EEG Signature of neurodegeneration-associated proteins in the
drug-resistant MTLE

a 2024

EEG Signature of neurodegeneration-associated proteins in the drug-resistant MTLE

ZATLOUKALOVÁ, Eva; Iveta ŠEVČÍKOVÁ; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; B. MATOUŠKOVÁ et al.

Základní údaje

Originální název

EEG Signature of neurodegeneration-associated proteins in the drug-resistant MTLE

Autoři

ZATLOUKALOVÁ, Eva; Iveta ŠEVČÍKOVÁ; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; B. MATOUŠKOVÁ; Petr KLIMEŠ; Markéta HERMANOVÁ a Milan BRÁZDIL

Vydání

36. ČESKÝ A SLOVENSKÝ EPILEPTOLOGICKÝ SJEZD, 2024

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30210 Clinical neurology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00138605

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

neurodegeneration-associated proteins; EEG Signature; drug-resistant MTLE

Změněno: 4. 4. 2025 14:20, Mgr. Tereza Miškechová

Anotace

V originále

A growing body of evidence shows a significant role of the neurodegeneration processes in drug-resistant epilepsy. Beta-amyloid, hyperphosphorylated tau, alpha-synuclein, and TDP-43 are called neurodegenerative-associated proteins (NAPs), and their pathologic aggregates are traditional hallmarks of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Both animal and human studies show increased levels of NAPs in the brains of the patients suffering from drug-resistant epilepsy of the temporal lobe (MTLE) compared to the age-matched population. The influence of the NAPs on brain electrophysiology is yet to be unraveled. In the current study, thirty patients from the two comprehensive epilepsy centers suffering from drug-resistant MTLE who underwent presurgical stereo- EEG (SEEG) monitoring and the anteromesial temporal resection were included. The tissue was immunohistochemically examined for the presence of pathological aggregates of NAPs. Interictal SEEG was analyzed for selected electrophysiological features (spikes, HFOs, and connectivity measures). Correlation between the electrophysiological measures and NAPs burden was made to ascertain the neurodegeneration signature in the EEG.

Návaznosti

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

NU22-04-00366, projekt VaV

Název: Role neurodegenerace v patogenezi, manifestaci a prognóze MTLE/HS - in vivo, ex vivo a in vitro perspektiva

Investor: Ministerstvo zdravotnictví ČR, Role neurodegenerace v patogenezi, manifestaci a prognóze MTLE/HS - in vivo, ex vivo a in vitro perspektiva, Podprogram 1 - standardní

Citovat

ZATLOUKALOVÁ, Eva; Iveta ŠEVČÍKOVÁ; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; B. MATOUŠKOVÁ; Petr KLIMEŠ; Markéta HERMANOVÁ a Milan BRÁZDIL. EEG Signature of neurodegeneration-associated proteins in the drug-resistant MTLE. In 36. ČESKÝ A SLOVENSKÝ EPILEPTOLOGICKÝ SJEZD. 2024.

@proceedings{2470608,
   author = {Zatloukalová, Eva and Ševčíková, Iveta and Hendrych, Michal and Dvořáková, Sylva and Matoušková, B. and Klimeš, Petr and Hermanová, Markéta and Brázdil, Milan},
   booktitle = {36. ČESKÝ A SLOVENSKÝ EPILEPTOLOGICKÝ SJEZD},
   keywords = {neurodegeneration-associated proteins; EEG Signature; drug-resistant MTLE},
   language = {eng},
   title = {EEG Signature of neurodegeneration-associated proteins in the drug-resistant MTLE},
   year = {2024}
}

TY  - CONF
ID  - 2470608
AU  - Zatloukalová, Eva - Ševčíková, Iveta - Hendrych, Michal - Dvořáková, Sylva - Matoušková, B. - Klimeš, Petr - Hermanová, Markéta - Brázdil, Milan
PY  - 2024
TI  - EEG Signature of neurodegeneration-associated proteins in the drug-resistant MTLE
KW  - neurodegeneration-associated proteins
KW  - EEG Signature
KW  - drug-resistant MTLE
N2  - A growing body of evidence shows a significant role of the neurodegeneration processes in drug-resistant epilepsy. Beta-amyloid, hyperphosphorylated tau, alpha-synuclein, and TDP-43 are called neurodegenerative-associated proteins (NAPs), and their pathologic aggregates are traditional hallmarks of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Both animal and human studies show increased levels of NAPs in the brains of the patients suffering from drug-resistant epilepsy of the temporal lobe (MTLE) compared to the age-matched population. The influence of the NAPs on brain electrophysiology is yet to be unraveled. In the current study, thirty patients from the two comprehensive epilepsy centers suffering from drug-resistant MTLE who underwent presurgical stereo- EEG (SEEG) monitoring and the anteromesial temporal resection were included. The tissue was immunohistochemically examined for the presence of pathological aggregates of NAPs. Interictal SEEG was analyzed for selected electrophysiological features (spikes, HFOs, and connectivity measures). Correlation between the electrophysiological measures and NAPs burden was made to ascertain the neurodegeneration signature in the EEG.
ER  -

ZATLOUKALOVÁ, Eva; Iveta ŠEVČÍKOVÁ; Michal HENDRYCH; Sylva DVOŘÁKOVÁ; B. MATOUŠKOVÁ; Petr KLIMEŠ; Markéta HERMANOVÁ a Milan BRÁZDIL. EEG Signature of neurodegeneration-associated proteins in the drug-resistant MTLE. In \textit{36. ČESKÝ A SLOVENSKÝ EPILEPTOLOGICKÝ SJEZD}. 2024.

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