SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS

BALLAYOVÁ, Veronika, Radka ŽÁČKOVÁ, Tereza KAUEROVÁ, Peter KOLLÁR a Oldřich FARSA. SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS. 2022.

Základní údaje

• Originální název: SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
• Název česky: SCHIFF BASES AS POTENTIAL INHIBITORS OF AMINOPEPTIDASE N AS ANTICANCER AGENTS
• Autoři: BALLAYOVÁ, Veronika (703 Slovensko, garant, domácí), Radka ŽÁČKOVÁ (203 Česká republika, domácí), Tereza KAUEROVÁ (203 Česká republika, domácí), Peter KOLLÁR (203 Česká republika, domácí) a Oldřich FARSA (203 Česká republika, domácí).
• Vydání: 2022.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Prezentace na konferencích
• Obor: 30107 Medicinal chemistry
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• Kód RIV: RIV/00216224:14160/22:00126659
• Organizační jednotka: Farmaceutická fakulta
• Klíčová slova česky: Aminopeptidase N; AP-N; HPLC assay
• Klíčová slova anglicky: Aminopeptidase N; AP-N; HPLC assay

Anotace

Many Schiff bases appear to be important intermediates in a number of enzymatic reactions. The presence of the azomethine group, as well as their interesting physical and chemical properties, cause the widespread application of their metal complexes. Synthesized groups of basic thiosemicarbazone and semicarbazone derivatives of acetophenone have these properties as well. Aminopeptidase N (AP-N), or membrane alanyl aminopeptidase (m-AAP), is a neutral zinc-binding metallopeptidase that cleaves N-terminal residues from protein and peptides. This aminopeptidase turns out to be identical to the human cluster differentiation antigen CD13 expressed on the surface of myeloid progenitors and myeloid leukemia cells.

Anotace česky

Many Schiff bases appear to be important intermediates in a number of enzymatic reactions. The presence of the azomethine group, as well as their interesting physical and chemical properties, cause the widespread application of their metal complexes. Synthesized groups of basic thiosemicarbazone and semicarbazone derivatives of acetophenone have these properties as well. Aminopeptidase N (AP-N), or membrane alanyl aminopeptidase (m-AAP), is a neutral zinc-binding metallopeptidase that cleaves N-terminal residues from protein and peptides. This aminopeptidase turns out to be identical to the human cluster differentiation antigen CD13 expressed on the surface of myeloid progenitors and myeloid leukemia cells.

Návaznosti

• MUNI/IGA/0932/2021, interní kód MU: Název: Basic ketones and their derivatives as potential anti-infective and anti-tumor drugs

Investor: Masarykova univerzita, Basic ketones and their derivatives as potential anti-infective and anti-tumor drugs