PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA
GENETICALLY DIFFERS FROM THE ADULT COUNTERPART

J 2025

PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART

JAMES, Emily R; Julia SALMERON-VILLALOBOS; Ariadna COLMENERO; Leonie FRAUENFELD; Mara ANDRES et al.

Základní údaje

Originální název

PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART

Autoři

Vydání

Leukemia Research, Oxford, Pergamon-Elsevier Science LTD, 2025, 0145-2126

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.200 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00143525

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.leukres.2025.108025

UT WoS

001603165200065

Klíčová slova česky

PEDIATRIC; ALK-NEGATIVE ANAPLASTIC; LARGE CELL LYMPHOMA

Klíčová slova anglicky

PEDIATRIC; ALK-NEGATIVE ANAPLASTIC; LARGE CELL LYMPHOMA

Štítky

CZECRIN, Excelence Science, RIV, user, článek v časopise

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 4. 2026 12:48, Mgr. Petra Trembecká, Ph.D.

Anotace

V originále

Background: Systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK- ALCL) predominantly affects adults, whereas pediatric and young adult ALK- ALCL cases are rare. For adult ALK- ALCL, studies have uncovered recurrent rearrangements of DUSP22 (31%) and VAV1 (16%) and, at lower frequencies, ROS1, TYK2, FRK, and TP63 rearrangements as well as JAK1 and/or STAT3 activating mutations1,2. However, none of these studies included pediatric or young adult patients. Objectives: The aim of this study was to characterize the genetic landscape of pediatric and young adult systemic ALK- ALCL and primary cutaneous CD30-positive T-cell lymphoproliferative disorders (pcCD30+ LPD).

Návaznosti

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

JAMES, Emily R; Julia SALMERON-VILLALOBOS; Ariadna COLMENERO; Leonie FRAUENFELD; Mara ANDRES; Jamie VERDU; Noelia GARCIA; Ingrid SIMONITSCH-KLUPP; Andishe ATTARBASCHI; Chris M BACON; G A Amos BURKE; Brian LOCKHART; Stephen P DUCRAY; Zi CHEN; Maria-Myrsini TZIONI; Jamie D MATTHEWS; Christopher STEEL; Marta PILLON; Lara MUSSOLIN; Shahid PERVEZ; Vinodh PILLAI; Jaroslav ŠTĚRBA; Zdenka KRENOVA; Margreet A VEENING; Grazyna WROBEL; Jana WERNER; Fabian KNORR; Ilske OSCHLIES; Wolfram KLAPPER; Wilhelm WOESSMANN; Olga BALAGUE; Itziar SALAVERRIA a Suzanne Dawn TURNER. PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART. Leukemia Research. Oxford: Pergamon-Elsevier Science LTD, 2025, roč. 156, NA, s. 1-1. ISSN 0145-2126. Dostupné z: https://doi.org/10.1016/j.leukres.2025.108025.

@article{2549206,
   author = {James, Emily R and SalmeronandVillalobos, Julia and Colmenero, Ariadna and Frauenfeld, Leonie and Andres, Mara and Verdu, Jamie and Garcia, Noelia and SimonitschandKlupp, Ingrid and Attarbaschi, Andishe and Bacon, Chris M and Burke, G A Amos and Lockhart, Brian and Ducray, Stephen P and Chen, Zi and Tzioni, MariaandMyrsini and Matthews, Jamie D and Steel, Christopher and Pillon, Marta and Mussolin, Lara and Pervez, Shahid and Pillai, Vinodh and Štěrba, Jaroslav and Krenova, Zdenka and Veening, Margreet A and Wrobel, Grazyna and Werner, Jana and Knorr, Fabian and Oschlies, Ilske and Klapper, Wolfram and Woessmann, Wilhelm and Balague, Olga and Salaverria, Itziar and Turner, Suzanne Dawn},
   article_location = {Oxford},
   article_number = {NA},
   doi = {https://doi.org/10.1016/j.leukres.2025.108025},
   keywords = {PEDIATRIC; ALK-NEGATIVE ANAPLASTIC; LARGE CELL LYMPHOMA},
   language = {eng},
   issn = {0145-2126},
   journal = {Leukemia Research},
   title = {PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART},
   url = {https://www.sciencedirect.com/science/article/pii/S0145212625004692?pes=vor&utm_source=clarivate&getft_integrator=clarivate},
   volume = {156},
   year = {2025}
}

TY  - JOUR
ID  - 2549206
AU  - James, Emily R - Salmeron-Villalobos, Julia - Colmenero, Ariadna - Frauenfeld, Leonie - Andres, Mara - Verdu, Jamie - Garcia, Noelia - Simonitsch-Klupp, Ingrid - Attarbaschi, Andishe - Bacon, Chris M - Burke, G A Amos - Lockhart, Brian - Ducray, Stephen P - Chen, Zi - Tzioni, Maria-Myrsini - Matthews, Jamie D - Steel, Christopher - Pillon, Marta - Mussolin, Lara - Pervez, Shahid - Pillai, Vinodh - Štěrba, Jaroslav - Krenova, Zdenka - Veening, Margreet A - Wrobel, Grazyna - Werner, Jana - Knorr, Fabian - Oschlies, Ilske - Klapper, Wolfram - Woessmann, Wilhelm - Balague, Olga - Salaverria, Itziar - Turner, Suzanne Dawn
PY  - 2025
TI  - PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART
JF  - Leukemia Research
VL  - 156
IS  - NA
SP  - 1-1
EP  - 1-1
PB  - Pergamon-Elsevier Science LTD
SN  - 01452126
KW  - PEDIATRIC
KW  - ALK-NEGATIVE ANAPLASTIC
KW  - LARGE CELL LYMPHOMA
UR  - https://www.sciencedirect.com/science/article/pii/S0145212625004692?pes=vor&utm_source=clarivate&getft_integrator=clarivate
N2  - Background: Systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK- ALCL) predominantly affects adults, whereas pediatric and young adult ALK- ALCL cases are rare. For adult ALK- ALCL, studies have uncovered recurrent rearrangements of DUSP22 (31%) and VAV1 (16%) and, at lower frequencies, ROS1, TYK2, FRK, and TP63 rearrangements as well as JAK1 and/or STAT3 activating mutations1,2. However, none of these studies included pediatric or young adult patients. Objectives: The aim of this study was to characterize the genetic landscape of pediatric and young adult systemic ALK- ALCL and primary cutaneous CD30-positive T-cell lymphoproliferative disorders (pcCD30+ LPD).
ER  -

JAMES, Emily R; Julia SALMERON-VILLALOBOS; Ariadna COLMENERO; Leonie FRAUENFELD; Mara ANDRES; Jamie VERDU; Noelia GARCIA; Ingrid SIMONITSCH-KLUPP; Andishe ATTARBASCHI; Chris M BACON; G A Amos BURKE; Brian LOCKHART; Stephen P DUCRAY; Zi CHEN; Maria-Myrsini TZIONI; Jamie D MATTHEWS; Christopher STEEL; Marta PILLON; Lara MUSSOLIN; Shahid PERVEZ; Vinodh PILLAI; Jaroslav ŠTĚRBA; Zdenka KRENOVA; Margreet A VEENING; Grazyna WROBEL; Jana WERNER; Fabian KNORR; Ilske OSCHLIES; Wolfram KLAPPER; Wilhelm WOESSMANN; Olga BALAGUE; Itziar SALAVERRIA a Suzanne Dawn TURNER. PEDIATRIC ALK-NEGATIVE ANAPLASTIC LARGE CELL LYMPHOMA GENETICALLY DIFFERS FROM THE ADULT COUNTERPART. \textit{Leukemia Research}. Oxford: Pergamon-Elsevier Science LTD, 2025, roč.~156, NA, s.~1-1. ISSN~0145-2126. Dostupné z: https://doi.org/10.1016/j.leukres.2025.108025.

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