The effects of RARa and RXRa proteins on growth, viability and
differentiation of v-myb-transformed monoblasts

J 2000

The effects of RARa and RXRa proteins on growth, viability and differentiation of v-myb-transformed monoblasts

VODIČKA, Petr; Sabina ŠEVČÍKOVÁ; Jana ŠMARDOVÁ; Karel SOUČEK; Jan ŠMARDA et. al.

Základní údaje

Originální název

The effects of RARa and RXRa proteins on growth, viability and differentiation of v-myb-transformed monoblasts

Autoři

VODIČKA, Petr; Sabina ŠEVČÍKOVÁ; Jana ŠMARDOVÁ; Karel SOUČEK a Jan ŠMARDA

Vydání

Blood Cells, Molecules and Diseases, Orlando, Florida, Academic Press, 2000, 1079-9796

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.897

Kód RIV

RIV/00216224:14310/00:00003362

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1006/bcmd.2000.0316

UT WoS

000089957500014

Klíčová slova anglicky

v-myb; retinoic acid receptors; transactivation; proliferation; differentiation

Štítky

differentiation, proliferation, retinoic acid receptors, transactivation, v-Myb

Změněno: 20. 10. 2025 15:52, Mgr. Petra Trembecká, Ph.D.

Anotace

V originále

Retinoids are important agents which regulate differentiation and proliferation processes in various cell types, including cancer cells. Growth arrest and induction of terminal differentiation demonstrate the tumor-suppressive effects of retinoids on leukemic cells. We studied differentiation, proliferation, and death processes in the cell line of v-myb-transformed monoblasts BM2 and their retinoic acid receptor (RAR) alpha- and retinoid X receptor (RXR) ct-expressing derivatives after exposure to four different retinoids: all-trans retinoic acid, 9-cis retinoic acid, TTNPB, and LG1000153. The effects of retinoids on the phenotype of BM2, BM2RAR, and BM2RXR cells were correlated with the transcription activation function of the v-Myb oncoprotein of avian myeloblastosis virus. We found that the efficiency of terminal differentiation of BM2RAR and BM2RXR cells induced by retinoids is indirectly proportional to the v-Myb transcription activation activity. In contrast, the effects of liganded retinoid receptors on growth of BM2 cells are more complex. Activated RAR protein induces growth inhibition of BM2 cells by suppression of v-Myb function. However, liganded RXR protein is less efficient in cell cycle arrest and rather decreases cellular viability. This process can occur in the presence of active v-Myb protein. These results suggest that ligand-activated RAR alpha protein is primarily engaged in control of proliferation and differentiation of v-myb-transformed monoblasts, while activated RXR alpha protein controls their differentiation and death, (C) 2000 Academic Press.

Návaznosti

GA312/98/0679, projekt VaV

Název: Interakce proteinů Myb, Fos, Jun a retinoidových receptorů při antileukemických procesech

Investor: Grantová agentura ČR, Interakce proteinů Myb, Fos, Jun a retinoidových receptorů při antileukemických procesech

Citovat

VODIČKA, Petr; Sabina ŠEVČÍKOVÁ; Jana ŠMARDOVÁ; Karel SOUČEK a Jan ŠMARDA. The effects of RARa and RXRa proteins on growth, viability and differentiation of v-myb-transformed monoblasts. Blood Cells, Molecules and Diseases. Orlando, Florida: Academic Press, 2000, roč. 26, č. 4, s. 395-406. ISSN 1079-9796. Dostupné z: https://doi.org/10.1006/bcmd.2000.0316.

@article{339254,
   author = {Vodička, Petr and Ševčíková, Sabina and Šmardová, Jana and Souček, Karel and Šmarda, Jan},
   article_location = {Orlando, Florida},
   article_number = {4},
   doi = {https://doi.org/10.1006/bcmd.2000.0316},
   keywords = {v-myb; retinoic acid receptors; transactivation; proliferation; differentiation},
   language = {eng},
   issn = {1079-9796},
   journal = {Blood Cells, Molecules and Diseases},
   title = {The effects of RARa and RXRa proteins on growth, viability and differentiation of v-myb-transformed monoblasts},
   url = {https://www.sciencedirect.com/science/article/pii/S1079979600903164?pes=vor&utm_source=clarivate&getft_integrator=clarivate},
   volume = {26},
   year = {2000}
}

TY  - JOUR
ID  - 339254
AU  - Vodička, Petr - Ševčíková, Sabina - Šmardová, Jana - Souček, Karel - Šmarda, Jan
PY  - 2000
TI  - The effects of RARa and RXRa proteins on growth, viability and differentiation of v-myb-transformed monoblasts
JF  - Blood Cells, Molecules and Diseases
VL  - 26
IS  - 4
SP  - 395
EP  - 395
PB  - Academic Press
SN  - 10799796
KW  - v-myb
KW  - retinoic acid receptors
KW  - transactivation
KW  - proliferation
KW  - differentiation
UR  - https://www.sciencedirect.com/science/article/pii/S1079979600903164?pes=vor&utm_source=clarivate&getft_integrator=clarivate
N2  - Retinoids are important agents which regulate differentiation and proliferation processes in various cell types, including cancer cells. Growth arrest and induction of terminal differentiation demonstrate the tumor-suppressive effects of retinoids on leukemic cells. We studied differentiation, proliferation, and death processes in the cell line of v-myb-transformed monoblasts BM2 and their retinoic acid receptor (RAR) alpha- and retinoid X receptor (RXR) ct-expressing derivatives after exposure to four different retinoids: all-trans retinoic acid, 9-cis retinoic acid, TTNPB, and LG1000153. The effects of retinoids on the phenotype of BM2, BM2RAR, and BM2RXR cells were correlated with the transcription activation function of the v-Myb oncoprotein of avian myeloblastosis virus. We found that the efficiency of terminal differentiation of BM2RAR and BM2RXR cells induced by retinoids is indirectly proportional to the v-Myb transcription activation activity. In contrast, the effects of liganded retinoid receptors on growth of BM2 cells are more complex. Activated RAR protein induces growth inhibition of BM2 cells by suppression of v-Myb function. However, liganded RXR protein is less efficient in cell cycle arrest and rather decreases cellular viability. This process can occur in the presence of active v-Myb protein. These results suggest that ligand-activated RAR alpha protein is primarily engaged in control of proliferation and differentiation of v-myb-transformed monoblasts, while activated RXR alpha protein controls their differentiation and death, (C) 2000 Academic Press.
ER  -

VODIČKA, Petr; Sabina ŠEVČÍKOVÁ; Jana ŠMARDOVÁ; Karel SOUČEK a Jan ŠMARDA. The effects of RARa and RXRa proteins on growth, viability and differentiation of v-myb-transformed monoblasts. \textit{Blood Cells, Molecules and Diseases}. Orlando, Florida: Academic Press, 2000, roč.~26, č.~4, s.~395-406. ISSN~1079-9796. Dostupné z: https://doi.org/10.1006/bcmd.2000.0316.

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