Genotype association of C(-735)T polymorphism in matrix
metalloproteinase 2 gene with G(8002)A endothelin 1 gene with
plaque psoriasis

J 2002

Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis

VAŠKŮ, Vladimír; Anna VAŠKŮ; Svatava TSCHÖPLOVÁ; Lydie IZAKOVIČOVÁ HOLLÁ; Věra SEMRÁDOVÁ et al.

Základní údaje

Originální název

Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis

Autoři

VAŠKŮ, Vladimír; Anna VAŠKŮ; Svatava TSCHÖPLOVÁ; Lydie IZAKOVIČOVÁ HOLLÁ; Věra SEMRÁDOVÁ a Jiří VÁCHA

Vydání

Dermatology, Basel, Karger, 2002, 1018-8665

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.973

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/02:00006175

Organizační jednotka

Lékařská fakulta

UT WoS

000176566500002

Klíčová slova anglicky

MMP-2; Endothelin-1; Gene polymorphism; Plaque psoriasis

Štítky

Endothelin-1, Gene polymorphism, MMP-2, Plaque psoriasis

Změněno: 18. 6. 2009 09:58, prof. MUDr. Anna Vašků, CSc.

Anotace

V originále

Excessive angiogenesis is one of the characteristic features of psoriasis. To determine the possible genetic background of neo-angiogenesis in plaque psoriasis, frequent polymorphisms in matrix metalloproteinase 2 (MMP-2) and endothelin 1 (ET-1) genes were studied. A significant difference in genotype distribution of C(-735)T MMP-2 between psoriatic and control patients was found (pcorr=0.008). Two associated genotypes (CCGG and CTGG) of the two polymorphisms were significantly less frequent in psoriatic patients (pcorr=0.03 and pcorr=0.008, respectively). The results seem to reflect a different susceptibility of MMP-2 as well as of some associated MMP-2 and ET-1 genotypes to psoriasis.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

VAŠKŮ, Vladimír; Anna VAŠKŮ; Svatava TSCHÖPLOVÁ; Lydie IZAKOVIČOVÁ HOLLÁ; Věra SEMRÁDOVÁ a Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. Dermatology. Basel: Karger, 2002, roč. 204, č. 4, s. 262-265. ISSN 1018-8665.

@article{404296,
   author = {Vašků, Vladimír and Vašků, Anna and Tschöplová, Svatava and Izakovičová Hollá, Lydie and Semrádová, Věra and Vácha, Jiří},
   article_location = {Basel},
   article_number = {4},
   keywords = {MMP-2; Endothelin-1; Gene polymorphism; Plaque psoriasis},
   language = {eng},
   issn = {1018-8665},
   journal = {Dermatology},
   title = {Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis},
   volume = {204},
   year = {2002}
}

TY  - JOUR
ID  - 404296
AU  - Vašků, Vladimír - Vašků, Anna - Tschöplová, Svatava - Izakovičová Hollá, Lydie - Semrádová, Věra - Vácha, Jiří
PY  - 2002
TI  - Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis
JF  - Dermatology
VL  - 204
IS  - 4
SP  - 262
EP  - 262
PB  - Karger
SN  - 10188665
KW  - MMP-2
KW  - Endothelin-1
KW  - Gene polymorphism
KW  - Plaque psoriasis
N2  - Excessive angiogenesis is one of the characteristic features of psoriasis. To determine the possible genetic background of neo-angiogenesis in plaque psoriasis, frequent polymorphisms in matrix metalloproteinase 2 (MMP-2) and endothelin 1 (ET-1) genes were studied. A significant difference in genotype distribution of C(-735)T MMP-2 between psoriatic and control patients was found (pcorr=0.008). Two associated genotypes (CCGG and CTGG) of the two polymorphisms were significantly less frequent in psoriatic patients (pcorr=0.03 and pcorr=0.008, respectively). The results seem to reflect a different susceptibility of MMP-2 as well as of some associated MMP-2 and ET-1 genotypes to psoriasis.
ER  -

VAŠKŮ, Vladimír; Anna VAŠKŮ; Svatava TSCHÖPLOVÁ; Lydie IZAKOVIČOVÁ HOLLÁ; Věra SEMRÁDOVÁ a Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. \textit{Dermatology}. Basel: Karger, 2002, roč.~204, č.~4, s.~262-265. ISSN~1018-8665.

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