Telomerase activity and expression in the course of treatment
of acute childhood leukemias

D 2000

Telomerase activity and expression in the course of treatment of acute childhood leukemias

MALÁSKA, Jan; Jiří FAJKUS; Milan BAJER; Hana HRSTKOVÁ; Kateřina BAJEROVÁ et al.

Základní údaje

Originální název

Telomerase activity and expression in the course of treatment of acute childhood leukemias

Autoři

MALÁSKA, Jan; Jiří FAJKUS ; Milan BAJER; Hana HRSTKOVÁ; Kateřina BAJEROVÁ; Jaroslav MICHÁLEK; Lenka FAJKUSOVÁ; Rostislav VYZULA; Kateřina KREJČÍ a Marie SKLENIČKOVÁ

Vydání

2000. vyd. Oxford, Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER, od s. 29a, 1 s. 2000

Nakladatel

Oxford University Press

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 11.542

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/00:00002452

Organizační jednotka

Přírodovědecká fakulta

ISSN

Klíčová slova anglicky

Telomerase activity

Štítky

telomerase activity

Změněno: 24. 6. 2008 16:01, prof. RNDr. Jiří Fajkus, CSc.

Anotace

V originále

Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.

Návaznosti

GA301/99/0045, projekt VaV

Název: Dynamika telomer u vybraných typů solidních maligních onemocnění

Investor: Grantová agentura ČR, Dynamika telomer u vybraných typů solidních maligních onemocnění

MSM 143100008, záměr

Název: Genomy a jejich funkce

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Genomy a jejich funkce

VS97032, projekt VaV

Název: Analýza biologicky významných molekulárních komplexů

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Analýza biologicky významných molekulárních komplexů

Citovat

MALÁSKA, Jan; Jiří FAJKUS; Milan BAJER; Hana HRSTKOVÁ; Kateřina BAJEROVÁ; Jaroslav MICHÁLEK; Lenka FAJKUSOVÁ; Rostislav VYZULA; Kateřina KREJČÍ a Marie SKLENIČKOVÁ. Telomerase activity and expression in the course of treatment of acute childhood leukemias. In Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER. 2000. vyd. Oxford: Oxford University Press, 2000, s. 29a, 1 s. ISSN 1087-0156.

@inproceedings{343215,
   author = {Maláska, Jan and Fajkus, Jiří and Bajer, Milan and Hrstková, Hana and Bajerová, Kateřina and Michálek, Jaroslav and Fajkusová, Lenka and Vyzula, Rostislav and Krejčí, Kateřina and Skleničková, Marie},
   address = {Oxford},
   booktitle = {Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER},
   edition = {2000},
   keywords = {Telomerase activity},
   language = {eng},
   location = {Oxford},
   pages = {29a},
   publisher = {Oxford University Press},
   title = {Telomerase activity and expression in the course of treatment of acute childhood leukemias},
   year = {2000}
}

TY  - CONF
ID  - 343215
AU  - Maláska, Jan - Fajkus, Jiří - Bajer, Milan - Hrstková, Hana - Bajerová, Kateřina - Michálek, Jaroslav - Fajkusová, Lenka - Vyzula, Rostislav - Krejčí, Kateřina - Skleničková, Marie
PY  - 2000
TI  - Telomerase activity and expression in the course of treatment of acute childhood leukemias
PB  - Oxford University Press
CY  - Oxford
KW  - Telomerase activity
N2  - Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.
ER  -

MALÁSKA, Jan; Jiří FAJKUS; Milan BAJER; Hana HRSTKOVÁ; Kateřina BAJEROVÁ; Jaroslav MICHÁLEK; Lenka FAJKUSOVÁ; Rostislav VYZULA; Kateřina KREJČÍ a Marie SKLENIČKOVÁ. Telomerase activity and expression in the course of treatment of acute childhood leukemias. In \textit{Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER}. 2000. vyd. Oxford: Oxford University Press, 2000, s.~29a, 1 s. ISSN~1087-0156.

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