Hippocampal subfield volumetric changes after radiotherapy for
brain metastases

J 2024

Hippocampal subfield volumetric changes after radiotherapy for brain metastases

HOLÍKOVÁ, Klára; Iveta SELINGEROVÁ; Petr POSPÍŠIL; Martin BULIK; Ludmila HYNKOVÁ et al.

Základní údaje

Originální název

Hippocampal subfield volumetric changes after radiotherapy for brain metastases

Autoři

Vydání

NEURO-ONCOLOGY ADVANCES, OXFORD, OXFORD UNIV PRESS, 2024, 2632-2498

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.100

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00135961

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

brain; hippocampus; metastasis; radiotherapy; volumetry

Štítky

14110119, 14110131, 14110811, 14110812, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 6. 2025 08:27, Mgr. Tereza Miškechová

Anotace

V originále

Background Changes in the hippocampus after brain metastases radiotherapy can significantly impact neurocognitive functions. Numerous studies document hippocampal atrophy correlating with the radiation dose. This study aims to elucidate volumetric changes in patients undergoing whole-brain radiotherapy (WBRT) or targeted stereotactic radiotherapy (SRT) and to explore volumetric changes in the individual subregions of the hippocampus.Method Ten patients indicated to WBRT and 18 to SRT underwent brain magnetic resonance before radiotherapy and after 4 months. A structural T1-weighted sequence was used for volumetric analysis, and the software FreeSurfer was employed as the tool for the volumetry evaluation of 19 individual hippocampal subregions.Results The volume of the whole hippocampus, segmented by the software, was larger than the volume outlined by the radiation oncologist. No significant differences in volume changes were observed in the right hippocampus. In the left hippocampus, the only subregion with a smaller volume after WBRT was the granular cells and molecular layers of the dentate gyrus (GC-ML-DG) region (median change -5 mm3, median volume 137 vs. 135 mm3; P = .027), the region of the presumed location of neuronal progenitors.Conclusions Our study enriches the theory that the loss of neural stem cells is involved in cognitive decline after radiotherapy, contributes to the understanding of cognitive impairment, and advocates for the need for SRT whenever possible to preserve cognitive functions in patients undergoing brain radiotherapy.

Návaznosti

LX22NPO5102, projekt VaV

Název: Národní ústav pro výzkum rakoviny (Akronym: NÚVR)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro výzkum rakoviny, 5.1 EXCELES

NV18-03-00469, projekt VaV

Název: Reakce neuronální populace hipokampu na stereotaktickou radioterapii extratemporálních mozkových metastáz: vliv na neurokognitivní funkce a zachování kvality života

Investor: Ministerstvo zdravotnictví ČR, Reakce neuronální populace hipokampu na stereotaktickou radioterapii extratemporálních mozkových metastáz: vliv na neurokognitivní funkce a zachování kvality života

90233, velká výzkumná infrastruktura

Název: BBMRI.cz IV

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Přiložené soubory

Hippocampal_subfield_volumetric_changes_after_radiotherapy_for_brain_metastases.pdf

Citovat

HOLÍKOVÁ, Klára; Iveta SELINGEROVÁ; Petr POSPÍŠIL; Martin BULIK; Ludmila HYNKOVÁ; Ivana KOLOUŠKOVÁ; Lucie HNIDÁKOVÁ; Petr BURKOŇ; Marek SLÁVIK; Jiří ŠÁNA; Tomáš HOLEČEK; Jiří VANÍČEK; Pavel ŠLAMPA; Radim JANČÁLEK a Tomáš KAZDA. Hippocampal subfield volumetric changes after radiotherapy for brain metastases. NEURO-ONCOLOGY ADVANCES. OXFORD: OXFORD UNIV PRESS, 2024, roč. 6, č. 1, s. 1-9. ISSN 2632-2498. Dostupné z: https://doi.org/10.1093/noajnl/vdae040.

@article{2400177,
   author = {Holíková, Klára and Selingerová, Iveta and Pospíšil, Petr and Bulik, Martin and Hynková, Ludmila and Koloušková, Ivana and Hnidáková, Lucie and Burkoň, Petr and Slávik, Marek and Šána, Jiří and Holeček, Tomáš and Vaníček, Jiří and Šlampa, Pavel and Jančálek, Radim and Kazda, Tomáš},
   article_location = {OXFORD},
   article_number = {1},
   doi = {https://doi.org/10.1093/noajnl/vdae040},
   keywords = {brain; hippocampus; metastasis; radiotherapy; volumetry},
   language = {eng},
   issn = {2632-2498},
   journal = {NEURO-ONCOLOGY ADVANCES},
   title = {Hippocampal subfield volumetric changes after radiotherapy for brain metastases},
   url = {https://academic.oup.com/noa/article/6/1/vdae040/7632607?login=true},
   volume = {6},
   year = {2024}
}

TY  - JOUR
ID  - 2400177
AU  - Holíková, Klára - Selingerová, Iveta - Pospíšil, Petr - Bulik, Martin - Hynková, Ludmila - Koloušková, Ivana - Hnidáková, Lucie - Burkoň, Petr - Slávik, Marek - Šána, Jiří - Holeček, Tomáš - Vaníček, Jiří - Šlampa, Pavel - Jančálek, Radim - Kazda, Tomáš
PY  - 2024
TI  - Hippocampal subfield volumetric changes after radiotherapy for brain metastases
JF  - NEURO-ONCOLOGY ADVANCES
VL  - 6
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - OXFORD UNIV PRESS
SN  - 26322498
KW  - brain
KW  - hippocampus
KW  - metastasis
KW  - radiotherapy
KW  - volumetry
UR  - https://academic.oup.com/noa/article/6/1/vdae040/7632607?login=true
N2  - Background Changes in the hippocampus after brain metastases radiotherapy can significantly impact neurocognitive functions. Numerous studies document hippocampal atrophy correlating with the radiation dose. This study aims to elucidate volumetric changes in patients undergoing whole-brain radiotherapy (WBRT) or targeted stereotactic radiotherapy (SRT) and to explore volumetric changes in the individual subregions of the hippocampus.Method Ten patients indicated to WBRT and 18 to SRT underwent brain magnetic resonance before radiotherapy and after 4 months. A structural T1-weighted sequence was used for volumetric analysis, and the software FreeSurfer was employed as the tool for the volumetry evaluation of 19 individual hippocampal subregions.Results The volume of the whole hippocampus, segmented by the software, was larger than the volume outlined by the radiation oncologist. No significant differences in volume changes were observed in the right hippocampus. In the left hippocampus, the only subregion with a smaller volume after WBRT was the granular cells and molecular layers of the dentate gyrus (GC-ML-DG) region (median change -5 mm3, median volume 137 vs. 135 mm3; P = .027), the region of the presumed location of neuronal progenitors.Conclusions Our study enriches the theory that the loss of neural stem cells is involved in cognitive decline after radiotherapy, contributes to the understanding of cognitive impairment, and advocates for the need for SRT whenever possible to preserve cognitive functions in patients undergoing brain radiotherapy.
ER  -

HOLÍKOVÁ, Klára; Iveta SELINGEROVÁ; Petr POSPÍŠIL; Martin BULIK; Ludmila HYNKOVÁ; Ivana KOLOUŠKOVÁ; Lucie HNIDÁKOVÁ; Petr BURKOŇ; Marek SLÁVIK; Jiří ŠÁNA; Tomáš HOLEČEK; Jiří VANÍČEK; Pavel ŠLAMPA; Radim JANČÁLEK a Tomáš KAZDA. Hippocampal subfield volumetric changes after radiotherapy for brain metastases. \textit{NEURO-ONCOLOGY ADVANCES}. OXFORD: OXFORD UNIV PRESS, 2024, roč.~6, č.~1, s.~1-9. ISSN~2632-2498. Dostupné z: https://doi.org/10.1093/noajnl/vdae040.

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