GDM as a unique pathophysiological entity or a transitional
pregnancy-induced glucose metabolism abnormality identifying
primary diabetes types?

J 2026

GDM as a unique pathophysiological entity or a transitional pregnancy-induced glucose metabolism abnormality identifying primary diabetes types?

BARTÁKOVÁ, Vendula; Eliška AMBROŽOVÁ; Petr ŽÁK a Kateřina KAŇKOVÁ

Základní údaje

Originální název

GDM as a unique pathophysiological entity or a transitional pregnancy-induced glucose metabolism abnormality identifying primary diabetes types?

Autoři

BARTÁKOVÁ, Vendula ; Eliška AMBROŽOVÁ; Petr ŽÁK a Kateřina KAŇKOVÁ

Vydání

Frontiers in Physiology, FRONTIERS RESEARCH FOUNDATION, 2026, 1664-042X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.400 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

diabetes in pregnancy; gestational diabetes mellitus; glucose metabolism abnormality; metabolic programming; postpartum diabetes risk

Štítky

14110116, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2026 11:58, Mgr. Tereza Miškechová

Anotace

V originále

Gestational diabetes mellitus is defined as glucose intolerance first diagnosed during pregnancy; however, this diagnosis may actually represent a heterogeneous spectrum of primary diabetes phenotypes unmasked by the metabolic stress of pregnancy rather than a single pathophysiological entity. The current review aims to summarise available knowledge about the diabetes spectrum in pregnancy with particular focus on its pathophysiology, risk factors and postpartum destiny. Another aim was to discuss possibilities for stratification of the women according to their immediate and future risks of postpartum persistence of glucose intolerance and its complications in later life. Specific objectives of the paper are: (1) to summarise data on physiological metabolic changes in pregnancy, (2) characterise the diabetes spectrum in pregnancy, (3) address the current state of the art in GDM diagnosis and management, (4) to summarize data on postnatal development and maturation of the infants who experienced GDM in utero and, finally (5) discuss possibilities to stratify GDM women according to the later risk for persistence of glucose intolerance after delivery.

Návaznosti

LX22NPO5104, projekt VaV

Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES

MUNI/A/1559/2024, interní kód MU

Název: Patofyziologie, epidemiologie, diferenciální diagnostika a odhad prognózy vybraných vnitřních nemocí 2

Investor: Masarykova univerzita, Patofyziologie, epidemiologie, diferenciální diagnostika a odhad prognózy vybraných vnitřních nemocí 2

NW24-01-00285, projekt VaV

Název: Vytvoření kompozitního stratifikačního skóre predikujícího vyšší výskyt perinatálních komplikací a poporodní persistence diabetu u žen s gestačním diabetes mellitus

Investor: Ministerstvo zdravotnictví ČR, Vytvoření kompozitního stratifikačního skóre predikujícího vyšší výskyt perinatálních komplikací a poporodní persistence diabetu u žen s gestačním diabetes mellitus, Podprogram 1 - standardní

Citovat

BARTÁKOVÁ, Vendula; Eliška AMBROŽOVÁ; Petr ŽÁK a Kateřina KAŇKOVÁ. GDM as a unique pathophysiological entity or a transitional pregnancy-induced glucose metabolism abnormality identifying primary diabetes types? Frontiers in Physiology. FRONTIERS RESEARCH FOUNDATION, 2026, roč. 2026, č. 17, s. 1-9, 10 s. ISSN 1664-042X. Dostupné z: https://doi.org/10.3389/fphys.2026.1778006.

@article{2557260,
   author = {Bartáková, Vendula and Ambrožová, Eliška and Žák, Petr and Kaňková, Kateřina},
   article_number = {17},
   doi = {https://doi.org/10.3389/fphys.2026.1778006},
   keywords = {diabetes in pregnancy; gestational diabetes mellitus; glucose metabolism abnormality; metabolic programming; postpartum diabetes risk},
   language = {eng},
   issn = {1664-042X},
   journal = {Frontiers in Physiology},
   title = {GDM as a unique pathophysiological entity or a transitional pregnancy-induced glucose metabolism abnormality identifying primary diabetes types?},
   url = {https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1778006/full},
   volume = {2026},
   year = {2026}
}

TY  - JOUR
ID  - 2557260
AU  - Bartáková, Vendula - Ambrožová, Eliška - Žák, Petr - Kaňková, Kateřina
PY  - 2026
TI  - GDM as a unique pathophysiological entity or a transitional pregnancy-induced glucose metabolism abnormality identifying primary diabetes types?
JF  - Frontiers in Physiology
VL  - 2026
IS  - 17
SP  - 1-9
EP  - 1-9
PB  - FRONTIERS RESEARCH FOUNDATION
SN  - 1664042X
KW  - diabetes in pregnancy
KW  - gestational diabetes mellitus
KW  - glucose metabolism abnormality
KW  - metabolic programming
KW  - postpartum diabetes risk
UR  - https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1778006/full
N2  - Gestational diabetes mellitus is defined as glucose intolerance first diagnosed during pregnancy; however, this diagnosis may actually represent a heterogeneous spectrum of primary diabetes phenotypes unmasked by the metabolic stress of pregnancy rather than a single pathophysiological entity. The current review aims to summarise available knowledge about the diabetes spectrum in pregnancy with particular focus on its pathophysiology, risk factors and postpartum destiny. Another aim was to discuss possibilities for stratification of the women according to their immediate and future risks of postpartum persistence of glucose intolerance and its complications in later life. Specific objectives of the paper are: (1) to summarise data on physiological metabolic changes in pregnancy, (2) characterise the diabetes spectrum in pregnancy, (3) address the current state of the art in GDM diagnosis and management, (4) to summarize data on postnatal development and maturation of the infants who experienced GDM in utero and, finally (5) discuss possibilities to stratify GDM women according to the later risk for persistence of glucose intolerance after delivery.
ER  -

BARTÁKOVÁ, Vendula; Eliška AMBROŽOVÁ; Petr ŽÁK a Kateřina KAŇKOVÁ. GDM as a unique pathophysiological entity or a transitional pregnancy-induced glucose metabolism abnormality identifying primary diabetes types? \textit{Frontiers in Physiology}. FRONTIERS RESEARCH FOUNDATION, 2026, roč.~2026, č.~17, s.~1-9, 10 s. ISSN~1664-042X. Dostupné z: https://doi.org/10.3389/fphys.2026.1778006.

Přehled o publikaci