| BÁRTOVÁ, Eva, Stanislav KOZUBEK, Michal KOZUBEK, Pavla JIRSOVÁ, Emilie LUKÁŠOVÁ, Magdalena SKALNÍKOVÁ, Alena CAFOURKOVÁ a Irena KOUTNÁ. Nuclear topography of the c-myc gene in human leukemic cells. Gene. Amsterdam: Elsevier, 2000, roč. 244, č. 1, s. 1-11. ISSN 0378-1119. |
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@article{253471,
author = {Bártová, Eva and Kozubek, Stanislav and Kozubek, Michal and Jirsová, Pavla and Lukášová, Emilie and Skalníková, Magdalena and Cafourková, Alena and Koutná, Irena},
article_location = {Amsterdam},
article_number = {1},
keywords = {c-myc topography; differentiation; FISH; HL-60; U-937},
language = {eng},
issn = {0378-1119},
journal = {Gene},
title = {Nuclear topography of the c-myc gene in human leukemic cells},
url = {http://www.fi.muni.cz/lom/abstracts/lom005.shtml},
volume = {244},
year = {2000}
}
TY - JOUR
ID - 253471
AU - Bártová, Eva - Kozubek, Stanislav - Kozubek, Michal - Jirsová, Pavla - Lukášová, Emilie - Skalníková, Magdalena - Cafourková, Alena - Koutná, Irena
PY - 2000
TI - Nuclear topography of the c-myc gene in human leukemic cells
JF - Gene
VL - 244
IS - 1
SP - 1
EP - 1
PB - Elsevier
SN - 03781119
KW - c-myc topography
KW - differentiation
KW - FISH
KW - HL-60
KW - U-937
UR - http://www.fi.muni.cz/lom/abstracts/lom005.shtml
N2 - myc gene plays an essential role in the regulation of the cell cycle and differentiation. Therefore, changes of the c-myc positioning during differentiation are of great interest. As a model system of cell differentiation, the HL-60 and U-937 human leukemic cell lines, were used in our experiments. These cells can be induced to differentiation into granulocytes that represent one of the pathways of blood cell maturation. In this study, changes of the topographic characteristics of the c-myc gene (8q24), centromeric region of chromosome 8 and chromosome 8 domain during differentiation of HL-60 and U-937 cells were detected using fluorescence in situ hybridisation (FISH). FISH techniques and fluorescence microscopy combined with image acquisition and analysis (High Resolution Cytometry) were used in order to detect the topographic features of nuclear chromatin.
ER -
BÁRTOVÁ, Eva, Stanislav KOZUBEK, Michal KOZUBEK, Pavla JIRSOVÁ, Emilie LUKÁŠOVÁ, Magdalena SKALNÍKOVÁ, Alena CAFOURKOVÁ a Irena KOUTNÁ. Nuclear topography of the c-myc gene in human leukemic cells. \textit{Gene}. Amsterdam: Elsevier, 2000, roč.~244, č.~1, s.~1-11. ISSN~0378-1119.
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