Impact of the International Tumor Budding Consensus Conference
Recommendations in Oral Cancer

J 2025

Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer

KOPECKA, Katerina; Michal HERMAN; Jaroslav MICHALEK; Jana ZAPLETALOVA; Markéta HERMANOVÁ et al.

Základní údaje

Originální název

Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer

Autoři

KOPECKA, Katerina; Michal HERMAN; Jaroslav MICHALEK; Jana ZAPLETALOVA; Markéta HERMANOVÁ; Priska LIPTÁKOVÁ; Michal HENDRYCH; Michal MOZOLA a Richard PINK

Vydání

Oral diseases, Hoboken, Wiley, 2025, 1354-523X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140542

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

histopathology; oral squamous cell carcinoma; prognosis; tumor budding

Štítky

14110112, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 10. 2025 13:48, Mgr. Tereza Miškechová

Anotace

V originále

ObjectivesTumor budding was suggested as a valuable prognostic factor in oral squamous cell carcinoma (OSCC) but lacks a standardized scoring system. This study evaluates tumor budding in OSCC using the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.Materials and MethodsThe study included 114 patients with resected OSCC. Tumor budding was evaluated according to ITBCC criteria and assigned to three categories (low, intermediate, and high tumor budding). The associations between tumor budding and clinicopathological parameters were examined and survival rate analyses were performed by the Kaplan-Meier method. The prognostic value of tumor budding was assessed by Cox regression analysis.ResultsSignificant correlations of tumor budding with clinicopathological parameters including lymph node metastasis, grade, stage, perineural and lymphovascular invasion, and local recurrence were found. Intermediate and high tumor budding were significantly and independently associated with worse disease-free survival. High tumor budding was identified as an independent prognostic factor for disease-specific and overall survival.ConclusionsThe ITBCC scoring system represents a simple, feasible, and reproducible method to evaluate tumor budding in OSCC. Tumor budding, according to ITBCC criteria, showed its prognostic value in resected OSCC, and its incorporation into the histopathological reporting guidelines should be considered.

Citovat

KOPECKA, Katerina; Michal HERMAN; Jaroslav MICHALEK; Jana ZAPLETALOVA; Markéta HERMANOVÁ; Priska LIPTÁKOVÁ; Michal HENDRYCH; Michal MOZOLA a Richard PINK. Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer. Oral diseases. Hoboken: Wiley, 2025, roč. 31, č. 7, s. 2119-2128. ISSN 1354-523X. Dostupné z: https://doi.org/10.1111/odi.15215.

@article{2470299,
   author = {Kopecka, Katerina and Herman, Michal and Michalek, Jaroslav and Zapletalova, Jana and Hermanová, Markéta and Liptáková, Priska and Hendrych, Michal and Mozola, Michal and Pink, Richard},
   article_location = {Hoboken},
   article_number = {7},
   doi = {https://doi.org/10.1111/odi.15215},
   keywords = {histopathology; oral squamous cell carcinoma; prognosis; tumor budding},
   language = {eng},
   issn = {1354-523X},
   journal = {Oral diseases},
   title = {Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/odi.15215},
   volume = {31},
   year = {2025}
}

TY  - JOUR
ID  - 2470299
AU  - Kopecka, Katerina - Herman, Michal - Michalek, Jaroslav - Zapletalova, Jana - Hermanová, Markéta - Liptáková, Priska - Hendrych, Michal - Mozola, Michal - Pink, Richard
PY  - 2025
TI  - Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer
JF  - Oral diseases
VL  - 31
IS  - 7
SP  - 2119-2128
EP  - 2119-2128
PB  - Wiley
SN  - 1354523X
KW  - histopathology
KW  - oral squamous cell carcinoma
KW  - prognosis
KW  - tumor budding
UR  - https://onlinelibrary.wiley.com/doi/10.1111/odi.15215
N2  - ObjectivesTumor budding was suggested as a valuable prognostic factor in oral squamous cell carcinoma (OSCC) but lacks a standardized scoring system. This study evaluates tumor budding in OSCC using the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.Materials and MethodsThe study included 114 patients with resected OSCC. Tumor budding was evaluated according to ITBCC criteria and assigned to three categories (low, intermediate, and high tumor budding). The associations between tumor budding and clinicopathological parameters were examined and survival rate analyses were performed by the Kaplan-Meier method. The prognostic value of tumor budding was assessed by Cox regression analysis.ResultsSignificant correlations of tumor budding with clinicopathological parameters including lymph node metastasis, grade, stage, perineural and lymphovascular invasion, and local recurrence were found. Intermediate and high tumor budding were significantly and independently associated with worse disease-free survival. High tumor budding was identified as an independent prognostic factor for disease-specific and overall survival.ConclusionsThe ITBCC scoring system represents a simple, feasible, and reproducible method to evaluate tumor budding in OSCC. Tumor budding, according to ITBCC criteria, showed its prognostic value in resected OSCC, and its incorporation into the histopathological reporting guidelines should be considered.
ER  -

KOPECKA, Katerina; Michal HERMAN; Jaroslav MICHALEK; Jana ZAPLETALOVA; Markéta HERMANOVÁ; Priska LIPTÁKOVÁ; Michal HENDRYCH; Michal MOZOLA a Richard PINK. Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer. \textit{Oral diseases}. Hoboken: Wiley, 2025, roč.~31, č.~7, s.~2119-2128. ISSN~1354-523X. Dostupné z: https://doi.org/10.1111/odi.15215.

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