Polymorphism NcoI in tumor necrosis factor b is associated with
fasting glycemia and lipid parameters in healthy non-obese
Caucasian subjects: Preliminary report

J 2002

Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report

KAŇKOVÁ, Kateřina; Ivana MÁROVÁ; Eugene HJM JANSEN; Anna VAŠKŮ; Michal JURAJDA et al.

Základní údaje

Originální název

Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report

Název česky

Polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry u zdravych neobeznich osob: predbezne vysledky

Autoři

KAŇKOVÁ, Kateřina; Ivana MÁROVÁ; Eugene HJM JANSEN; Anna VAŠKŮ; Michal JURAJDA a Jiří VÁCHA

Vydání

Diabetes & Metabolism, Francie, Editions Masson, 2002, 0338-1684

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Francie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.546 v roce 2001

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/02:00005552

Organizační jednotka

Lékařská fakulta

UT WoS

000176985000009

Klíčová slova anglicky

Type 2 diabetes mellitus; TNF-b polymorphism; insulin resistance; glycemia; glucose intolerance

Štítky

glucose intolerance, glycemia, insulin resistance, TNF-b polymorphism, type 2 diabetes mellitus

Změněno: 18. 6. 2009 09:51, prof. MUDr. Anna Vašků, CSc.

Anotace

ORIG CZ

V originále

Background: The study was designed to investigate the associations among polymorphisms TNF-b NcoI and TNF-a -308G/A, plasma TNF-a levels and metabolic and anthropometric parameters related to insulin sensitivity in a set of 113 Caucasian subjects undergoing oral glucose tolerance test (oGTT). Methods: Genotypes were detected by PCR; BMI, WHR, glycemia during oGTT, fasting immunoreactive insulin, fasting C-peptide, HbA1c, total cholesterol, triglycerides, HDL, LDL and plasma TNF-a levels were measured in each subject. Results: Type 2 diabetes was diagnosed in 10 subjects, impaired glucose tolerance (IGT) in 41, normal glucose tolerance (NGT) in 62. Significant differences among genotypes of the TNF-b NcoI were observed for FPG (P=0.0063), LDL (P=0.0179) and marginally for total cholesterol (P=0.0763) in NGT group. After the classification of NGT subjects into obese and non-obese according to BMI, associations of TNF-b NcoI with FPG, LDL and cholesterol were proved in non-obese subgroup only. TNF-a -308G/A polymorphism was not associated with any of the parameters studied. TNF-a levels did not revealed difference among NGT, IGT and DM groups or genotype-dependent differences. Conclusions: Our results indicate significant association of the TNF-b NcoI polymorphism with FPG, LDL and total cholesterol in normoglycemic non-obese Caucasian subjects. This polymorphism could be involved in genetic modulation of glucose and lipid homeostasis and regulation of insulin sensitivity already in healthy state. Disturbances of this regulation could be component of pathogenesis of type 2 diabetes mellitus.

Česky

Zjistili jsme, ze polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry (LDL a cholesterol) u zdravych neobeznich osob.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

KAŇKOVÁ, Kateřina; Ivana MÁROVÁ; Eugene HJM JANSEN; Anna VAŠKŮ; Michal JURAJDA a Jiří VÁCHA. Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report. Diabetes & Metabolism. Francie: Editions Masson, 2002, roč. 28, č. 3, s. 231-237. ISSN 0338-1684.

@article{399632,
   author = {Kaňková, Kateřina and Márová, Ivana and Jansen, Eugene HJM and Vašků, Anna and Jurajda, Michal and Vácha, Jiří},
   article_location = {Francie},
   article_number = {3},
   keywords = {Type 2 diabetes mellitus; TNF-b polymorphism; insulin resistance; glycemia; glucose intolerance},
   language = {eng},
   issn = {0338-1684},
   journal = {Diabetes & Metabolism},
   title = {Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report},
   volume = {28},
   year = {2002}
}

TY  - JOUR
ID  - 399632
AU  - Kaňková, Kateřina - Márová, Ivana - Jansen, Eugene HJM - Vašků, Anna - Jurajda, Michal - Vácha, Jiří
PY  - 2002
TI  - Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report
JF  - Diabetes & Metabolism
VL  - 28
IS  - 3
SP  - 231
EP  - 231
PB  - Editions Masson
SN  - 03381684
KW  - Type 2 diabetes mellitus
KW  - TNF-b polymorphism
KW  - insulin resistance
KW  - glycemia
KW  - glucose intolerance
N2  - Background: The study was designed to investigate the associations among polymorphisms TNF-b NcoI and TNF-a -308G/A, plasma TNF-a levels and metabolic and anthropometric parameters related to insulin sensitivity in a set of 113 Caucasian subjects undergoing oral glucose tolerance test (oGTT). Methods: Genotypes were detected by PCR; BMI, WHR, glycemia during oGTT, fasting immunoreactive insulin, fasting C-peptide, HbA1c, total cholesterol, triglycerides, HDL, LDL and plasma TNF-a levels were measured in each subject. Results: Type 2 diabetes was diagnosed in 10 subjects, impaired glucose tolerance (IGT) in 41, normal glucose tolerance (NGT) in 62. Significant differences among genotypes of the TNF-b NcoI were observed for FPG (P=0.0063), LDL (P=0.0179) and marginally for total cholesterol (P=0.0763) in NGT group. After the classification of NGT subjects into obese and non-obese according to BMI, associations of TNF-b NcoI with FPG, LDL and cholesterol were proved in non-obese subgroup only. TNF-a -308G/A polymorphism was not associated with any of the parameters studied. TNF-a levels did not revealed difference among NGT, IGT and DM groups or genotype-dependent differences. Conclusions: Our results indicate significant association of the TNF-b NcoI polymorphism with FPG, LDL and total cholesterol in normoglycemic non-obese Caucasian subjects. This polymorphism could be involved in genetic modulation of glucose and lipid homeostasis and regulation of insulin sensitivity already in healthy state. Disturbances of this regulation could be component of pathogenesis of type 2 diabetes mellitus.
ER  -

KAŇKOVÁ, Kateřina; Ivana MÁROVÁ; Eugene HJM JANSEN; Anna VAŠKŮ; Michal JURAJDA a Jiří VÁCHA. Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report. \textit{Diabetes \&{} Metabolism}. Francie: Editions Masson, 2002, roč.~28, č.~3, s.~231-237. ISSN~0338-1684.

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