The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a
Syphilis-Infected and Control Population in The Netherlands:
Can Differences in the Number of Self-Reported Sexual Contacts
Indicate Protection against Syphilis?

J 2024

The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis?

VRBOVÁ, Eliška; Helene ZONDAG; Sylvia BRUISTEN a David ŠMAJS

Základní údaje

Originální název

The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis?

Autoři

VRBOVÁ, Eliška; Helene ZONDAG; Sylvia BRUISTEN a David ŠMAJS

Vydání

Venerology, Basel, MDPI, 2024, 2674-0710

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00135548

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.3390/venereology3010003

Klíčová slova anglicky

TLR2; syphilis infection; Treponema pallidum ssp. pallidum; Arg753Gln polymorphisms; role of TLR2 in syphilis infection

Štítky

NIVB_LF, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 2. 2024 08:34, Mgr. Tereza Miškechová

Anotace

V originále

The Arg753Gln polymorphism in Toll-like receptor 2 has been associated with an increased risk of bacterial infections as well as with protection from the late stages of Lyme disease and the acquisition of syphilis. In this study, we determined the presence of this polymorphism in samples collected from men having sex with men/men with women in the Amsterdam Cohort Studies. The presence of the polymorphism was determined by nested PCR, followed by Sanger sequencing. A set of 90 syphilis-seronegative individuals was compared to 95 syphilis-diagnosed participants. A polymorphism allele frequency of 3.9% was found in the control group and 2.63% in the syphilis case group, respectively. None of the individuals showed a homozygous Arg753Gln polymorphism. The number of self-reported sexual contacts was higher in the group of syphilis patients compared to the control group (p = 0.0063). Moreover, in the syphilis case group (n = 49), participants heterozygous for the TLR2-Arg753Gln reported higher numbers of sexual contacts (p = 0.037) compared to wild-type homozygotes. Our findings suggest a possible protective effect of TLR2-Arg753Gln in the acquisition of syphilis. In addition, the determination of the number of self-reported sexual contacts can be used in an evaluation of the protective effect of polymorphism in a population with a low prevalence of it.

Návaznosti

LX22NPO5103, projekt VaV

Název: Národní institut virologie a bakteriologie (Akronym: NIVB)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut virologie a bakteriologie, 5.1 EXCELES

Přiložené soubory

The_Arg753Gln_Polymorphisms_in_Toll-like_Receptor_2_in_a_Syphilis-Infected_and_Control_Population_in_The_Netherlands_Can_Differences_in_the_Number_of_Self-Reported_Sexual_Contacts_Indicate_Protection_against_Syphilis.pdf

Citovat

VRBOVÁ, Eliška; Helene ZONDAG; Sylvia BRUISTEN a David ŠMAJS. The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis? Venerology. Basel: MDPI, 2024, roč. 3, č. 1, s. 1-9. ISSN 2674-0710. Dostupné z: https://doi.org/10.3390/venereology3010003.

@article{2376657,
   author = {Vrbová, Eliška and Zondag, Helene and Bruisten, Sylvia and Šmajs, David},
   article_location = {Basel},
   article_number = {1},
   doi = {https://doi.org/10.3390/venereology3010003},
   keywords = {TLR2; syphilis infection; Treponema pallidum ssp. pallidum; Arg753Gln polymorphisms; role of TLR2 in syphilis infection},
   language = {eng},
   issn = {2674-0710},
   journal = {Venerology},
   title = {The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis?},
   url = {https://www.mdpi.com/2674-0710/3/1/3},
   volume = {3},
   year = {2024}
}

TY  - JOUR
ID  - 2376657
AU  - Vrbová, Eliška - Zondag, Helene - Bruisten, Sylvia - Šmajs, David
PY  - 2024
TI  - The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis?
JF  - Venerology
VL  - 3
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - MDPI
SN  - 26740710
KW  - TLR2
KW  - syphilis infection
KW  - Treponema pallidum ssp. pallidum
KW  - Arg753Gln polymorphisms
KW  - role of TLR2 in syphilis infection
UR  - https://www.mdpi.com/2674-0710/3/1/3
N2  - The Arg753Gln polymorphism in Toll-like receptor 2 has been associated with an increased risk of bacterial infections as well as with protection from the late stages of Lyme disease and the acquisition of syphilis. In this study, we determined the presence of this polymorphism in samples collected from men having sex with men/men with women in the Amsterdam Cohort Studies. The presence of the polymorphism was determined by nested PCR, followed by Sanger sequencing. A set of 90 syphilis-seronegative individuals was compared to 95 syphilis-diagnosed participants. A polymorphism allele frequency of 3.9% was found in the control group and 2.63% in the syphilis case group, respectively. None of the individuals showed a homozygous Arg753Gln polymorphism. The number of self-reported sexual contacts was higher in the group of syphilis patients compared to the control group (p = 0.0063). Moreover, in the syphilis case group (n = 49), participants heterozygous for the TLR2-Arg753Gln reported higher numbers of sexual contacts (p = 0.037) compared to wild-type homozygotes. Our findings suggest a possible protective effect of TLR2-Arg753Gln in the acquisition of syphilis. In addition, the determination of the number of self-reported sexual contacts can be used in an evaluation of the protective effect of polymorphism in a population with a low prevalence of it.
ER  -

VRBOVÁ, Eliška; Helene ZONDAG; Sylvia BRUISTEN a David ŠMAJS. The Arg753Gln Polymorphisms in Toll-like Receptor 2 in a Syphilis-Infected and Control Population in The Netherlands: Can Differences in the Number of Self-Reported Sexual Contacts Indicate Protection against Syphilis? \textit{Venerology}. Basel: MDPI, 2024, roč.~3, č.~1, s.~1-9. ISSN~2674-0710. Dostupné z: https://doi.org/10.3390/venereology3010003.

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