| IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ a Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. Genes Immun. United Kingdom: Nature Publishing Group, 2002, roč. 3, č. 5, s. 292-294. ISSN 1466-4879. |
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@article{395771,
author = {Izakovičová Hollá, Lydie and Bučková, Dana and Fassmann, Antonín and Beneš, Petr and Znojil, Vladimír},
article_location = {United Kingdom},
article_number = {5},
keywords = {gene; polymorphism; PAI-1; periodontitis},
language = {eng},
issn = {1466-4879},
journal = {Genes Immun},
title = {Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers},
volume = {3},
year = {2002}
}
TY - JOUR
ID - 395771
AU - Izakovičová Hollá, Lydie - Bučková, Dana - Fassmann, Antonín - Beneš, Petr - Znojil, Vladimír
PY - 2002
TI - Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers
JF - Genes Immun
VL - 3
IS - 5
SP - 292
EP - 292
PB - Nature Publishing Group
SN - 14664879
KW - gene
KW - polymorphism
KW - PAI-1
KW - periodontitis
N2 - Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases We investigated relationships among adult periodontitis, smoking and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (p=0.0022, Pcorr.LT.0.01, p=0.014, Pcorr.LT.0.05). Even a stronger association occurred in non-smokers (p=0.00021, Pcorr.LT.0.01, p=0.0024, Pcorr.LT.0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis.
ER -
IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ a Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. \textit{Genes Immun}. United Kingdom: Nature Publishing Group, 2002, roč.~3, č.~5, s.~292-294. ISSN~1466-4879.
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