Combinatorial pathway disruption is a powerful approach to
delineate metabolic impacts of endocrine disruptors

J 2022

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

BERNAL, Kevin; Charbel TOUMA; Chedi ERRADHOUANI; Talia BORONAT-BELDA; Lucas GAILLARD et al.

Základní údaje

Originální název

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

Autoři

Vydání

FEBS Letters, Hoboken, Wiley, 2022, 0014-5793

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.500

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00127970

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

appetite; bisphenol; dioxin; inflammation; insulin resistance; microbiota; perfluorinated compounds; phthalate; TBT

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 6. 2025 11:13, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will propose an integrated pathophysiological vision of their effects on several organs. With regard to these pathomechanisms, we will discuss the needs, and the stakes of evolving the testing and assessment of endocrine disruptors to improve the prevention and management of metabolic diseases that have become a global epidemic since the end of last century.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

825712, interní kód MU

Název: An integrative strategy of testing systems for identification of EDs related to metabolic disorders (Akronym: OBERON)

Investor: Evropská unie, An integrative strategy of testing systems for identification of EDs related to metabolic disorders, Health, demographic change and wellbeing (Societal Challenges)

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Přiložené soubory

2246439.pdf

Citovat

BERNAL, Kevin; Charbel TOUMA; Chedi ERRADHOUANI; Talia BORONAT-BELDA; Lucas GAILLARD; Sara AL KASSIR; Helene LE MENTEC; Corinne MARTIN-CHOULY; Normand PODECHARD; Dominique LAGADIC-GOSSMANN; Sophie LANGOUET; Francois BRION; Anja KNOLL-GELLIDA; Patrick J. BABIN; Iva SOVADINOVÁ; Pavel BABICA; Karine ANDREAU; Robert BAROUKI; Jan VONDRACEK; Paloma ALONSO-MAGDALENA; Etienne BLANC; Min Ji KIM a Xavier COUMOUL. Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors. FEBS Letters. Hoboken: Wiley, 2022, roč. 596, č. 24, s. 3107-3123. ISSN 0014-5793. Dostupné z: https://doi.org/10.1002/1873-3468.14465.

@article{2246439,
   author = {Bernal, Kevin and Touma, Charbel and Erradhouani, Chedi and BoronatandBelda, Talia and Gaillard, Lucas and Al Kassir, Sara and Le Mentec, Helene and MartinandChouly, Corinne and Podechard, Normand and LagadicandGossmann, Dominique and Langouet, Sophie and Brion, Francois and KnollandGellida, Anja and Babin, Patrick J. and Sovadinová, Iva and Babica, Pavel and Andreau, Karine and Barouki, Robert and Vondracek, Jan and AlonsoandMagdalena, Paloma and Blanc, Etienne and Kim, Min Ji and Coumoul, Xavier},
   article_location = {Hoboken},
   article_number = {24},
   doi = {https://doi.org/10.1002/1873-3468.14465},
   keywords = {appetite; bisphenol; dioxin; inflammation; insulin resistance; microbiota; perfluorinated compounds; phthalate; TBT},
   language = {eng},
   issn = {0014-5793},
   journal = {FEBS Letters},
   title = {Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors},
   url = {https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14465},
   volume = {596},
   year = {2022}
}

TY  - JOUR
ID  - 2246439
AU  - Bernal, Kevin - Touma, Charbel - Erradhouani, Chedi - Boronat-Belda, Talia - Gaillard, Lucas - Al Kassir, Sara - Le Mentec, Helene - Martin-Chouly, Corinne - Podechard, Normand - Lagadic-Gossmann, Dominique - Langouet, Sophie - Brion, Francois - Knoll-Gellida, Anja - Babin, Patrick J. - Sovadinová, Iva - Babica, Pavel - Andreau, Karine - Barouki, Robert - Vondracek, Jan - Alonso-Magdalena, Paloma - Blanc, Etienne - Kim, Min Ji - Coumoul, Xavier
PY  - 2022
TI  - Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors
JF  - FEBS Letters
VL  - 596
IS  - 24
SP  - 3107-3123
EP  - 3107-3123
PB  - Wiley
SN  - 00145793
KW  - appetite
KW  - bisphenol
KW  - dioxin
KW  - inflammation
KW  - insulin resistance
KW  - microbiota
KW  - perfluorinated compounds
KW  - phthalate
KW  - TBT
UR  - https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14465
N2  - The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will propose an integrated pathophysiological vision of their effects on several organs. With regard to these pathomechanisms, we will discuss the needs, and the stakes of evolving the testing and assessment of endocrine disruptors to improve the prevention and management of metabolic diseases that have become a global epidemic since the end of last century.
ER  -

BERNAL, Kevin; Charbel TOUMA; Chedi ERRADHOUANI; Talia BORONAT-BELDA; Lucas GAILLARD; Sara AL KASSIR; Helene LE MENTEC; Corinne MARTIN-CHOULY; Normand PODECHARD; Dominique LAGADIC-GOSSMANN; Sophie LANGOUET; Francois BRION; Anja KNOLL-GELLIDA; Patrick J. BABIN; Iva SOVADINOVÁ; Pavel BABICA; Karine ANDREAU; Robert BAROUKI; Jan VONDRACEK; Paloma ALONSO-MAGDALENA; Etienne BLANC; Min Ji KIM a Xavier COUMOUL. Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors. \textit{FEBS Letters}. Hoboken: Wiley, 2022, roč.~596, č.~24, s.~3107-3123. ISSN~0014-5793. Dostupné z: https://doi.org/10.1002/1873-3468.14465.

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