detected abundant indoor contaminants, but also potential presence of other unidentified ED compounds. The omnipresent ED potentials in indoor environment rise concern regarding associated human health risk.
ER  -

NOVÁKOVÁ, Zuzana, Jiří NOVÁK, Michal BITTNER, Pavel ČUPR, Petra PŘIBYLOVÁ, Petr KUKUČKA, Marie SMUTNÁ, Beate I. ESCHER, Hale DEMIRTEPE, Ana Maria MIRALLES MARCO and Klára HILSCHEROVÁ. Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2022, vol.~424, February 2022, p.~1-14. ISSN~0304-3894. Available from: https://dx.doi.org/10.1016/j.jhazmat.2021.127306.

Detailed Information on Publication Record