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@article{1846403,
author = {Bartáková, Julie and Deissová, Tereza and Slezáková, Simona and Bartova, Jirina and Petanova, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Bořilová Linhartová, Petra and Dušek, Ladislav and Izakovičová Hollá, Lydie},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1186/s12903-022-02115-3},
keywords = {Recurrent aphthous stomatitis; Angiotensin I converting enzyme; Polymorphism; Haplotype; Sex difference},
language = {eng},
issn = {1472-6831},
journal = {BMC Oral Health},
title = {Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study},
url = {https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3},
volume = {22},
year = {2022}
}
TY - JOUR
ID - 1846403
AU - Bartáková, Julie - Deissová, Tereza - Slezáková, Simona - Bartova, Jirina - Petanova, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Bořilová Linhartová, Petra - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY - 2022
TI - Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study
JF - BMC Oral Health
VL - 22
IS - 1
SP - 1-9
EP - 1-9
PB - BMC
SN - 14726831
KW - Recurrent aphthous stomatitis
KW - Angiotensin I converting enzyme
KW - Polymorphism
KW - Haplotype
KW - Sex difference
UR - https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3
N2 - Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P-corr > 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P < 0.035, P-corr > 0.05, respectively) than in men with RAS (P > 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, P-corr < 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P < 0.00001) and CGI haplotype was less frequent in RAS patients (P < 0.01), especially in women (P = 0.016, P-corr > 0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.
ER -
BARTÁKOVÁ, Julie, Tereza DEISSOVÁ, Simona SLEZÁKOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN, Petra BOŘILOVÁ LINHARTOVÁ, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study. \textit{BMC Oral Health}. London: BMC, 2022, roč.~22, č.~1, s.~1-9. ISSN~1472-6831. Dostupné z: https://dx.doi.org/10.1186/s12903-022-02115-3.
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