DUBOVÝ, Petr, Ivana SVÍŽENSKÁ, Radim JANČÁLEK, Ilona KLUSÁKOVÁ, Ladislav HOUŠŤAVA and Pavel HANINEC. Immunohistochemical localization of laminin-1 in the acellular nerve grafts is associated with migrating Schwann cells which display corresponding integrin receptors. General Physiology and Biophysics. Bratislava: Veda, 1999, vol. 18, No 1, p. 63-65. ISSN 0231-5882. |
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@article{234931, author = {Dubový, Petr and Svíženská, Ivana and Jančálek, Radim and Klusáková, Ilona and Houšťava, Ladislav and Haninec, Pavel}, article_location = {Bratislava}, article_number = {1}, keywords = {Acellular nerve graft; Integrins; Laminin-1; Schwann cell migration}, language = {eng}, issn = {0231-5882}, journal = {General Physiology and Biophysics}, title = {Immunohistochemical localization of laminin-1 in the acellular nerve grafts is associated with migrating Schwann cells which display corresponding integrin receptors}, volume = {18}, year = {1999} }
TY - JOUR ID - 234931 AU - Dubový, Petr - Svíženská, Ivana - Jančálek, Radim - Klusáková, Ilona - Houšťava, Ladislav - Haninec, Pavel PY - 1999 TI - Immunohistochemical localization of laminin-1 in the acellular nerve grafts is associated with migrating Schwann cells which display corresponding integrin receptors JF - General Physiology and Biophysics VL - 18 IS - 1 SP - 63 EP - 63 PB - Veda SN - 02315882 KW - Acellular nerve graft KW - Integrins KW - Laminin-1 KW - Schwann cell migration N2 - The presence of laminin-1, collagen-IV, a6 and b1 integrin chains was detected by indirect immunohistochemistry using biotin/streptavidin/HRP or gold-conjugated secondary antibody at the light and electron microscope level, respectively. Cryo-treated segment of the peripheral stump without living Schwann cells (S-100-) did not display immunoreactivity for laminin-1 and integrin's chains, while the migrating Schwann cells in the marginal regions were immunostained for the antigens. Isolated acellular nerve segments protected from migration of Schwann cells (S-100-) exhibited laminin-l-, b1-, and a6- integrin chains immunoreactivities. Position of the basal lamina was verified by collagen-IV+ immunoreactivity. Results indicate that presence of the laminin in the peripheral nerve is related with living Schwann cells. ER -
DUBOVÝ, Petr, Ivana SVÍŽENSKÁ, Radim JANČÁLEK, Ilona KLUSÁKOVÁ, Ladislav HOUŠŤAVA and Pavel HANINEC. Immunohistochemical localization of laminin-1 in the acellular nerve grafts is associated with migrating Schwann cells which display corresponding integrin receptors. \textit{General Physiology and Biophysics}. Bratislava: Veda, 1999, vol.~18, No~1, p.~63-65. ISSN~0231-5882.
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