HUMAN EMBRYONIC STEM CELL-BASED NEURAL DEVELOPMENTAL MODELING
REVEALS THE VERSATILE ROLES OF FGF2 SIGNALING

a 2016

HUMAN EMBRYONIC STEM CELL-BASED NEURAL DEVELOPMENTAL MODELING REVEALS THE VERSATILE ROLES OF FGF2 SIGNALING

GRABIEC, Marta; Hana HŘÍBKOVÁ; Miroslav VAŘECHA; Petr DVOŘÁK; Yuh-Man WADELEY et al.

Základní údaje

Originální název

HUMAN EMBRYONIC STEM CELL-BASED NEURAL DEVELOPMENTAL MODELING REVEALS THE VERSATILE ROLES OF FGF2 SIGNALING

Autoři

GRABIEC, Marta; Hana HŘÍBKOVÁ ; Miroslav VAŘECHA; Petr DVOŘÁK a Yuh-Man WADELEY

Vydání

ISSCR 2016 Dresden Symposium, 2016

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Human Embryonic Stem Cells (hESC), Neural Stem Cells (NSC), neural rosettes, Fibroblast Growth Factor 2 (FGF2)

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 2. 2025 08:54, Mgr. Kamila Ježová

Anotace

V originále

The invention of human embryonic stem cell (hESC) and induced pluripotent stem cell (hiPSC) technologies have shifted the research approach from the adaptation of conventional animal models to the human pluripotent stem cell (hPSC)-based modeling, which offers potential for studying human conditions using human systems. However, despite hPSCs holding great potential, it is imperative to validate how faithful hPSC-based neural developmental modeling is in recapitulating the developmental process in vivo. This study undertook to substantiate the validity of hPSC-based neural developmental modeling by comparing it with many facets of neural developmental events occurring in mice. We found that the hPSC-based system mimicked the process from the neural plate to the neural tube, then to the neocortex, during which the system captured characteristics of brain development. We also showed that the system reserved the similar neural stem cell (NSC) niche residing in the ventricular region of the cortex. Moreover, FGF2 signaling exhibited a different repertoire of regulatory activities depending upon neural stage progression.

Citovat

GRABIEC, Marta; Hana HŘÍBKOVÁ; Miroslav VAŘECHA; Petr DVOŘÁK a Yuh-Man WADELEY. HUMAN EMBRYONIC STEM CELL-BASED NEURAL DEVELOPMENTAL MODELING REVEALS THE VERSATILE ROLES OF FGF2 SIGNALING. In ISSCR 2016 Dresden Symposium. 2016.

@proceedings{2477120,
   author = {Grabiec, Marta and Hříbková, Hana and Vařecha, Miroslav and Dvořák, Petr and Wadeley, YuhandMan},
   booktitle = {ISSCR 2016 Dresden Symposium},
   keywords = {Human Embryonic Stem Cells (hESC), Neural Stem Cells (NSC), neural rosettes, Fibroblast Growth Factor 2 (FGF2)},
   language = {eng},
   title = {HUMAN EMBRYONIC STEM CELL-BASED NEURAL DEVELOPMENTAL MODELING REVEALS THE VERSATILE ROLES OF FGF2 SIGNALING},
   url = {https://www.isscr.org/the-archives/#PastIS},
   year = {2016}
}

TY  - CONF
ID  - 2477120
AU  - Grabiec, Marta - Hříbková, Hana - Vařecha, Miroslav - Dvořák, Petr - Wadeley, Yuh-Man
PY  - 2016
TI  - HUMAN EMBRYONIC STEM CELL-BASED NEURAL DEVELOPMENTAL MODELING REVEALS THE VERSATILE ROLES OF FGF2 SIGNALING
KW  - Human Embryonic Stem Cells (hESC), Neural Stem Cells (NSC), neural rosettes, Fibroblast Growth Factor 2 (FGF2)
UR  - https://www.isscr.org/the-archives/#PastIS
N2  - The invention of human embryonic stem cell (hESC) and induced pluripotent stem cell (hiPSC) technologies have shifted the research approach from the adaptation of conventional animal models to the human pluripotent stem cell (hPSC)-based modeling, which offers potential for studying human conditions using human systems. However, despite hPSCs holding great potential, it is imperative to validate how faithful hPSC-based neural developmental modeling is in recapitulating the developmental process in vivo. This study undertook to substantiate the validity of hPSC-based neural developmental modeling by comparing it with many facets of neural developmental events occurring in mice. We found that the hPSC-based system mimicked the process from the neural plate to the neural tube, then to the neocortex, during which the system captured characteristics of brain development. We also showed that the system reserved the similar neural stem cell (NSC) niche residing in the ventricular region of the cortex. Moreover, FGF2 signaling exhibited a different repertoire of regulatory activities depending upon neural stage progression.
ER  -

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