| VAŠKŮ, Vladimír, Anna VAŠKŮ, Svatava TSCHÖPLOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ a Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. Dermatology. Basel: Karger, 2002, roč. 204, č. 4, s. 262-265. ISSN 1018-8665. |
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@article{404296,
author = {Vašků, Vladimír and Vašků, Anna and Tschöplová, Svatava and Izakovičová Hollá, Lydie and Semrádová, Věra and Vácha, Jiří},
article_location = {Basel},
article_number = {4},
keywords = {MMP-2; Endothelin-1; Gene polymorphism; Plaque psoriasis},
language = {eng},
issn = {1018-8665},
journal = {Dermatology},
title = {Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis},
volume = {204},
year = {2002}
}
TY - JOUR
ID - 404296
AU - Vašků, Vladimír - Vašků, Anna - Tschöplová, Svatava - Izakovičová Hollá, Lydie - Semrádová, Věra - Vácha, Jiří
PY - 2002
TI - Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis
JF - Dermatology
VL - 204
IS - 4
SP - 262
EP - 262
PB - Karger
SN - 10188665
KW - MMP-2
KW - Endothelin-1
KW - Gene polymorphism
KW - Plaque psoriasis
N2 - Excessive angiogenesis is one of the characteristic features of psoriasis. To determine the possible genetic background of neo-angiogenesis in plaque psoriasis, frequent polymorphisms in matrix metalloproteinase 2 (MMP-2) and endothelin 1 (ET-1) genes were studied. A significant difference in genotype distribution of C(-735)T MMP-2 between psoriatic and control patients was found (pcorr=0.008). Two associated genotypes (CCGG and CTGG) of the two polymorphisms were significantly less frequent in psoriatic patients (pcorr=0.03 and pcorr=0.008, respectively). The results seem to reflect a different susceptibility of MMP-2 as well as of some associated MMP-2 and ET-1 genotypes to psoriasis.
ER -
VAŠKŮ, Vladimír, Anna VAŠKŮ, Svatava TSCHÖPLOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ a Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. \textit{Dermatology}. Basel: Karger, 2002, roč.~204, č.~4, s.~262-265. ISSN~1018-8665.
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