Association of CDX2 haplogenotype with risk of reflux
esophagitis, Barrett´s esophagus, and esophageal adenocarcinoma
development

a 2023

Association of CDX2 haplogenotype with risk of reflux esophagitis, Barrett´s esophagus, and esophageal adenocarcinoma development

BOŘILOVÁ LINHARTOVÁ, Petra; Natálie MLČŮCHOVÁ; Michaela CVANOVÁ; Zdeněk PAVLOVSKÝ; Miroslava CHOVANCOVÁ et al.

Základní údaje

Originální název

Association of CDX2 haplogenotype with risk of reflux esophagitis, Barrett´s esophagus, and esophageal adenocarcinoma development

Autoři

Vydání

Cancer World congress, Palermo 2023, 2023

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/23:00131174

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

CDX2; gastroesophageal reflux disease; esophagitis; markers

Změněno: 7. 7. 2023 10:39, Mgr. Terezie Slámová

Anotace

V originále

Introduction: Gastroesophageal reflux disease (GERD) can lead to reflux esophagitis (RE), Barrett’s esophagus (BE), and esophageal adenocarcinoma (EAC) development. CDX2 serves as a diagnostic marker for BE and EAC. Objective: Here, we present a genetic association study focused on CDX2 gene variability in Central European patients with GERD. Methods: In 376 endoscopically and histopathologically examined subjects: 279 cases (144 RE, 88 BE, 47 EAC) and 97 controls with nonerosive reflux disease, NERD), genomic DNA was analyzed for 2 polymorphisms in CDX2 (rs3812863, rs4769585). In a subgroup of cases (n=35), CDX2 was immunohistochemically examined in paired pathological and adjacent tissues of esophagus. Results: The distribution of allele frequencies of both CDX2 (rs3812863, rs4769585) polymorphisms differed between cases and controls, the CC genotype (rs4769585) was associated with risk of RE, BE, and EAC development (p≤0.05). The CDX2 AA/CC haplogenotype was found more frequent in cases than in controls (p<0.01). CDX2 protein was found in all BE (n=19) and EAC tissues (n=6), as well as in 3 RE tissues and in 2 esophageal tissue adjacent to lesions (n=35). Conclusion: The CDX2 is a specific tissue marker for BE and EAC diagnosis; variability in the CDX2 gene affects the risk of GERD development.

Návaznosti

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

NU20-03-00126, projekt VaV

Název: Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu

Investor: Ministerstvo zdravotnictví ČR, Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu, Podprogram 1 - standardní

Citovat

BOŘILOVÁ LINHARTOVÁ, Petra; Natálie MLČŮCHOVÁ; Michaela CVANOVÁ; Zdeněk PAVLOVSKÝ; Miroslava CHOVANCOVÁ; Jiří DOLINA; Lumír KUNOVSKÝ; Radek KROUPA; Lydie IZAKOVIČOVÁ HOLLÁ; Ondřej URBAN; Tomáš HARUŠTIAK a Zdeněk KALA. Association of CDX2 haplogenotype with risk of reflux esophagitis, Barrett´s esophagus, and esophageal adenocarcinoma development. In Cancer World congress, Palermo 2023. 2023.

@proceedings{2296500,
   author = {Bořilová Linhartová, Petra and Mlčůchová, Natálie and Cvanová, Michaela and Pavlovský, Zdeněk and Chovancová, Miroslava and Dolina, Jiří and Kunovský, Lumír and Kroupa, Radek and Izakovičová Hollá, Lydie and Urban, Ondřej and Haruštiak, Tomáš and Kala, Zdeněk},
   booktitle = {Cancer World congress, Palermo 2023},
   keywords = {CDX2; gastroesophageal reflux disease; esophagitis; markers},
   language = {eng},
   title = {Association of CDX2 haplogenotype with risk of reflux esophagitis, Barrett´s esophagus, and esophageal adenocarcinoma development},
   year = {2023}
}

TY  - CONF
ID  - 2296500
AU  - Bořilová Linhartová, Petra - Mlčůchová, Natálie - Cvanová, Michaela - Pavlovský, Zdeněk - Chovancová, Miroslava - Dolina, Jiří - Kunovský, Lumír - Kroupa, Radek - Izakovičová Hollá, Lydie - Urban, Ondřej - Haruštiak, Tomáš - Kala, Zdeněk
PY  - 2023
TI  - Association of CDX2 haplogenotype with risk of reflux esophagitis, Barrett´s esophagus, and esophageal adenocarcinoma development
KW  - CDX2
KW  - gastroesophageal reflux disease
KW  - esophagitis
KW  - markers
N2  - Introduction: Gastroesophageal reflux disease (GERD) can lead to reflux esophagitis (RE), Barrett’s esophagus (BE), and esophageal adenocarcinoma (EAC) development. CDX2 serves as a diagnostic marker for BE and EAC. Objective: Here, we present a genetic association study focused on CDX2 gene variability in Central European patients with GERD. Methods: In 376 endoscopically and histopathologically examined subjects: 279 cases (144 RE, 88 BE, 47 EAC) and 97 controls with nonerosive reflux disease, NERD), genomic DNA was analyzed for 2 polymorphisms in CDX2 (rs3812863, rs4769585). In a subgroup of cases (n=35), CDX2 was immunohistochemically examined in paired pathological and adjacent tissues of esophagus. Results: The distribution of allele frequencies of both CDX2 (rs3812863, rs4769585) polymorphisms differed between cases and controls, the CC genotype (rs4769585) was associated with risk of RE, BE, and EAC development (p≤0.05). The CDX2 AA/CC haplogenotype was found more frequent in cases than in controls (p<0.01). CDX2 protein was found in all BE (n=19) and EAC tissues (n=6), as well as in 3 RE tissues and in 2 esophageal tissue adjacent to lesions (n=35). Conclusion: The CDX2 is a specific tissue marker for BE and EAC diagnosis; variability in the CDX2 gene affects the risk of GERD development.
ER  -

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