Structural conservation of antibiotic interaction with
ribosomes

J 2023

Structural conservation of antibiotic interaction with ribosomes

PATERNOGA, Helge; Caillan CROWE-MCAULIFFE; Lars V BOCK; Timm O KOLLER; Martino MORICI et. al.

Základní údaje

Originální název

Structural conservation of antibiotic interaction with ribosomes

Autoři

PATERNOGA, Helge; Caillan CROWE-MCAULIFFE; Lars V BOCK; Timm O KOLLER; Martino MORICI; Bertrand BECKERT; Alexander G MYASNIKOV; Helmut GRUBMUELLER; Jiří NOVÁČEK a Daniel N WILSON

Vydání

NATURE STRUCTURAL & MOLECULAR BIOLOGY, NEW YORK, NATURE PUBLISHING GROUP, 2023, 1545-9993

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 12.500

Kód RIV

RIV/00216224:14740/23:00133510

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1038/s41594-023-01047-y

UT WoS

001043691200001

EID Scopus

2-s2.0-85166908230

Klíčová slova anglicky

ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies

Štítky

CF CRYO, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 10. 2024 13:53, Ing. Martina Blahová

Anotace

V originále

Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.

Návaznosti

EF18_046/0015974, projekt VaV

Název: Modernizace České infrastruktury pro integrativní strukturní biologii

LM2023042, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CIISB - Česká infrastruktura pro integrativní strukturní biologii

871037, interní kód MU

Název: iNEXT-Discovery: Infrastructure for transnational access and discovery in integrated structural biology (Akronym: iNEXT- Discovery)

Investor: Evropská unie, iNEXT-Discovery: Infrastructure for transnational access and discovery in integrated structural biology, RI Research Infrastructures (Excellent Science)

Citovat

PATERNOGA, Helge; Caillan CROWE-MCAULIFFE; Lars V BOCK; Timm O KOLLER; Martino MORICI; Bertrand BECKERT; Alexander G MYASNIKOV; Helmut GRUBMUELLER; Jiří NOVÁČEK a Daniel N WILSON. Structural conservation of antibiotic interaction with ribosomes. NATURE STRUCTURAL & MOLECULAR BIOLOGY. NEW YORK: NATURE PUBLISHING GROUP, 2023, roč. 30, č. 9, s. 1380-1414. ISSN 1545-9993. Dostupné z: https://doi.org/10.1038/s41594-023-01047-y.

@article{2372337,
   author = {Paternoga, Helge and CroweandMcAuliffe, Caillan and Bock, Lars V and Koller, Timm O and Morici, Martino and Beckert, Bertrand and Myasnikov, Alexander G and Grubmueller, Helmut and Nováček, Jiří and Wilson, Daniel N},
   article_location = {NEW YORK},
   article_number = {9},
   doi = {https://doi.org/10.1038/s41594-023-01047-y},
   keywords = {ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies},
   language = {eng},
   issn = {1545-9993},
   journal = {NATURE STRUCTURAL & MOLECULAR BIOLOGY},
   title = {Structural conservation of antibiotic interaction with ribosomes},
   url = {https://www.nature.com/articles/s41594-023-01047-y},
   volume = {30},
   year = {2023}
}

TY  - JOUR
ID  - 2372337
AU  - Paternoga, Helge - Crowe-McAuliffe, Caillan - Bock, Lars V - Koller, Timm O - Morici, Martino - Beckert, Bertrand - Myasnikov, Alexander G - Grubmueller, Helmut - Nováček, Jiří - Wilson, Daniel N
PY  - 2023
TI  - Structural conservation of antibiotic interaction with ribosomes
JF  - NATURE STRUCTURAL & MOLECULAR BIOLOGY
VL  - 30
IS  - 9
SP  - 1380-1414
EP  - 1380-1414
PB  - NATURE PUBLISHING GROUP
SN  - 15459993
KW  - ribosome
KW  - antibiotics
KW  - CryoEM
KW  - antibiotic–ribosome interactions
KW  - RNA-targeting therapies
UR  - https://www.nature.com/articles/s41594-023-01047-y
N2  - Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.
ER  -

PATERNOGA, Helge; Caillan CROWE-MCAULIFFE; Lars V BOCK; Timm O KOLLER; Martino MORICI; Bertrand BECKERT; Alexander G MYASNIKOV; Helmut GRUBMUELLER; Jiří NOVÁČEK a Daniel N WILSON. Structural conservation of antibiotic interaction with ribosomes. \textit{NATURE STRUCTURAL \&{}amp; MOLECULAR BIOLOGY}. NEW YORK: NATURE PUBLISHING GROUP, 2023, roč.~30, č.~9, s.~1380-1414. ISSN~1545-9993. Dostupné z: https://doi.org/10.1038/s41594-023-01047-y.

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