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@article{2312638, author = {Kovařovic, Vojtěch and Finstrlová, Adéla and Sedláček, Ivo and Petráš, Petr and Švec, Pavel and Mašlaňová, Ivana and NeumannandSchaal, Meina and Šedo, Ondrej and Botka, Tibor and Staňková, Eva and Doškař, Jiří and Pantůček, Roman}, article_location = {Washington, DC}, article_number = {5}, doi = {http://dx.doi.org/10.1128/spectrum.01342-23}, keywords = {coagulase-negative staphylococci; phylogenetic analysis; comparative genomics; mobile genetic elements; genomic islands; cassette chromosome recombinase; polyphasic taxonomy; gram-positive pathogens}, language = {eng}, issn = {2165-0497}, journal = {Microbiology Spectrum}, title = {Staphylococcus brunensis sp. nov. isolated from human clinical specimens with a staphylococcal cassette chromosome-related genomic island outside of the rlmH gene bearing the ccrDE recombinase gene complex}, url = {https://doi.org/10.1128/spectrum.01342-23}, volume = {11}, year = {2023} }
TY - JOUR ID - 2312638 AU - Kovařovic, Vojtěch - Finstrlová, Adéla - Sedláček, Ivo - Petráš, Petr - Švec, Pavel - Mašlaňová, Ivana - Neumann-Schaal, Meina - Šedo, Ondrej - Botka, Tibor - Staňková, Eva - Doškař, Jiří - Pantůček, Roman PY - 2023 TI - Staphylococcus brunensis sp. nov. isolated from human clinical specimens with a staphylococcal cassette chromosome-related genomic island outside of the rlmH gene bearing the ccrDE recombinase gene complex JF - Microbiology Spectrum VL - 11 IS - 5 SP - 1-22 EP - 1-22 PB - American Society for Microbiology SN - 21650497 KW - coagulase-negative staphylococci KW - phylogenetic analysis KW - comparative genomics KW - mobile genetic elements KW - genomic islands KW - cassette chromosome recombinase KW - polyphasic taxonomy KW - gram-positive pathogens UR - https://doi.org/10.1128/spectrum.01342-23 N2 - Novel species of coagulase-negative staphylococci, which could serve as reservoirs of virulence and antimicrobial resistance factors for opportunistic pathogens from the genus Staphylococcus, are recognized in human and animal specimens due to advances in diagnostic techniques. Here, we used whole-genome sequencing, extensive biotyping, MALDI-TOF mass spectrometry, and chemotaxonomy to characterize five coagulase-negative strains from the Staphylococcus haemolyticus phylogenetic clade obtained from human ear swabs, wounds, and bile. Based on the results of polyphasic taxonomy, we propose the species Staphylococcus brunensis sp. nov. (type strain NRL/St 16/872T = CCM 9024T = LMG 31872T = DSM 111349T). The genomic analysis revealed numerous variable genomic elements, including staphylococcal cassette chromosome (SCC), prophages, plasmids, and a unique 18.8 kb-long genomic island SbCIccrDE integrated into the ribosomal protein L7 serine acetyltransferase gene rimL. SbCIccrDE has a cassette chromosome recombinase (ccr) gene complex with a typical structure found in SCCs. Based on nucleotide and amino acid identity to other known ccr genes and the distinct integration site that differs from the canonical methyltransferase gene rlmH exploited by SCCs, we classified the ccr genes as novel variants, ccrDE. The comparative genomic analysis of SbCIccrDE with related islands shows that they can accumulate virulence and antimicrobial resistance factors creating novel resistance elements, which reflects the evolution of SCC. The spread of these resistance islands into established pathogens such as Staphylococcus aureus would pose a great threat to the healthcare system. ER -
KOVAŘOVIC, Vojtěch, Adéla FINSTRLOVÁ, Ivo SEDLÁČEK, Petr PETRÁŠ, Pavel ŠVEC, Ivana MAŠLAŇOVÁ, Meina NEUMANN-SCHAAL, Ondrej ŠEDO, Tibor BOTKA, Eva STAŇKOVÁ, Jiří DOŠKAŘ a Roman PANTŮČEK. Staphylococcus brunensis sp. nov. isolated from human clinical specimens with a staphylococcal cassette chromosome-related genomic island outside of the rlmH gene bearing the ccrDE recombinase gene complex. \textit{Microbiology Spectrum}. Washington, DC: American Society for Microbiology, 2023, roč.~11, č.~5, s.~1-22. ISSN~2165-0497. Dostupné z: https://dx.doi.org/10.1128/spectrum.01342-23.
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