Impact of PFAS exposure on prevalence of immune-mediated
diseases in adults in the Czech Republic

J 2023

Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic

RUDZANOVÁ, Barbora; Jelle VLAANDEREN; Jiří KALINA; Pavel PILER; Martin ZVONAŘ et al.

Základní údaje

Originální název

Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic

Autoři

RUDZANOVÁ, Barbora; Jelle VLAANDEREN; Jiří KALINA; Pavel PILER ; Martin ZVONAŘ; Jana KLÁNOVÁ; Luděk BLÁHA a Ondřej ADAMOVSKÝ

Vydání

Environmental Research, Elsevier, 2023, 0013-9351

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.700

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/23:00131221

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Perfluoroalkyl substances; Immune system; Adult cohort; Allergy; Eczema; Bayesian kernel machine regression

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 3. 2024 22:14, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Background: Per-and polyfluoroalkyl substances (PFASs) are emerging environmental contaminants with mul-tiple hazardous properties including immunomodulation potency. Human exposure to PFASs has been associated with various immune-mediated diseases and outcomes. This study aimed to investigate the association between PFAS exposure and immune-mediated diseases such as allergies, eczemas, and autoimmune diseases in a pop-ulation of adults in the Czech Republic.Methods: This study included 309 adults from the Central European Longitudinal Study of Parents and Children: Young Adults (CELSPAC: YA). 12 PFASs were measured in participants' serum by HPLC-MS/MS, 3 PFASs were removed from the subsequent analyses due to low detection frequency. The associations of 9 PFASs with 9 immune-mediated diseases were assessed by logistic regression. Furthermore, Bayesian kernel machine regres-sion (BKMR) was used to estimate the effect of the PFAS mixture on immune-mediated diseases. All analyses were adjusted for sex, age, BMI, smoking, education, and family history of immune-mediated diseases. In cases of a statistically significant interaction of PFASs and sex, stratified analyses were performed for men and women.Results: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were negatively associated with both atopic eczema (OR per IQR increase 0.58 (95% CI 0.37-0.90) for PFOA and 0.56 (0.32-0.95) for PFOS) and contact dermatitis (0.37 (0.16-0.85) for PFOA and 0.33 (0.11-0.94) for PFOS). Perfluoroundecanoate (PFUnDA) was negatively associated with pollen, dust, and mite allergy (0.62 (0.43-0.89)). BKMR modelling showed a negative tendency in the overall effect of PFAS mixture on immune-health outcomes. Based on the stratified analysis, sex was suggested to be an effect modifier in the association of PFOS and atopic eczema.Conclusion: Our results contribute to the body of literature that observes the immunosuppressive effect of PFAS exposure during eczemas and allergies, both for PFASs individually and as a mixture.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

RUDZANOVÁ, Barbora; Jelle VLAANDEREN; Jiří KALINA; Pavel PILER; Martin ZVONAŘ; Jana KLÁNOVÁ; Luděk BLÁHA a Ondřej ADAMOVSKÝ. Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic. Environmental Research. Elsevier, 2023, roč. 229, July 2023, s. 1-12. ISSN 0013-9351. Dostupné z: https://doi.org/10.1016/j.envres.2023.115969.

@article{2297182,
   author = {Rudzanová, Barbora and Vlaanderen, Jelle and Kalina, Jiří and Piler, Pavel and Zvonař, Martin and Klánová, Jana and Bláha, Luděk and Adamovský, Ondřej},
   article_number = {July 2023},
   doi = {https://doi.org/10.1016/j.envres.2023.115969},
   keywords = {Perfluoroalkyl substances; Immune system; Adult cohort; Allergy; Eczema; Bayesian kernel machine regression},
   language = {eng},
   issn = {0013-9351},
   journal = {Environmental Research},
   title = {Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic},
   url = {https://www.sciencedirect.com/science/article/pii/S0013935123007612?via%3Dihub},
   volume = {229},
   year = {2023}
}

TY  - JOUR
ID  - 2297182
AU  - Rudzanová, Barbora - Vlaanderen, Jelle - Kalina, Jiří - Piler, Pavel - Zvonař, Martin - Klánová, Jana - Bláha, Luděk - Adamovský, Ondřej
PY  - 2023
TI  - Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic
JF  - Environmental Research
VL  - 229
IS  - July 2023
SP  - 1-12
EP  - 1-12
PB  - Elsevier
SN  - 00139351
KW  - Perfluoroalkyl substances
KW  - Immune system
KW  - Adult cohort
KW  - Allergy
KW  - Eczema
KW  - Bayesian kernel machine regression
UR  - https://www.sciencedirect.com/science/article/pii/S0013935123007612?via%3Dihub
N2  - Background: Per-and polyfluoroalkyl substances (PFASs) are emerging environmental contaminants with mul-tiple hazardous properties including immunomodulation potency. Human exposure to PFASs has been associated with various immune-mediated diseases and outcomes. This study aimed to investigate the association between PFAS exposure and immune-mediated diseases such as allergies, eczemas, and autoimmune diseases in a pop-ulation of adults in the Czech Republic.Methods: This study included 309 adults from the Central European Longitudinal Study of Parents and Children: Young Adults (CELSPAC: YA). 12 PFASs were measured in participants' serum by HPLC-MS/MS, 3 PFASs were removed from the subsequent analyses due to low detection frequency. The associations of 9 PFASs with 9 immune-mediated diseases were assessed by logistic regression. Furthermore, Bayesian kernel machine regres-sion (BKMR) was used to estimate the effect of the PFAS mixture on immune-mediated diseases. All analyses were adjusted for sex, age, BMI, smoking, education, and family history of immune-mediated diseases. In cases of a statistically significant interaction of PFASs and sex, stratified analyses were performed for men and women.Results: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were negatively associated with both atopic eczema (OR per IQR increase 0.58 (95% CI 0.37-0.90) for PFOA and 0.56 (0.32-0.95) for PFOS) and contact dermatitis (0.37 (0.16-0.85) for PFOA and 0.33 (0.11-0.94) for PFOS). Perfluoroundecanoate (PFUnDA) was negatively associated with pollen, dust, and mite allergy (0.62 (0.43-0.89)). BKMR modelling showed a negative tendency in the overall effect of PFAS mixture on immune-health outcomes. Based on the stratified analysis, sex was suggested to be an effect modifier in the association of PFOS and atopic eczema.Conclusion: Our results contribute to the body of literature that observes the immunosuppressive effect of PFAS exposure during eczemas and allergies, both for PFASs individually and as a mixture.
ER  -

RUDZANOVÁ, Barbora; Jelle VLAANDEREN; Jiří KALINA; Pavel PILER; Martin ZVONAŘ; Jana KLÁNOVÁ; Luděk BLÁHA a Ondřej ADAMOVSKÝ. Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic. \textit{Environmental Research}. Elsevier, 2023, roč.~229, July 2023, s.~1-12. ISSN~0013-9351. Dostupné z: https://doi.org/10.1016/j.envres.2023.115969.

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