ADAR1: Beyond Just an RNA Editor

J 2025

ADAR1: Beyond Just an RNA Editor

MARÔNEK, Martin; Valentina LACOVICH STRAŠIL; Anna CHERIAN; Damiano AMORUSO; Pavla MUSILOVÁ et al.

Základní údaje

Originální název

ADAR1: Beyond Just an RNA Editor

Autoři

MARÔNEK, Martin; Valentina LACOVICH STRAŠIL ; Anna CHERIAN ; Damiano AMORUSO ; Pavla MUSILOVÁ ; Qiupei DU; Janka MELICHEROVÁ; Liam KEEGAN a Mary Anne O'CONNELL

Vydání

Annual Review of Cell and Developmental Biology, Annual Reviews Inc. 2025, 1081-0706

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 11.400 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

ADAR; interferon; innate immunity; Aicardi-Goutières syndrome; AGS; cancer

Štítky

143160

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 3. 2026 14:49, Mgr. Eva Dubská

Anotace

V originále

The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) has recently emerged from relative obscurity to be recognized as a key player in a variety of inflammatory diseases, including cancer. This growing recognition has generated interest in developing ADAR1 inhibitors; however, several fundamental questions about the enzyme need to be answered before ADAR1-based therapies can be successful. In this review, we summarize the current understanding of ADAR1, including its protein structure, RNA substrates, and roles in both innate and adaptive immunity. Recent studies have shed light on ADAR1 protein interactions and its RNA editing–independent functions. We also explore the involvement of ADAR1 in human diseases, with a focus on its roles in various cancers. Drosophila lacks an ADAR1 homolog; instead, the ADAR2 homolog is responsible for editing double-stranded RNA to prevent aberrant activation of the innate immune system. Finally, we address major questions in the field that still remain unanswered.

Návaznosti

GF22-26278K, projekt VaV

Název: Výzkum nových rolí ADAR1 v rakovině; produkce immunopeptidomu, propojení s p53 a účinek protinádorové léčby na aktivitu ADAR1.

Investor: Grantová agentura ČR, Výzkum nových rolí ADAR1 v rakovině, produkce immunopeptidomu, propojení s p53 a účinek protinádorové léčby na aktivitu ADAR1., Lead agentura

GX21-27329X, projekt VaV

Název: ADAR-dependentní RNA editace; Jak imunitní systém a mozek porušují Centrální Dogma.

Investor: Grantová agentura ČR, ADAR RNA editing, how immune systems and brains breach The Central Dogma

MUNI/R/1234/2022, interní kód MU

Název: Role of Adenosine Deaminase acting on RNA 2 (ADAR2) in the brain

Investor: Masarykova univerzita, Role of Adenosine Deaminase acting on RNA 2 (ADAR2) in the brain, CAREER RESTART

956810, interní kód MU

Název: ROles of ePitranscriptomic in diseasES (Akronym: ROPES)

Investor: Evropská unie, ROles of ePitranscriptomic in diseasES, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Citovat

MARÔNEK, Martin; Valentina LACOVICH STRAŠIL; Anna CHERIAN; Damiano AMORUSO; Pavla MUSILOVÁ; Qiupei DU; Janka MELICHEROVÁ; Liam KEEGAN a Mary Anne O'CONNELL. ADAR1: Beyond Just an RNA Editor. Annual Review of Cell and Developmental Biology. Annual Reviews Inc., 2025, roč. 41, č. 1, s. 529-551. ISSN 1081-0706. Dostupné z: https://doi.org/10.1146/annurev-cellbio-101323-020352.

@article{2511864,
   author = {Marônek, Martin and Lacovich Strašil, Valentina and Cherian, Anna and Amoruso, Damiano and Musilová, Pavla and Du, Qiupei and Melicherová, Janka and Keegan, Liam and O'Connell, Mary Anne},
   article_number = {1},
   doi = {https://doi.org/10.1146/annurev-cellbio-101323-020352},
   keywords = {ADAR; interferon; innate immunity; Aicardi-Goutières syndrome; AGS; cancer},
   language = {eng},
   issn = {1081-0706},
   journal = {Annual Review of Cell and Developmental Biology},
   title = {ADAR1: Beyond Just an RNA Editor},
   url = {https://www.annualreviews.org/content/journals/10.1146/annurev-cellbio-101323-020352},
   volume = {41},
   year = {2025}
}

TY  - JOUR
ID  - 2511864
AU  - Marônek, Martin - Lacovich Strašil, Valentina - Cherian, Anna - Amoruso, Damiano - Musilová, Pavla - Du, Qiupei - Melicherová, Janka - Keegan, Liam - O'Connell, Mary Anne
PY  - 2025
TI  - ADAR1: Beyond Just an RNA Editor
JF  - Annual Review of Cell and Developmental Biology
VL  - 41
IS  - 1
SP  - 529-551
EP  - 529-551
PB  - Annual Reviews Inc.
SN  - 10810706
KW  - ADAR
KW  - interferon
KW  - innate immunity
KW  - Aicardi-Goutières syndrome
KW  - AGS
KW  - cancer
UR  - https://www.annualreviews.org/content/journals/10.1146/annurev-cellbio-101323-020352
N2  - The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) has recently emerged from relative obscurity to be recognized as a key player in a variety of inflammatory diseases, including cancer. This growing recognition has generated interest in developing ADAR1 inhibitors; however, several fundamental questions about the enzyme need to be answered before ADAR1-based therapies can be successful. In this review, we summarize the current understanding of ADAR1, including its protein structure, RNA substrates, and roles in both innate and adaptive immunity. Recent studies have shed light on ADAR1 protein interactions and its RNA editing–independent functions. We also explore the involvement of ADAR1 in human diseases, with a focus on its roles in various cancers. Drosophila lacks an ADAR1 homolog; instead, the ADAR2 homolog is responsible for editing double-stranded RNA to prevent aberrant activation of the innate immune system. Finally, we address major questions in the field that still remain unanswered.
ER  -

MARÔNEK, Martin; Valentina LACOVICH STRAŠIL; Anna CHERIAN; Damiano AMORUSO; Pavla MUSILOVÁ; Qiupei DU; Janka MELICHEROVÁ; Liam KEEGAN a Mary Anne O'CONNELL. ADAR1: Beyond Just an RNA Editor. \textit{Annual Review of Cell and Developmental Biology}. Annual Reviews Inc., 2025, roč.~41, č.~1, s.~529-551. ISSN~1081-0706. Dostupné z: https://doi.org/10.1146/annurev-cellbio-101323-020352.

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