PO-04-037 A PROSPECTIVE RANDOMIZED CLINICAL COMPARISON OF
CATHETER ABLATION OF ATRIAL FIBRILLATION USING THE CENTAURI PEF
SYSTEM, FARAPULSE SYSTEM, AND STANDARD RADIOFREQUENCY CATHETER
ABLATION

a 2025

PO-04-037 A PROSPECTIVE RANDOMIZED CLINICAL COMPARISON OF CATHETER ABLATION OF ATRIAL FIBRILLATION USING THE CENTAURI PEF SYSTEM, FARAPULSE SYSTEM, AND STANDARD RADIOFREQUENCY CATHETER ABLATION

STÁREK, Zdeněk; Filip SOUČEK; Katarína DOLEŽALOVÁ; Martin PEŠL; Vojtěch ŠEBETOVSKÝ et al.

Základní údaje

Originální název

PO-04-037 A PROSPECTIVE RANDOMIZED CLINICAL COMPARISON OF CATHETER ABLATION OF ATRIAL FIBRILLATION USING THE CENTAURI PEF SYSTEM, FARAPULSE SYSTEM, AND STANDARD RADIOFREQUENCY CATHETER ABLATION

Autoři

STÁREK, Zdeněk; Filip SOUČEK; Katarína DOLEŽALOVÁ; Martin PEŠL; Vojtěch ŠEBETOVSKÝ; Jakub HEJČ a Jan KREJČÍ

Vydání

2025

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.hrthm.2025.03.1172

Klíčová slova anglicky

Arrhythmia;Electrophysiology;Ablation;Cardiac;Pulse electric field

Změněno: 25. 3. 2026 14:45, Mgr. Tereza Miškechová

Anotace

V originále

ackground Irreversible electroporation (pulse field ablation, PFA) is a promising alternative of the radiofrequency (RF) energy in catheter ablation of atrial fibrillation (AF). Objective The aim of this study is to present one-year results comparing efficacy and safety of catheter ablation for AF using CENTAURI PEF System (CardioFocus Inc.), FARAPULSE System (Boston Scientific), and standard RF ablation. Methods Patients referred for ablation of AF (paroxysmal and persistent) were enrolled in this study and randomly assigned to one of the three groups mentioned above. RF and CENTAURI group underwent ablation using the EnSite Precision 3D mapping system and TactiCath CF ablation catheter (Abbott) with point-to-point ablation using PFA (CENTAURI) or RF energy (RF group). FARAPULSE group underwent ablation with a specialized single-shot multipolar basket catheter under X-ray and intracardiac ultrasound Results Between May 2023 and November 2024, 265 patients underwent catheter ablation for AF (159 parox. AF, 106 pers. AF). The baseline characteristics of the groups were similar. Periprocedural results - see Table. Complications - CENTAURI and RF groups had no complications, FARAPULSE group had one stroke and one tamponade. 12-month follow up - CENTAURI, 29 pts, 72% in sinus rhythm; RF, 10 pts, 60% sinus rhythm; FARAPULSE, no follow-up visits. When analyzing both paroxysmal and persistent AF cases, Conclusion Ablation with all systems appears to be comparably effective and safe. FARAPULSE results in shortest procedure time but highest X-ray dose. CENTAURI tends to shorter procedure time and faster ipsilateral pulmonary vein isolation compared to standard RF ablation. Complications in the FARAPULSE group may be attributed to the learning curve. Long-term effectiveness is limited by the small number of patients with follow-up data.

Návaznosti

MUNI/A/1624/2023, interní kód MU

Název: Srdeční selhání, jeho komorbidity a etiologické příčiny

Investor: Masarykova univerzita, Srdeční selhání, jeho komorbidity a etiologické příčiny

Citovat

STÁREK, Zdeněk; Filip SOUČEK; Katarína DOLEŽALOVÁ; Martin PEŠL; Vojtěch ŠEBETOVSKÝ; Jakub HEJČ a Jan KREJČÍ. PO-04-037 A PROSPECTIVE RANDOMIZED CLINICAL COMPARISON OF CATHETER ABLATION OF ATRIAL FIBRILLATION USING THE CENTAURI PEF SYSTEM, FARAPULSE SYSTEM, AND STANDARD RADIOFREQUENCY CATHETER ABLATION. 2025. Dostupné z: https://doi.org/10.1016/j.hrthm.2025.03.1172.

@proceedings{2498320,
   author = {Stárek, Zdeněk and Souček, Filip and Doležalová, Katarína and Pešl, Martin and Šebetovský, Vojtěch and Hejč, Jakub and Krejčí, Jan},
   doi = {https://doi.org/10.1016/j.hrthm.2025.03.1172},
   keywords = {Arrhythmia;Electrophysiology;Ablation;Cardiac;Pulse electric field},
   language = {eng},
   title = {PO-04-037 A PROSPECTIVE RANDOMIZED CLINICAL COMPARISON OF CATHETER ABLATION OF ATRIAL FIBRILLATION USING THE CENTAURI PEF SYSTEM, FARAPULSE SYSTEM, AND STANDARD RADIOFREQUENCY CATHETER ABLATION},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S1547527125013931},
   year = {2025}
}

TY  - CONF
ID  - 2498320
AU  - Stárek, Zdeněk - Souček, Filip - Doležalová, Katarína - Pešl, Martin - Šebetovský, Vojtěch - Hejč, Jakub - Krejčí, Jan
PY  - 2025
TI  - PO-04-037 A PROSPECTIVE RANDOMIZED CLINICAL COMPARISON OF CATHETER ABLATION OF ATRIAL FIBRILLATION USING THE CENTAURI PEF SYSTEM, FARAPULSE SYSTEM, AND STANDARD RADIOFREQUENCY CATHETER ABLATION
KW  - Arrhythmia;Electrophysiology;Ablation;Cardiac;Pulse electric field
UR  - https://www.sciencedirect.com/science/article/abs/pii/S1547527125013931
N2  - ackground Irreversible electroporation (pulse field ablation, PFA) is a promising alternative of the radiofrequency (RF) energy in catheter ablation of atrial fibrillation (AF). Objective The aim of this study is to present one-year results comparing efficacy and safety of catheter ablation for AF using CENTAURI PEF System (CardioFocus Inc.), FARAPULSE System (Boston Scientific), and standard RF ablation. Methods Patients referred for ablation of AF (paroxysmal and persistent) were enrolled in this study and randomly assigned to one of the three groups mentioned above. RF and CENTAURI group underwent ablation using the EnSite Precision 3D mapping system and TactiCath CF ablation catheter (Abbott) with point-to-point ablation using PFA (CENTAURI) or RF energy (RF group). FARAPULSE group underwent ablation with a specialized single-shot multipolar basket catheter under X-ray and intracardiac ultrasound Results Between May 2023 and November 2024, 265 patients underwent catheter ablation for AF (159 parox. AF, 106 pers. AF). The baseline characteristics of the groups were similar. Periprocedural results - see Table. Complications - CENTAURI and RF groups had no complications, FARAPULSE group had one stroke and one tamponade. 12-month follow up - CENTAURI, 29 pts, 72% in sinus rhythm; RF, 10 pts, 60% sinus rhythm; FARAPULSE, no follow-up visits. When analyzing both paroxysmal and persistent AF cases, Conclusion Ablation with all systems appears to be comparably effective and safe. FARAPULSE results in shortest procedure time but highest X-ray dose. CENTAURI tends to shorter procedure time and faster ipsilateral pulmonary vein isolation compared to standard RF ablation. Complications in the FARAPULSE group may be attributed to the learning curve. Long-term effectiveness is limited by the small number of patients with follow-up data.
ER  -

STÁREK, Zdeněk; Filip SOUČEK; Katarína DOLEŽALOVÁ; Martin PEŠL; Vojtěch ŠEBETOVSKÝ; Jakub HEJČ a Jan KREJČÍ. \textit{PO-04-037 A PROSPECTIVE RANDOMIZED CLINICAL COMPARISON OF CATHETER ABLATION OF ATRIAL FIBRILLATION USING THE CENTAURI PEF SYSTEM, FARAPULSE SYSTEM, AND STANDARD RADIOFREQUENCY CATHETER ABLATION}. 2025. Dostupné z: https://doi.org/10.1016/j.hrthm.2025.03.1172.

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