Emergency medicine pharmacotherapy compromises accuracy of
plasma creatinine determination by enzyme-based methods:
real-world clinical evidence and implications for clinical
practice

J 2024

Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice

DEMLOVÁ, Regina; Šárka KOZÁKOVÁ; Michal ŘIHÁČEK; Dana BUČKOVÁ; Kateřina HORSKÁ et al.

Základní údaje

Originální název

Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice

Autoři

Vydání

Frontiers in Medicine, Laussane, Frontiers, 2024, 2296-858X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.000

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00135556

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

creatinine; renal functions; eGFR; urgent care medication; cystatin C

Štítky

14110317, 14110516, 14110616, 14311010

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 1. 2025 13:14, Mgr. Tereza Miškechová

Anotace

V originále

Background: Assessment of kidney function in emergency settings is essential across all medical subspecialties. Daily assessment of patient creatinine results from emergency medical services showed that some deviated from expected values, implying drug-related interference. Methods: Real-time clinical evaluation of an enzyme method (Roche CREP2) in comparison with the Jaffe gen. 2 method (Roche CREJ2) was performed. During the period of December 2022 and January 2023, we analyzed 8,498 patient samples, where 5,524 were heavily medicated STAT patient specimens, 500 were pediatric specimens, and 2,474 were from a distant general population in a different region using the same methods. Results: In 109 out of 5,524 hospital specimens (1.97%, p < 0.001), the CREP2 value was apparently (25% or more) lower than CREJ2. Suspect interfering medication was found in a sample of 43 out of 46 reviewed patients where medication data were available. This phenomenon was not observed in the general population. Conclusion: In a polymedicated urgent care hospital population, a creatinine enzyme method produces unreliable results, apparently due to multiple drug-related interferences.

Návaznosti

CZ.02.1.01/0.0/0.0/16_013/0001826, interní kód MU
(Kód CEP: EF16_013/0001826)

Název: CZECRIN_PRO PACIENTY - zavádění inovativních moderních terapií

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CZECRIN_PRO PACIENTY - zavádění inovativních moderních terapií, PO 1 Posilování kapacit pro kvalitní výzkum

LM2023049, projekt VaV

Název: Český národní uzel Evropské sítě infrastruktur klinického výzkumu

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CZECRIN - Czech National Node to the European Clinical Research Infrastructure Network

101059788, interní kód MU

Název: Central European Advanced Therapy and Immunotherapy Centre

Investor: Evropská unie, Central European Advanced Therapy and Immunotherapy Centre, Rozšiřování účasti a posílení ERA

Citovat

DEMLOVÁ, Regina; Šárka KOZÁKOVÁ; Michal ŘIHÁČEK; Dana BUČKOVÁ; Kateřina HORSKÁ; Ondřej WIEWIORKA; Luboš BOUČEK; Iveta SELINGEROVÁ; Martina PODBORSKÁ; Alena KORBEROVÁ; Alena MIKUŠKOVÁ; Jiří ŠTARHA; Miroslava BEŇOVSKÁ; Martin RADINA; Michal RICHTER; Lenka ZDRAŽILOVÁ DUBSKÁ a Dalibor VALÍK. Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice. Frontiers in Medicine. Laussane: Frontiers, 2024, roč. 10, January 2024, s. 1-16. ISSN 2296-858X. Dostupné z: https://doi.org/10.3389/fmed.2023.1236948.

@article{2377086,
   author = {Demlová, Regina and Kozáková, Šárka and Řiháček, Michal and Bučková, Dana and Horská, Kateřina and Wiewiorka, Ondřej and Bouček, Luboš and Selingerová, Iveta and Podborská, Martina and Korberová, Alena and Mikušková, Alena and Štarha, Jiří and Beňovská, Miroslava and Radina, Martin and Richter, Michal and Zdražilová Dubská, Lenka and Valík, Dalibor},
   article_location = {Laussane},
   article_number = {January 2024},
   doi = {https://doi.org/10.3389/fmed.2023.1236948},
   keywords = {creatinine; renal functions; eGFR; urgent care medication; cystatin C},
   language = {eng},
   issn = {2296-858X},
   journal = {Frontiers in Medicine},
   title = {Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice},
   url = {https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1236948/full},
   volume = {10},
   year = {2024}
}

TY  - JOUR
ID  - 2377086
AU  - Demlová, Regina - Kozáková, Šárka - Řiháček, Michal - Bučková, Dana - Horská, Kateřina - Wiewiorka, Ondřej - Bouček, Luboš - Selingerová, Iveta - Podborská, Martina - Korberová, Alena - Mikušková, Alena - Štarha, Jiří - Beňovská, Miroslava - Radina, Martin - Richter, Michal - Zdražilová Dubská, Lenka - Valík, Dalibor
PY  - 2024
TI  - Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice
JF  - Frontiers in Medicine
VL  - 10
IS  - January 2024
SP  - 1-16
EP  - 1-16
PB  - Frontiers
SN  - 2296858X
KW  - creatinine
KW  - renal functions
KW  - eGFR
KW  - urgent care medication
KW  - cystatin C
UR  - https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1236948/full
N2  - Background: Assessment of kidney function in emergency settings is essential across all medical subspecialties. Daily assessment of patient creatinine results from emergency medical services showed that some deviated from expected values, implying drug-related interference. Methods: Real-time clinical evaluation of an enzyme method (Roche CREP2) in comparison with the Jaffe gen. 2 method (Roche CREJ2) was performed. During the period of December 2022 and January 2023, we analyzed 8,498 patient samples, where 5,524 were heavily medicated STAT patient specimens, 500 were pediatric specimens, and 2,474 were from a distant general population in a different region using the same methods. Results: In 109 out of 5,524 hospital specimens (1.97%, p < 0.001), the CREP2 value was apparently (25% or more) lower than CREJ2. Suspect interfering medication was found in a sample of 43 out of 46 reviewed patients where medication data were available. This phenomenon was not observed in the general population. Conclusion: In a polymedicated urgent care hospital population, a creatinine enzyme method produces unreliable results, apparently due to multiple drug-related interferences.
ER  -

DEMLOVÁ, Regina; Šárka KOZÁKOVÁ; Michal ŘIHÁČEK; Dana BUČKOVÁ; Kateřina HORSKÁ; Ondřej WIEWIORKA; Luboš BOUČEK; Iveta SELINGEROVÁ; Martina PODBORSKÁ; Alena KORBEROVÁ; Alena MIKUŠKOVÁ; Jiří ŠTARHA; Miroslava BEŇOVSKÁ; Martin RADINA; Michal RICHTER; Lenka ZDRAŽILOVÁ DUBSKÁ a Dalibor VALÍK. Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice. \textit{Frontiers in Medicine}. Laussane: Frontiers, 2024, roč.~10, January 2024, s.~1-16. ISSN~2296-858X. Dostupné z: https://doi.org/10.3389/fmed.2023.1236948.

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