Primary cilia and hypoxia-associated signaling in developmental
odontogenic cysts in relation to autosomal dominant polycystic
kidney disease-A novel insight

J 2023

Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease-A novel insight

SZÁRAZ, Dávid; Zdeněk DANĚK; Břetislav LIPOVÝ; Jan KŘIVÁNEK; Marcela BUCHTOVÁ et al.

Základní údaje

Originální název

Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease-A novel insight

Autoři

Vydání

Heliyon, OXFORD, Elsevier, 2023, 2405-8440

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10605 Developmental biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.400

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/23:00131550

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Developmental odontogenic cyst; Dentigerous cyst; Odontogenic keratocyst; Polycystic kidney disease; Primary cilia; Sonic hedgehog pathway; Polycystin

Štítky

14110130, 14110213, 14110216, 14110227, 14110229, 14110517, 14314010, 143180, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 3. 2024 12:41, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Developmental cysts are pathological epithelial-lined cavities arising in various organs as a result of systemic or hereditary diseases. Molecular mechanisms involved in the formation of devel-opmental odontogenic cysts (OCs) are not fully understood yet; the cystogenesis of renal cysts originating from the autosomal dominant polycystic kidney disease (ADPKD) has been, however, explored in much greater detail. This narrative review aimed i) to summarize molecular and cellular processes involved in the formation and growth of developmental OCs, especially den-tigerous cysts (DCs) and odontogenic keratocysts (OKCs), ii) to find if there are any similarities in their cystogenesis to ADPKD cysts, and, based on that, iii) to suggest potential factors, candidate molecules, and mechanisms that could be involved in the DC formation, thus proposing further research directions. Here we suggest a possible association of developmental OCs with primary cilia disruption and with hypoxia, which have been previously linked with cyst formation in ADPKD patients. This is illustrated on the imagery of tissues from an ADPKD patient (renal cyst) and from developmental OCs, supporting the similarities in cell proliferation, apoptosis, and primary cilia distribution in DC/OKC/ADPKD tissues. Based on all that, we propose a novel hy-pothesis of OCs formation suggesting a crucial role of mutations associated with the signaling pathways of primary cilia (in particular, Sonic Hedgehog). These can lead to excessive prolifer-ation and formation of cell agglomerates, which is followed by hypoxia-driven apoptosis in the centers of such agglomerates (controlled by molecules such as Hypoxia-inducible factor-1 alpha), leading to cavity formation and, finally, the OCs development. Based on this, we propose future perspectives in the investigation of OC pathogenesis.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

NU20-08-00205, projekt VaV

Název: Molekulární etiopatogeneze apikální periodontitidy a odontogenních cyst

Investor: Ministerstvo zdravotnictví ČR, Molekulární etiopatogeneze apikální periodontitidy a odontogenních cyst, Podprogram 1 - standardní

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90269, velká výzkumná infrastruktura

Název: RECETOX RI II

Přiložené soubory

2305217.pdf

Citovat

SZÁRAZ, Dávid; Zdeněk DANĚK; Břetislav LIPOVÝ; Jan KŘIVÁNEK; Marcela BUCHTOVÁ; Barbora Moldovan PUTNOVA; Iveta PUTNOVA; Jan ŠTEMBÍREK; Tomáš ANDRAŠINA; Petra DIVÁCKÁ; Lydie IZAKOVIČOVÁ HOLLÁ a Petra BOŘILOVÁ LINHARTOVÁ. Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease-A novel insight. Heliyon. OXFORD: Elsevier, 2023, roč. 9, č. 6, s. 1-12. ISSN 2405-8440. Dostupné z: https://doi.org/10.1016/j.heliyon.2023.e17130.

@article{2305217,
   author = {Száraz, Dávid and Daněk, Zdeněk and Lipový, Břetislav and Křivánek, Jan and Buchtová, Marcela and Putnova, Barbora Moldovan and Putnova, Iveta and Štembírek, Jan and Andrašina, Tomáš and Divácká, Petra and Izakovičová Hollá, Lydie and Bořilová Linhartová, Petra},
   article_location = {OXFORD},
   article_number = {6},
   doi = {https://doi.org/10.1016/j.heliyon.2023.e17130},
   keywords = {Developmental odontogenic cyst; Dentigerous cyst; Odontogenic keratocyst; Polycystic kidney disease; Primary cilia; Sonic hedgehog pathway; Polycystin},
   language = {eng},
   issn = {2405-8440},
   journal = {Heliyon},
   title = {Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease-A novel insight},
   url = {https://doi.org/10.1016/j.heliyon.2023.e17130},
   volume = {9},
   year = {2023}
}

TY  - JOUR
ID  - 2305217
AU  - Száraz, Dávid - Daněk, Zdeněk - Lipový, Břetislav - Křivánek, Jan - Buchtová, Marcela - Putnova, Barbora Moldovan - Putnova, Iveta - Štembírek, Jan - Andrašina, Tomáš - Divácká, Petra - Izakovičová Hollá, Lydie - Bořilová Linhartová, Petra
PY  - 2023
TI  - Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease-A novel insight
JF  - Heliyon
VL  - 9
IS  - 6
SP  - 1-12
EP  - 1-12
PB  - Elsevier
SN  - 24058440
KW  - Developmental odontogenic cyst
KW  - Dentigerous cyst
KW  - Odontogenic keratocyst
KW  - Polycystic kidney disease
KW  - Primary cilia
KW  - Sonic hedgehog pathway
KW  - Polycystin
UR  - https://doi.org/10.1016/j.heliyon.2023.e17130
N2  - Developmental cysts are pathological epithelial-lined cavities arising in various organs as a result of systemic or hereditary diseases. Molecular mechanisms involved in the formation of devel-opmental odontogenic cysts (OCs) are not fully understood yet; the cystogenesis of renal cysts originating from the autosomal dominant polycystic kidney disease (ADPKD) has been, however, explored in much greater detail. This narrative review aimed i) to summarize molecular and cellular processes involved in the formation and growth of developmental OCs, especially den-tigerous cysts (DCs) and odontogenic keratocysts (OKCs), ii) to find if there are any similarities in their cystogenesis to ADPKD cysts, and, based on that, iii) to suggest potential factors, candidate molecules, and mechanisms that could be involved in the DC formation, thus proposing further research directions. Here we suggest a possible association of developmental OCs with primary cilia disruption and with hypoxia, which have been previously linked with cyst formation in ADPKD patients. This is illustrated on the imagery of tissues from an ADPKD patient (renal cyst) and from developmental OCs, supporting the similarities in cell proliferation, apoptosis, and primary cilia distribution in DC/OKC/ADPKD tissues. Based on all that, we propose a novel hy-pothesis of OCs formation suggesting a crucial role of mutations associated with the signaling pathways of primary cilia (in particular, Sonic Hedgehog). These can lead to excessive prolifer-ation and formation of cell agglomerates, which is followed by hypoxia-driven apoptosis in the centers of such agglomerates (controlled by molecules such as Hypoxia-inducible factor-1 alpha), leading to cavity formation and, finally, the OCs development. Based on this, we propose future perspectives in the investigation of OC pathogenesis.
ER  -

SZÁRAZ, Dávid; Zdeněk DANĚK; Břetislav LIPOVÝ; Jan KŘIVÁNEK; Marcela BUCHTOVÁ; Barbora Moldovan PUTNOVA; Iveta PUTNOVA; Jan ŠTEMBÍREK; Tomáš ANDRAŠINA; Petra DIVÁCKÁ; Lydie IZAKOVIČOVÁ HOLLÁ a Petra BOŘILOVÁ LINHARTOVÁ. Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease-A novel insight. \textit{Heliyon}. OXFORD: Elsevier, 2023, roč.~9, č.~6, s.~1-12. ISSN~2405-8440. Dostupné z: https://doi.org/10.1016/j.heliyon.2023.e17130.

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