Lymphopenia in glioblastoma and its association with brain
vessel irradiation: pilot retrospective evaluation of
dose-volume parameters

J 2025

Lymphopenia in glioblastoma and its association with brain vessel irradiation: pilot retrospective evaluation of dose-volume parameters

HNIDÁKOVÁ, Lucie; Iveta SELINGEROVÁ; Petr POSPÍŠIL; Jana HALÁMKOVÁ; Renata BELANOVA et al.

Základní údaje

Originální název

Lymphopenia in glioblastoma and its association with brain vessel irradiation: pilot retrospective evaluation of dose-volume parameters

Autoři

Vydání

Neoplasma, Bratislava, Aepress, 2025, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL, URL

Impakt faktor

Impact factor: 2.200 v roce 2024

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.4149/neo_2025_250730N330

UT WoS

001650550700007

EID Scopus

999

Klíčová slova česky

glioblastoma; radiotherapy; lymphopenia

Klíčová slova anglicky

glioblastoma; radiotherapy; lymphopenia

Štítky

14110131, 14110513, 14110811, 14110812, 14311010, CZECRIN, Excelence Science, MOÚ, RIV, user, článek v časopise

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 1. 2026 14:00, Mgr. Tereza Miškechová

Anotace

V originále

Radiotherapy (RT) plays a central role in the management of glioblastoma, often in combination with other treatment modalities. While RT can enhance both local and systemic tumor control, especially when used alongside immunotherapy, it is also associated with lymphopenia - a reduction in lymphocyte count - which has been linked to poorer treatment outcomes and reduced survival. This retrospective study aimed to examine the relationship between radiation dose delivered to brain vessels and the severity of lymphopenia in patients with newly diagnosed glioblastoma treated at a tertiary cancer center in 2021. Brain vessels were manually contoured using MRI data, and dose-volume analysis was conducted. Lymphopenia severity was graded according to CTCAE v5.0, and statistical analyses were performed to identify any correlations. Among the 28 patients analyzed, 32% developed grade 1-3 lymphopenia. No significant correlation was found between the radiation dose to brain vessels and the degree of lymphopenia. The median volume of irradiated vessels did not differ significantly between patients with and without lymphopenia. In glioblastoma patients, multiple factors contribute to decreased lymphocyte count - e.g., chemotherapy and corticosteroid use. Although no definitive link was identified, the study underscores the importance of preserving lymphocyte counts during glioblastoma treatment and supports the need for further prospective research to explore strategies like lymphocyte-sparing RT and to better understand the mechanisms behind treatment-related lymphopenia.

Návaznosti

EH22_008/0004644, projekt VaV

Název: Záchrana životů prostřednictvím výzkumu v oblasti včasné detekce a prevence rakoviny: Molekulární, genomické a sociální faktory

NU22-03-00290, projekt VaV

Název: Studium exosomálních mikroRNA u gliomů: implikace pro diagnostiku a inovativní terapii

Investor: Ministerstvo zdravotnictví ČR, Studium exosomálních mikroRNA u gliomů: implikace pro diagnostiku a inovativní terapii, Podprogram 1 - standardní

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

HNIDÁKOVÁ, Lucie; Iveta SELINGEROVÁ; Petr POSPÍŠIL; Jana HALÁMKOVÁ; Renata BELANOVA; Tomas NIKL; Jiří ŠÁNA; Barbora VAVRUŠÁKOVÁ; Renata BARTOŠOVÁ; Ondřej SLABÝ; Pavel ŠLAMPA; Radim JANČÁLEK; Giuseppe MINNITI a Tomáš KAZDA. Lymphopenia in glioblastoma and its association with brain vessel irradiation: pilot retrospective evaluation of dose-volume parameters. Neoplasma. Bratislava: Aepress, 2025, roč. 72, č. 5, s. 371-378. ISSN 0028-2685. Dostupné z: https://doi.org/10.4149/neo_2025_250730N330.

@article{2548332,
   author = {Hnidáková, Lucie and Selingerová, Iveta and Pospíšil, Petr and Halámková, Jana and Belanova, Renata and Nikl, Tomas and Šána, Jiří and Vavrušáková, Barbora and Bartošová, Renata and Slabý, Ondřej and Šlampa, Pavel and Jančálek, Radim and Minniti, Giuseppe and Kazda, Tomáš},
   article_location = {Bratislava},
   article_number = {5},
   doi = {https://doi.org/10.4149/neo_2025_250730N330},
   keywords = {glioblastoma; radiotherapy; lymphopenia},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Lymphopenia in glioblastoma and its association with brain vessel irradiation: pilot retrospective evaluation of dose-volume parameters},
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   volume = {72},
   year = {2025}
}

TY  - JOUR
ID  - 2548332
AU  - Hnidáková, Lucie - Selingerová, Iveta - Pospíšil, Petr - Halámková, Jana - Belanova, Renata - Nikl, Tomas - Šána, Jiří - Vavrušáková, Barbora - Bartošová, Renata - Slabý, Ondřej - Šlampa, Pavel - Jančálek, Radim - Minniti, Giuseppe - Kazda, Tomáš
PY  - 2025
TI  - Lymphopenia in glioblastoma and its association with brain vessel irradiation: pilot retrospective evaluation of dose-volume parameters
JF  - Neoplasma
VL  - 72
IS  - 5
SP  - 371-378
EP  - 371-378
PB  - Aepress
SN  - 00282685
KW  - glioblastoma
KW  - radiotherapy
KW  - lymphopenia
UR  - https://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=8552&category_id=200&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - Radiotherapy (RT) plays a central role in the management of glioblastoma, often in combination with other treatment modalities. While RT can enhance both local and systemic tumor control, especially when used alongside immunotherapy, it is also associated with lymphopenia - a reduction in lymphocyte count - which has been linked to poorer treatment outcomes and reduced survival. This retrospective study aimed to examine the relationship between radiation dose delivered to brain vessels and the severity of lymphopenia in patients with newly diagnosed glioblastoma treated at a tertiary cancer center in 2021. Brain vessels were manually contoured using MRI data, and dose-volume analysis was conducted. Lymphopenia severity was graded according to CTCAE v5.0, and statistical analyses were performed to identify any correlations. Among the 28 patients analyzed, 32% developed grade 1-3 lymphopenia. No significant correlation was found between the radiation dose to brain vessels and the degree of lymphopenia. The median volume of irradiated vessels did not differ significantly between patients with and without lymphopenia. In glioblastoma patients, multiple factors contribute to decreased lymphocyte count - e.g., chemotherapy and corticosteroid use. Although no definitive link was identified, the study underscores the importance of preserving lymphocyte counts during glioblastoma treatment and supports the need for further prospective research to explore strategies like lymphocyte-sparing RT and to better understand the mechanisms behind treatment-related lymphopenia.
ER  -

HNIDÁKOVÁ, Lucie; Iveta SELINGEROVÁ; Petr POSPÍŠIL; Jana HALÁMKOVÁ; Renata BELANOVA; Tomas NIKL; Jiří ŠÁNA; Barbora VAVRUŠÁKOVÁ; Renata BARTOŠOVÁ; Ondřej SLABÝ; Pavel ŠLAMPA; Radim JANČÁLEK; Giuseppe MINNITI a Tomáš KAZDA. Lymphopenia in glioblastoma and its association with brain vessel irradiation: pilot retrospective evaluation of dose-volume parameters. \textit{Neoplasma}. Bratislava: Aepress, 2025, roč.~72, č.~5, s.~371-378. ISSN~0028-2685. Dostupné z: https://doi.org/10.4149/neo\_{}2025\_{}250730N330.

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